The Unfolded Protein Response: An Overview [PDF]
Biology, 2021 The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
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Unfolded protein response in colorectal cancer [PDF]
Cell & Bioscience, 2021 Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal ...
Jingjing Huang +8 more
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The unfolded protein response in immunity and inflammation [PDF]
Nature Reviews Immunology, 2016 The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands associated with environmental forces.
J. Grootjans +3 more
semanticscholar +6 more sources
Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response [PDF]
, 2004 Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus.
Christopher K. Patil +2 more
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A stress paradox: the dual role of the unfolded protein response in the placenta [PDF]
Frontiers in EndocrinologyThe placenta is a temporary organ that forms during pregnancy and is essential for fetal development and maternal health. As an endocrine organ, proper placental function requires continual production, folding, and transport of proteins and lipids ...
Diba Chowdhury +7 more
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Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation [PDF]
Cell, 2000 Kevin Travers +5 more
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Navigating the landscape of the unfolded protein response in CD8+ T cells [PDF]
Frontiers in ImmunologyEndoplasmic reticulum stress occurs due to large amounts of misfolded proteins, hypoxia, nutrient deprivation, and more. The unfolded protein is a complex intracellular signaling network designed to operate under this stress. Composed of three individual
Keith Alan Nair +3 more
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A statistical mechanics investigation of unfolded protein response across organisms [PDF]
Scientific ReportsLiving systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a critical ...
Nicole Luchetti +5 more
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Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response [PDF]
Molecules and Cells, 2000 Heather P. Harding +4 more
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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response [PDF]
Molecular and Cellular Biology, 2003 Ann–Hwee Lee +2 more
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