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The Unfolded Protein Response: An Overview [PDF]
Biology, 2021 The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
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Unfolded protein response in colorectal cancer [PDF]
Cell & Bioscience, 2021 Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal ...
Jingjing Huang +8 more
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Unfolded protein response in myelin disorders
Neural Regeneration Research, 2020 Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions.
Wensheng Lin, Sarrabeth Stone
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Frontiers in Molecular Neuroscience, 2022 Aging and age-related neurodegeneration are both associated with the accumulation of unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis (termed proteostasis) in maintaining organismal health.
Andrew P. K. Wodrich +7 more
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Unfolded protein response [PDF]
Current Biology, 2012 SummaryIn eukaryotic cells, the endoplasmic reticulum (ER) is a membrane-enclosed interconnected organelle responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins. The processes of protein folding and maturation are highly assisted and scrutinized but are also sensitive to changes in ER ...
Cao, Stewart Siyan, Kaufman, Randal J.
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The unfolded protein response [PDF]
Journal of Cell Science, 2003 The endoplasmic reticulum (ER) is a principal site for folding and maturation of transmembrane, secretory and ER-resident proteins. Perturbations that alter ER homeostasis can lead to accumulation of unfolded proteins (UPs), which is a threat to all living cells.
Chuan Yin, Liu, Randal J, Kaufman
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The unfolded protein response protects from tau neurotoxicity in vivo. [PDF]
PLoS ONE, 2010 The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention.
Carin A Loewen, Mel B Feany
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The unfolded protein response [PDF]
Current Biology, 2005 Where does the UPR function? Between the endoplasmic reticulum (ER) and the nucleus of eukaryotic cells. All secreted proteins and proteins that reside in secretory compartments translocate as nascent peptide chains into the ER, where they may undergo folding, modification and assembly before assuming their functional conformations.
Chawla, Aditi, Niwa, Maho
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Indonesian Journal of Biotechnology, 2021 Plants activate the unfolded protein response as part of cellular adaptation, thereby maintaining the endoplasmic reticulum homeostasis during external stresses exposure.
Galang Rizki Ramadhan +3 more
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Unfolded protein response in the COVID-19 context
Aging and Health Research, 2021 The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability.
Nektarios Barabutis
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