Results 31 to 40 of about 1,004,483 (288)
Indonesian Journal of Biotechnology, 2021 Plants activate the unfolded protein response as part of cellular adaptation, thereby maintaining the endoplasmic reticulum homeostasis during external stresses exposure.
Galang Rizki Ramadhan +3 more
doaj +1 more source
ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review
Biomolecules, 2023 Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein response (UPR), are triggered by the accumulation of unfolded and misfolded proteins. During osteoclastogenesis, a large number of active proteins are synthesized. When an
Wan-fang Huang, Yining Gong, Liang Yan
semanticscholar +1 more source
IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. [PDF]
, 2013 We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress.
Lane, Timothy F +6 more
core +9 more sources
The unfolded protein response [PDF]
Journal of Cell Science, 2003 The endoplasmic reticulum (ER) is a principal site for folding and maturation of transmembrane, secretory and ER-resident proteins. Perturbations that alter ER homeostasis can lead to accumulation of unfolded proteins (UPs), which is a threat to all living cells.
Randal J. Kaufman, Chuan Yin Liu
openaire +3 more sources
IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]
, 2020 IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear +54 more
core +1 more source
Journal of Hematology & Oncology, 2022 Mitochondria are essential for tumor growth and progression. However, the heavy demand for mitochondrial activity in cancer leads to increased production of mitochondrial reactive oxygen species (mtROS), accumulation of mutations in mitochondrial DNA ...
J. Inigo, D. Chandra
semanticscholar +1 more source
Herpesviruses and the Unfolded Protein Response [PDF]
Viruses, 2019 Herpesviruses usurp cellular stress responses to promote viral replication and avoid immune surveillance. The unfolded protein response (UPR) is a conserved stress response that is activated when the protein load in the ER exceeds folding capacity and misfolded proteins accumulate.
Benjamin P. Johnston +2 more
openaire +4 more sources
Cellular Response to Unfolded Proteins in Depression [PDF]
Life, 2021 Despite many scientific studies on depression, there is no clear conception explaining the causes and mechanisms of depression development. Research conducted in recent years has shown that there is a strong relationship between depression and the endoplasmic reticulum (ER) stress.
Mateusz Kowalczyk +5 more
openaire +3 more sources
Unfolded protein response in the COVID-19 context
Aging and Health Research, 2021 The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability.
Nektarios Barabutis
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of blood flow in a certain part of the brain, leading to serious disability and death.
Lei Wang +8 more
semanticscholar +1 more source