Results 31 to 40 of about 167,289 (308)

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure [PDF]

, 2015
Hepatocellular carcinoma (HCC) is characterized by the accumulation of unfolded proteins in the endoplasmic reticulum (ER), which activates the unfolded protein response (UPR).
Ampe, Christophe, Bogaerts, Eliene, Descamps, Benedicte, Devisscher, Lindsey, Geerts, Anja, Govaere, O, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van den Bussche, A, Van Steenkiste, Christophe, Van Troys, Marleen, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vanhove, Christian, Verhelst, Xavier   +16 more
core   +3 more sources

Stress Management: How the Endoplasmic Reticulum Mitigates Protein Misfolding and Oxidative Stress by the Dual Role of Glutathione Peroxidase 8

Biomolecules
The endoplasmic reticulum mediates essential processes such as protein folding, transport, and post-translational modifications. Disruptions in endoplasmic reticulum function can lead to the accumulation of unfolded or misfolded proteins, initiating ...
Yong Yang, Hao Peng, Danni Meng, Zizhu Fa, Chen Yao, Xinyu Lin, Joel Schick, Xiang Jin   +7 more
doaj   +1 more source

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08)

Haematologica, 2016
Downregulation of the unfolded protein response mediates proteasome inhibitor resistance in multiple myeloma. The Human Immunodeficieny Virus protease inhibitor nelfinavir activates the unfolded protein response in vitro.
Christoph Driessen, Marianne Kraus, Markus Joerger, Hilde Rosing, Jürgen Bader, Felicitas Hitz, Catherine Berset, Alexandros Xyrafas, Hanne Hawle, Gregoire Berthod, Hermann S. Overkleeft, Christiana Sessa, Alwin Huitema, Thomas Pabst, Roger von Moos, Dagmar Hess, Ulrich J.M. Mey   +16 more
doaj   +1 more source

Identification of a novel signature based on unfolded protein response-related gene for predicting prognosis in bladder cancer

Human Genomics, 2021
Highlights 1. We first comprehensive investigated the expression, protein–protein interaction, and prognostic value of unfolded protein response-related gene in bladder cancer. 2.
Ke Zhu, Liu Xiaoqiang, Wen Deng, Gongxian Wang, Bin Fu   +4 more
doaj   +1 more source

Unfolded protein response is activated in Lewy body dementias [PDF]

, 2018
K
Aarsland, Dag, Attems, Johannes, Baek, Jean-Ha, Ballard, Clive G., Bereczki, Erika, Francis, Paul T., Hortobágyi, Tibor, Howlett, David R., Whitfield, David   +8 more
core   +1 more source

The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease

Bone Research
The unfolded protein response pathway is an evolutionarily conserved cytoprotective signaling cascade, essential for cell function and survival. Unfolded protein response signaling is tightly integrated with bone cell differentiation and function, and ...
Molly E. Muehlebach, Sarah A. Holstein
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Yeast Bax Inhibitor, Bxi1p, Is an ER-Localized Protein that Links the Unfolded Protein Response and Programmed Cell Death in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]

, 2011
Bax inhibitor-1 (BI-1) is an anti-apoptotic gene whose expression is upregulated in a wide range of human cancers. Studies in both mammalian and plant cells suggest that the BI-1 protein resides in the endoplasmic reticulum and is involved in the ...
Austriaco, Nicanor, Cascio, Vincent, Cebulski, James, Malouin, Joshua, Pinches, Nathan   +4 more
core   +1 more source

The Unfolded Protein Response in Amelogenesis and Enamel Pathologies [PDF]

, 2017
During the secretory phase of their life-cycle, ameloblasts are highly specialized secretory cells whose role is to elaborate an extracellular matrix that ultimately confers both form and function to dental enamel, the most highly mineralized of all ...
Barron, Bartlett, Basseri, Brookes, Brookes, Brookes, Brookes, Chen, Chlubek, Coelho, Credle, Den Besten, Denny, Dey, DiGiuseppe, Dobson, Eletto, Fava, Fribley, Galvan, Gardner, Gonzales, Gregersen, Han, Harding, Hassunuma, Hetz, Hetz, Hetz, Hollien, Hu, Inkielewicz-Stepniak, Iwasaki, Joseph, Joseph, Joseph, Kim, Kimata, Kopito, Kubota, Lacruz, Lakshminarayanan, Lee, Li, Li, Lin, Malhotra, Malhotra, Matsuo, Melchior, Moore, Moore, Moradian-Oldak, Moukdar, Nishio, Nomura, Novosyadlyy, Oakes, Ow, Ozcan, Paine, Prischi, Puthalakath, Reith, Ron, Rutkowski, Ryu, Santos, Schonthal, Schroder, Schubert, Selkoe, Sharma, Sharma, Sire, Smith, Smith, Smith, Smith, Su, Suzuki, Suzuki, Tabas, Tanabe, Teske, Tsuchiya, Tsuru, Tye, Upton, Valastyan, Vilatoba, Wang, Wei, Wu, Yam, Yoshida, Yue, Zhu, Zode   +98 more
core   +2 more sources

Unfolded Protein Response in Lung Health and Disease

Frontiers in Medicine, 2020
The unfolded protein response (UPR) is a complex element, destined to protect the cells against a diverse variety of extracellular and intracellular challenges. UPR activation devises highly efficient responses to counteract cellular threats.
Nektarios Barabutis
doaj   +1 more source