Results 41 to 50 of about 3,589 (156)
The niche-derived glial cell line-derived neurotrophic factor (GDNF) induces migration of mouse spermatogonial stem/progenitor cells. [PDF]
PLoS ONE, 2013 In mammals, the biological activity of the stem/progenitor compartment sustains production of mature gametes through spermatogenesis. Spermatogonial stem cells and their progeny belong to the class of undifferentiated spermatogonia, a germ cell ...
Lisa Dovere +8 more
doaj +1 more source
SOHLH1 and SOHLH2 control Kit expression during postnatal male germ cell development [PDF]
, 2012 How Kit expression is regulated in the germline remains unknown. SOHLH1 and SOHLH2, two bHLH transcription factors specifically expressed in germ cells, are involved in spermatogonia and oocyte differentiation. In the male, deletion of each factor causes
Barrios, F +9 more
core +2 more sources
Beyond stem cells: Commitment of progenitor cells to meiosis
Stem Cell Research, 2018 The first step in established spermatogenesis is the production of progenitor cells by the stem cell population. The progenitor cells (undifferentiated A spermatogonia) expand in number via the formation of syncytial chains by mitosis.
Michael D. Griswold, Cathryn Hogarth
doaj +1 more source
Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population
Developmental Biology, 2008 Nanos gene encodes for zinc-finger protein with putative RNA-binding activity which shows an evolutionary conserved function in germ cell development. In the mouse, three Nanos homologs have been identified: Nanos1, Nanos2 and Nanos3. The Nanos3 ortholog is expressed in both male and female gonads of early embryo and, after birth, it is found only in ...
Lolicato, F +6 more
openaire +4 more sources
Differential Expression of c-kit in Mouse Undifferentiated and Differentiating Type A Spermatogonia [PDF]
Endocrinology, 1999 The proto-oncogene c-kit is encoded at the white-spotting locus and in the mouse mutations at this locus affect the precursor cells of melanocytes, hematopoietic cells, and germ cells. c-kit is expressed in type A spermatogonia, but whether or not c-kit is present both in undifferentiated and differentiating type A spermatogonia or only in the latter ...
Schrans-Stassen, B. H. +3 more
openaire +4 more sources
The essential roles of M ps 1 in spermatogenesis and fertility in mice
Cell Death and Disease, 2021 Monopolar spindle 1 (MPS1), which plays a critical role in somatic mitosis, has also been revealed to be essential for meiosis I in oocytes. Spermatogenesis is an important process involving successive mitosis and meiosis, but the function of MPS1 in ...
Qiang Fang +8 more
doaj +1 more source
Expression patterns of gdnf and gfrα1 in rainbow trout testis. [PDF]
, 2014 In mice, glial cell line-derived neurotrophic factor (GDNF) is essential for normal spermatogenesis and in vitro culture of spermatogonial stem cells. In murine testes, GDNF acts as paracrine factor; Setoli cells secrete it to a subset of spermatogonial ...
Kazuma Yamaguchi +5 more
core +2 more sources
Igf Binding Proteins Protect Undifferentiated Spermatogonia in the Zebrafish Testis Against Excessive Differentiation [PDF]
Endocrinology, 2016 IGF binding proteins (IGFBPs) modulate the availability of IGFs for their cognate receptors. In zebrafish testes, IGF3 promotes the proliferation and differentiation of type A undifferentiated (Aund) spermatogonia, and igf3 expression is strongly elevated by FSH but also responds to T3.
Safian Carrillo, Diego +3 more
openaire +4 more sources
Dynamic stem cell heterogeneity. [PDF]
, 2015 Recent lineage-tracing studies based on inducible genetic labelling have emphasized a crucial role for stochasticity in the maintenance and regeneration of cycling adult tissues.
Krieger, Teresa, Simons, Benjamin D
core +3 more sources
Cell Death and Disease, 2021 Spermatogonia transit-amplifying (TA) divisions are crucial for the differentiation of germline stem cell daughters. However, the underlying mechanism is largely unknown.
Jun Yu +9 more
doaj +1 more source