Study of global transcriptional changes of N-GlcNAc2 proteins-producing T24 bladder carcinoma cells under glucose deprivation. [PDF]
PLoS ONE, 2013 Increased levels of N-linked (β-N- acetylglucosamine)2 [N-GlcNAc2]-modified proteins have been recognized to be an effective response to glucose deprivation.
Takahiro Isono +3 more
doaj +1 more source
ROS and Endoplasmic Reticulum Stress in Pulmonary Disease
Frontiers in Pharmacology, 2022 Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies show that though specific pulmonary diseases and correlative lung-metabolic deviance own unique pathophysiology and clinical manifestations, they always tend to ...
Xiangning Cui +3 more
doaj +1 more source
Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]
, 2015 The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia +2 more
core +1 more source
BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana [PDF]
, 2019 The unfolded protein response (UPR) is required for protein homeostasis in the endoplasmic reticulum (ER) when plants are challenged by adverse environmental conditions.
Hong, Zheng-Hui +4 more
core +1 more source
Unfolded protein response in cancer: the Physician's perspective
Journal of Hematology & Oncology, 2011 The unfolded protein response (UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer cells are often exposed to hypoxia, nutrient
Li Zihai, Zhang Kezhong, Li Xuemei
doaj +1 more source
Surviving the heat of the moment : a fungal pathogens perspective [PDF]
, 2013 Peer reviewedPublisher ...
Cowen, Leah E, Leach, Michelle D
core +2 more sources
Yap Regulates ATF6-Mediated Unfolded Protein Response [PDF]
, 2015 Hippo信号通路最早在果蝇里发现，是在进化上高度保守的一条激酶级联的通路，当Hippo通路的缺失会造其下游调控因子Yap或Taz的激活，促进细胞增殖，抑制细胞凋亡，从而导致器官增大和肿瘤产生。此外，大量文献阐述了内质网压力和肿瘤产生具有相关性。本实验室研究表明，Hippo通路的缺失或Yap蛋白的激活会引起内质网应激信号通路的激活和内质网的增大，并通过内质网应激反应导致肝脏器官增大和肿瘤生成。 当Hippo激酶，在高等动物的同源物为Mst1和Mst2激酶的缺失或Yap激活时 ...
蔡亚波
core
Stroke, 2020 Supplemental Digital Content is available in the text. Background and Purpose— Ischemic stroke impairs endoplasmic reticulum (ER) function, causes ER stress, and activates the unfolded protein response.
Ya-chao Wang +6 more
semanticscholar +1 more source
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death [PDF]
, 2019 STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in ...
Chen, Yu-Ju +6 more
core +1 more source
MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?
EMBO Molecular Medicine, 2020 The transcription factors of the MYC family play pivotal roles in the initiation and progression of human cancers. High oncogenic level of MYC invades low‐affinity sites and enhancer sequences, which subsequently alters the transcriptome, causes ...
Tingting Zhang +4 more
semanticscholar +1 more source