Results 1 to 10 of about 3,520 (91)

SALL4 expression in gonocytes and spermatogonial clones of postnatal mouse testes. [PDF]

PLoS ONE, 2013
The spermatogenic lineage is established after birth when gonocytes migrate to the basement membrane of seminiferous tubules and give rise to spermatogonial stem cells (SSC). In adults, SSCs reside within the population of undifferentiated spermatogonia (
Kathrin Gassei, Kyle E Orwig
doaj   +13 more sources

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia [PDF]

Nature Communications, 2019
Sustained sperm production is dependent on activity of undifferentiated spermatogonia. Here, the authors demonstrate an essential role for RNA helicase DDX5 in maintenance of spermatogonia in adults through control of gene transcription plus RNA ...
Julien M. D. Legrand, Ai-Leen Chan, Hue M. La, Fernando J. Rossello, Minna-Liisa Änkö, Frances V. Fuller-Pace, Robin M. Hobbs   +6 more
doaj   +4 more sources

Mitochondrial fusion is required for spermatogonial differentiation and meiosis [PDF]

eLife, 2019
Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Grigor Varuzhanyan, Rebecca Rojansky, Michael J Sweredoski, Robert LJ Graham, Sonja Hess, Mark S Ladinsky, David C Chan   +6 more
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The netrin-1 receptor UNC5C contributes to the homeostasis of undifferentiated spermatogonia in adult mice

Stem Cell Research, 2022
In adult testis, the cell mobility is essential for spermatogonia differentiation and is suspected to regulate spermatogonial stem cell fate. Netrin-1 controls cell migration and/or survival according to the cellular context. Its involvement in some self-
Vilma Barroca, Chrystele Racine, Laurent Pays, Pierre Fouchet, Mathieu Coureuil, Isabelle Allemand   +5 more
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BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate

Frontiers in Cell and Developmental Biology, 2023
Introduction: Spermatogenesis is sustained by the homeostasis of self-renewal and differentiation of undifferentiated spermatogonia throughout life, which is regulated by transcriptional and posttranscriptional mechanisms.
Ruiqi Liu, Yonglin Peng, Wenfei Du, Yunqiang Wu, Wen Zhang, Congxia Hu, Min Liu, Xinhua Liu, Ji Wu, Jielin Sun, Xiaodong Zhao   +10 more
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Core binding factor subunit β plays diverse and essential roles in the male germline

Frontiers in Cell and Developmental Biology, 2023
Much of the foundation for lifelong spermatogenesis is established prior to puberty, and disruptions during this developmental window negatively impact fertility long into adulthood.
Mustika Rahmawati, Mustika Rahmawati, Kassie M. Stadler, Blanca Lopez-Biladeau, Tia M. Hoisington, Tia M. Hoisington, Nathan C. Law, Nathan C. Law   +7 more
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Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. [PDF]

PLoS ONE, 2010
Vaccinia-related kinase 1 (VRK1) is a crucial protein kinase for mitotic regulation. VRK1 is known to play a role in germ cell development, and its deficiency results in sterility.
Yoon Ha Choi, Choon-Ho Park, Wanil Kim, Hua Ling, Aram Kang, Matthew Wook Chang, Sun-Kyoung Im, Hyun-Woo Jeong, Young-Yun Kong, Kyong-Tai Kim   +9 more
doaj   +1 more source

Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression

Cell & Bioscience, 2023
Background Spermatogonial stem cells (SSCs) provide a foundation for robust and continual spermatogenesis in mammals. SSCs self-renew to maintain a functional stem cell pool and differentiate to supply committed progenitors.
Rong-Ge Yan, Zhen He, Fei-Chen Wang, Shuang Li, Qin-Bang Shang, Qi-En Yang   +5 more
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Testicular Localization and Potential Function of Vimentin Positive Cells during Spermatogonial Differentiation Stages

Animals, 2022
Vimentin is a type of intermediate filament (IF) and one of the first filaments expressed in spermatogenesis. Vimentin plays numerous roles, consisting of the determination of cell shape, differentiation, cell motility, the maintenance of cell junctions,
Amirreza Niazi Tabar, Hossein Azizi, Danial Hashemi Karoii, Thomas Skutella   +3 more
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Culture of Kenyan Goat (Capra hircus) Undifferentiated Spermatogonia in Feeder-Free Conditions

Frontiers in Veterinary Science, 2022
The undifferentiated spermatogonial population in mammalian testes contains a spermatogonial stem cell (SSC) population that can regenerate continual spermatogenesis following transplantation.
Nakami Wilkister Nabulindo, Nakami Wilkister Nabulindo, James Nguhiu-Mwangi, Ambrose Ng'eno Kipyegon, Moses Ogugo, Charity Muteti, Tiambo Christian, Melissa J. Oatley, Jon M. Oatley, Stephen Kemp   +9 more
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