Results 31 to 40 of about 3,589 (156)

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Stem Cell Reports, 2017
Sustained spermatogenesis in adult males and fertility recovery following germ cell depletion are dependent on undifferentiated spermatogonia. We previously demonstrated a key role for the transcription factor SALL4 in spermatogonial differentiation ...
Ai-Leen Chan, Hue M. La, Julien M.D. Legrand, Juho-Antti Mäkelä, Michael Eichenlaub, Mia De Seram, Mirana Ramialison, Robin M. Hobbs   +7 more
doaj   +1 more source

The Transition from Stem Cell to Progenitor Spermatogonia and Male Fertility Requires the SHP2 Protein Tyrosine Phosphatase [PDF]

, 2014
SHP2 is a widely expressed protein tyrosine phosphatase required for signal transduction from multiple cell surface receptors. Gain and loss of function SHP2 mutations in humans are known to cause Noonan and LEOPARD syndromes, respectively, that are ...
Feng, Gen‐sheng, King, Philip D., Lapinski, Philip E., Orwig, Kyle E., Phillips, Bart T., Puri, Pawan, Rajkovic, Aleksandar, Suzuki, Hitomi, Walker, William H.   +8 more
core   +1 more source

Purification of GFRα1+ and GFRα1– Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination

Stem Cell Reports, 2018
Summary: Undifferentiated spermatogonia comprise a pool of stem cells and progenitor cells that show heterogeneous expression of markers, including the cell surface receptor GFRα1.
Alina Garbuzov, Matthew F. Pech, Kazuteru Hasegawa, Meena Sukhwani, Ruixuan J. Zhang, Kyle E. Orwig, Steven E. Artandi   +6 more
doaj   +1 more source

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

eLife, 2022
Alternative splicing expands the transcriptome and proteome complexity and plays essential roles in tissue development and human diseases. However, how alternative splicing regulates spermatogenesis remains largely unknown.
Wenbo Liu, Xukun Lu, Zheng-Hui Zhao, Ruibao SU, Qian-Nan Li Li, Yue Xue, Zheng Gao, Si-Min Sun Sun, Wen-Long Lei, Lei Li, Geng An, Hanyan Liu, Zhiming Han, Ying-Chun Ouyang, Yi Hou, Zhen-Bo Wang, Qing-Yuan Sun, Jianqiao Liu   +17 more
doaj   +1 more source

Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish Synbranchus marmoratus (Synbranchiformes: Synbranchidae) [PDF]

, 2018
Teleostei present great plasticity regarding sex change. During sex reversal, the whole gonadincluding the germinal epithelium undergoes significant changes, remodeling, and neoformation.However, there is no information on the changes that occur within ...
Antoneli, Fernanda, Lo Nostro, Fabiana Laura, Mazzoni, Talita Sarah, Quagio-Grassiotto, Irani   +3 more
core   +2 more sources

UTF1, a putative marker for spermatogonial stem cells in stallions. [PDF]

PLoS ONE, 2014
Spermatogonial stem cells (SSCs) continuously undergo self-renewal and differentiation to sustain spermatogenesis throughout adulthood in males. In stallions, SSCs may be used for the production of progeny from geldings after cryopreservation and therapy
Heejun Jung, Janet F Roser, Minjung Yoon
doaj   +1 more source

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche. [PDF]

, 2017
A major challenge in stem cell differentiation is the availability of bioassays to prove cell types generated in vitro are equivalent to cells in vivo. In the mouse, differentiation of primordial germ cell-like cells (PGCLCs) from pluripotent cells was ...
Chen, Di, Clark, Amander T, Hennebold, Jon D, Lam, Truong N, Meistrich, Marvin L, Mitchell, Jennifer M, Orwig, Kyle E, Peters, Karen A, Rojas, Ernesto J, Shetty, Gunapala, Sosa, Enrique, Sukhwani, Meena, Tailor, Ramesh C, Wu, Zhuang   +13 more
core   +2 more sources

Identification of dynamic undifferentiated cell states within the male germline

Nature Communications, 2018
Sustained spermatogenesis depends on stem cell activity which is contained within a population of undifferentiated spermatogonia. Here, the authors identify a new population of undifferentiated spermatogonia in adult testis that expresses the ...
Hue M. La, Juho-Antti Mäkelä, Ai-Leen Chan, Fernando J. Rossello, Christian M. Nefzger, Julien M. D. Legrand, Mia De Seram, Jose M. Polo, Robin M. Hobbs   +8 more
doaj   +1 more source

Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism [PDF]

, 2013
[Abstract] Lin28 (also termed Lin28a) and Lin28b are related RNA-binding proteins, involved in the control of microRNA synthesis, especially of the let-7 family, with putative functions in early (embryo) development. However, their roles during postnatal
Cordido, Fernando, García-Galiano, David, Gaytán, Francisco, León, Silvia, Manfredi-Lozano, María, Morales, Concepción, Pinilla, Leonor, Romero-Ruiz, Antonio, Ruiz-Pino, Francisco, Sangiao-Alvarellos, Susana, Tena-Sempere, Manuel   +10 more
core   +2 more sources

Conditions for Long-Term Culture of Cattle Undifferentiated Spermatogonia

Biology of Reproduction, 2016
Continual and robust spermatogenesis relies on the actions of an undifferentiated spermatogonial population that contains stem cells. A remarkable feature of spermatogonial stem cells (SSCs) is the capacity to regenerate spermatogenesis following isolation from a donor testis and transplantation into a permissive recipient testis.
Melissa J, Oatley, Amy V, Kaucher, Qi-En, Yang, Muhammad Salman, Waqas, Jon M, Oatley   +4 more
openaire   +2 more sources