Results 51 to 60 of about 167,289 (308)
eLife, 2016 Two mechanisms ensure that the mRNA encoding Hac1 protein, a transcription factor involved in the unfolded protein response, is only translated when it is needed.
David J Young, Nicholas R Guydosh
doaj +1 more source
FEBS Open Bio, EarlyView.This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili +2 more
wiley +1 more source
Study of global transcriptional changes of N-GlcNAc2 proteins-producing T24 bladder carcinoma cells under glucose deprivation. [PDF]
PLoS ONE, 2013 Increased levels of N-linked (β-N- acetylglucosamine)2 [N-GlcNAc2]-modified proteins have been recognized to be an effective response to glucose deprivation.
Takahiro Isono +3 more
doaj +1 more source
ROS and Endoplasmic Reticulum Stress in Pulmonary Disease
Frontiers in Pharmacology, 2022 Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies show that though specific pulmonary diseases and correlative lung-metabolic deviance own unique pathophysiology and clinical manifestations, they always tend to ...
Xiangning Cui +3 more
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FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]
, 2015 The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia +2 more
core +1 more source
How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]
, 2017 Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias +2 more
core +2 more sources
Unfolded protein response in hepatitis C virus infection
Frontiers in Microbiology, 2014 Hepatitis C virus (HCV) is a single-stranded, positive-sense RNA virus of clinical importance. The virus establishes a chronic infection and can progress from chronic hepatitis, steatosis to fibrosis, cirrhosis and hepatocellular carcinoma.
Shiu-Wan eChan
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β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
Yap Regulates ATF6-Mediated Unfolded Protein Response [PDF]
, 2015 Hippo信号通路最早在果蝇里发现，是在进化上高度保守的一条激酶级联的通路，当Hippo通路的缺失会造其下游调控因子Yap或Taz的激活，促进细胞增殖，抑制细胞凋亡，从而导致器官增大和肿瘤产生。此外，大量文献阐述了内质网压力和肿瘤产生具有相关性。本实验室研究表明，Hippo通路的缺失或Yap蛋白的激活会引起内质网应激信号通路的激活和内质网的增大，并通过内质网应激反应导致肝脏器官增大和肿瘤生成。 当Hippo激酶，在高等动物的同源物为Mst1和Mst2激酶的缺失或Yap激活时 ...
蔡亚波
core