Recent Update on Retinoic Acid-Driven Initiation of Spermatogonial Differentiation
Frontiers in Cell and Developmental Biology, 2022 Germ cells (Gc) propagate the genetic information to subsequent generations. Diploid (2n) Gc get transformed to specialized haploid (n) gametes by mitotic and meiotic divisions in adult gonads.
Indrashis Bhattacharya +5 more
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ID4 levels dictate the stem cell state in mouse spermatogonia [PDF]
, 2017 Spermatogenesis is a classic model of cycling cell lineages that depend on a balance between stem cell self-renewal for continuity and the formation of progenitors as the initial step in the production of differentiated cells.
Helsel, Aileen R. +5 more
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Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
Nature Communications, 2021 Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene ...
Xiaoyu Zhang +2 more
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Cell Proliferation, 1985 AbstractIn the seminiferous epithelium the differentiating spermatogonia proliferate following a very strict synchronous pattern, and undergo the S phase during parts of particular epithelial stages. the undifferentiated spermatogonia do not divide synchronously and display maximum proliferative activity in stages XI‐III.
de rooij, D. G., Lok, D., Weenk, D.
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Spermatogonial stem cell niche and spermatogonial stem cell transplantation in zebrafish. [PDF]
PLoS ONE, 2010 BACKGROUND: Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and reside within a specific microenvironment in the testes called "niche" which regulates stem cell properties, such as, self-renewal, pluripotency, quiescence and their
Rafael Henrique Nóbrega +5 more
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Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis [PDF]
, 2015 Spermatogenesis is a highly regulated process that involves both mitotic and meiotic divisions, as well as cellular differentiation to yield mature spermatozoa from undifferentiated germinal stem cells.
Cattaneo, Elizabeth Renee +6 more
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Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms [PDF]
, 2017 Sex cord-stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2–5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between ...
Cheng, Liang +2 more
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Wt1 deficiency causes undifferentiated spermatogonia accumulation and meiotic progression disruption in neonatal mice [PDF]
REPRODUCTION, 2014 Spermatogenesis is a complex process involving the regulation of multiple cell types. As the only somatic cell type in the seminiferous tubules, Sertoli cells are essential for spermatogenesis throughout the spermatogenic cycle. The Wilms tumor gene,Wt1, is specifically expressed in the Sertoli cells of the mouse testes.
Qiao-Song, Zheng +10 more
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Andrology, 2023 AbstractBackgroundAcetaminophen and ibuprofen are widely administered to babies due to their presumed safety as over‐the‐counter drugs. However, no reports exist on the effects of cyclooxygenase inhibitors on undifferentiated spermatogonia and spermatogonial stem cells.
Amy Tran‐Guzman +2 more
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Developmental changes in the histological structure of the testes, and testosterone profiles in male guinea fowls (Numida meleagris) [PDF]
, 2017 Owing to the paucity of information on the reproductive biology of guinea fowls, a study involving a total of 66 males was conducted, and documented the developmental changes in histological structure of the testes of guinea cocks from hatching until ...
Abdul-Rahman, Iddriss I. +2 more
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