Results 11 to 20 of about 3,589 (156)

BRCA1 preserves genome integrity during the formation of undifferentiated spermatogonia

EMBO Reports
Undifferentiated spermatogonia, which form shortly after birth, consist of spermatogonial stem cells and progenitor spermatogonia that maintain homeostasis.
Peng Li, Licun Song, Longfei Ma, Chunsheng Han, Lejun Li, Lin-Yu Lu, Yidan Liu   +6 more
doaj   +3 more sources

A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche

Advanced Science
Childhood cancer treatments often impair male fertility due to gonadotoxic effects. While in vitro culture of prepubertal testis tissue offers a potential solution to preserve fertility, producing sufficient sperm remains a major barrier. To address this,
Yu Xia, Xiaoxuan Zhang, Bohang Zhang, Minhui Lu, Qing Cheng, Li Liu, Lifang Shi, Yiqiang Cui, Dingdong Chen, Laihua Li, Xuejiang Guo, Jingtao Guo, Jiahao Sha, Yuanjin Zhao, Yan Yuan   +14 more
doaj   +2 more sources

Persistence of undifferentiated spermatogonia in aged Japanese Black cattle [PDF]

Animal Science Journal, 2021
AbstractAging is a major risk factor for spermatogenesis deterioration. However, the influence of age on spermatogenic stem cells and their progenitors in bulls is largely unknown. Here, we report age‐related changes in undifferentiated and differentiating spermatogonia in Japanese Black cattle with nearly constant sperm output, by using spermatogonial
Terumichi Kawahara, Miki Kanouchi, Yousuke Naniwa, Masanori Koyago, Takashi Numabe, Keishi Mizutani, Kentaro Tanemura, Kenshiro Hara   +7 more
openaire   +2 more sources

Doxorubicin and vincristine affect undifferentiated rat spermatogonia [PDF]

Reproduction, 2017
Anticancer drugs, such as alkylating agents, can affect male fertility by targeting the DNA of proliferative spermatogonial stem cells (SSC). Therefore, to reduce such side effects, other chemotherapeutics are used. However, less is known about their potential genotoxicity on SSC. Moreover, DNA repair mechanisms in SSC are poorly understood.
Beaud, Hermance, van Pelt, Ans M., Delbès, Géraldine   +2 more
openaire   +4 more sources

Long-Term Propagation of Porcine Undifferentiated Spermatogonia [PDF]

Stem Cells and Development, 2017
Spermatogonial stem cells (SSCs) provide the foundation for spermatogenesis and fertility throughout the adult life of a male. Genetic manipulations of SSCs combined with germ cell transplantation present a novel approach for gene therapy and production of genetically modified animals.
Zhang, Pengfei, Chen, Xiaoxu, Zheng, Yi, Zhu, Jinshen, Qin, Yuwei, Lv, Yinghua, Zeng, Wenxian   +6 more
openaire   +3 more sources

The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse [PDF]

BMC Developmental Biology, 2009
AbstractBackgroundLife-long production of spermatozoa depends on spermatogonial stem cells. Spermatogonial stem cells exist among the most primitive population of germ cells – undifferentiated spermatogonia. Transplantation experiments have demonstrated the functional heterogeneity of undifferentiated spermatogonia.
Zheng, Ke, Wu, Xin, Kaestner, Klaus H, Wang, Peijing   +3 more
openaire   +2 more sources

Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch. [PDF]

, 2020
Male factor infertility is a problem in today's society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) knockout mouse line (SCCx43KO) has provided a translational model ...
Behr, Rüdiger, Brehm, Ralph HJ, Distl, Ottmar, Hilbold, Erika, Hoedemaker, Martina, Jung, Klaus, Langeheine, Marion, Metzger, Julia, Rajkovic, Aleksandar, Rode, Kristina, Wilkening, Sandra   +10 more
core   +1 more source

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation.

PLoS Genetics, 2021
Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases.
Jinyue Liao, Hoi Ching Suen, Alfred Chun Shui Luk, Lele Yang, Annie Wing Tung Lee, Huayu Qi, Tin-Lap Lee   +6 more
doaj   +1 more source

The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia [PDF]

Development, 2016
Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout adulthood through balanced self-renewal and differentiation, yet the regulatory logic of these fate decisions is poorly understood. The transcription factors Sal-like 4 (SALL4) and zinc finger and BTB domain containing 16 (ZBTB16, aka: PLZF) are known to be required for normal SSC ...
Dawn L. Lovelace, Zhen Gao, Kazadi Mutoji, Yuntao Charlie Song, Jianhua Ruan, Brian P. Hermann   +5 more
openaire   +2 more sources

DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

eLife, 2020
Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with ...
Maria M Mikedis, Yuting Fan, Peter K Nicholls, Tsutomu Endo, Emily K Jackson, Sarah A Cobb, Dirk G de Rooij, David C Page   +7 more
doaj   +1 more source