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Frontiers in Molecular Neuroscience, 2022 Aging and age-related neurodegeneration are both associated with the accumulation of unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis (termed proteostasis) in maintaining organismal health.
Andrew P. K. Wodrich +7 more
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The Unfolded Protein Response: An Overview
Biology, 2021 The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
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The unfolded protein response protects from tau neurotoxicity in vivo. [PDF]
PLoS ONE, 2010 The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention.
Carin A Loewen, Mel B Feany
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Indonesian Journal of Biotechnology, 2021 Plants activate the unfolded protein response as part of cellular adaptation, thereby maintaining the endoplasmic reticulum homeostasis during external stresses exposure.
Galang Rizki Ramadhan +3 more
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Unfolded protein response in colorectal cancer
Cell & Bioscience, 2021 Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal ...
Jingjing Huang +8 more
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Unfolded protein response in myelin disorders
Neural Regeneration Research, 2020 Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions.
Wensheng Lin, Sarrabeth Stone
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Unfolded protein response in the COVID-19 context
Aging and Health Research, 2021 The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability.
Nektarios Barabutis
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Unfolded Protein Corona Surrounding Nanotubes Influence the Innate and Adaptive Immune System
Advanced Science, 2021 The plasma proteins around nanoparticles (NPs) form an outer protein corona, significantly influencing the subsequent immune response. However, it was uncertain whether the protein corona around NPs influences immune response.
Jun‐Young Park +6 more
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The unfolded protein response has a protective role in yeast models of classic galactosemia
Disease Models & Mechanisms, 2014 Classic galactosemia is a human autosomal recessive disorder caused by mutations in the GALT gene (GAL7 in yeast), which encodes the enzyme galactose-1-phosphate uridyltransferase.
Evandro A. De-Souza +6 more
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StresSeed: The Unfolded Protein Response During Seed Development
Frontiers in Plant Science, 2022 During seed development, the endoplasmic reticulum (ER) takes care of the synthesis and structural maturation of very high amounts of storage proteins in a relatively short time.
Alessandro Vitale, Emanuela Pedrazzini
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