The Unfolded Protein Response: An Overview [PDF]
Biology, 2021 The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
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Unfolded protein response in colorectal cancer [PDF]
Cell & Bioscience, 2021 Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal ...
Jingjing Huang +8 more
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Unfolded protein response in myelin disorders
Neural Regeneration Research, 2020 Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions.
Wensheng Lin, Sarrabeth Stone
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Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response [PDF]
, 2004 Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus.
Christopher K. Patil +2 more
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The unfolded protein response in multiple sclerosis [PDF]
Frontiers in Neuroscience, 2015 The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER.
Wensheng eLin, Sarrabeth eStone
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New twists in the unfolded protein response
eLife, 2012 The response of S. pombe, also known as fission yeast, to misfolded proteins involves mechanisms that have not been observed in other species.
Benedict C S Cross, David Ron
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A stress paradox: the dual role of the unfolded protein response in the placenta [PDF]
Frontiers in EndocrinologyThe placenta is a temporary organ that forms during pregnancy and is essential for fetal development and maternal health. As an endocrine organ, proper placental function requires continual production, folding, and transport of proteins and lipids ...
Diba Chowdhury +7 more
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Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation [PDF]
Cell, 2000 Kevin Travers +5 more
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Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response [PDF]
Molecules and Cells, 2000 Heather P. Harding +4 more
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Mechanisms, regulation and functions of the unfolded protein response
Nature Reviews Molecular Cell Biology, 2020 , Kezhong Zhang, Randal J Kaufman
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