Results 51 to 60 of about 989,519 (369)
Proteostasis control by the unfolded protein response [PDF]
Nature Cell Biology, 2015 Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is observed in many physiological and pathological conditions. To cope with endoplasmic reticulum stress, cells activate the unfolded protein response, a dynamic signalling network that orchestrates the recovery of homeostasis or triggers apoptosis, depending on the level
C. Hetz, É. Chevet, Scott A Oakes
semanticscholar +7 more sources
The Unfolded Protein Response in Breast Cancer [PDF]
Cancers, 2018 In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new approaches are urgently required.
Katarzyna Mnich +11 more
openaire +4 more sources
Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response
Glomerular Diseases, 2022 Background: Fibrillary glomerulonephritis (FGN) is found in approximately 1% of native kidney biopsies and was traditionally defined by glomerular deposition of fibrils larger than amyloid (12–24 nm diameter) composed of polyclonal IgG.
Nicole K. Andeen +5 more
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Alzheimer's disease pathology and the unfolded protein response : Prospective pathways and therapeutic targets [PDF]
, 2017 The authors would like to thank Alzheimer's Research UK (Grant refs: ARUK-PPG2014A-21 and ARUK-NSG2015-1 to BP and DK) who have provided support for relevant projects leading to this review.Peer ...
Koss, David J, Platt, Bettina
core +1 more source
Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia
Cellular & Molecular Biology Letters, 2020 During hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR).
Sylwia Bartoszewska, J. Collawn
semanticscholar +1 more source
Membrane biogenesis and the unfolded protein response [PDF]
The Journal of Cell Biology, 2004 In addition to serving as the entry point for newly translated polypeptides making their way through the secretory pathway, the endoplasmic reticulum (ER) also synthesizes many lipid components of the entire endomembrane system. A report published in this issue implicates a signaling pathway known to respond to ER unfolded protein load in the control ...
David Ron, Randolph Y. Hampton
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Frontiers in Molecular Biosciences, 2019 The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its folding capacity.
Christopher J. Adams +4 more
semanticscholar +1 more source
Unfolded Protein Response in Lung Health and Disease
Frontiers in Medicine, 2020 The unfolded protein response (UPR) is a complex element, destined to protect the cells against a diverse variety of extracellular and intracellular challenges. UPR activation devises highly efficient responses to counteract cellular threats.
Nektarios Barabutis
doaj +1 more source
The Unfolded Protein Response at the Tumor-Immune Interface
Frontiers in Immunology, 2022 The tumor-immune interface has surged to primary relevance in an effort to understand the hurdles facing immune surveillance and cancer immunotherapy.
Maurizio Zanetti +3 more
doaj +1 more source
Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP. [PDF]
, 2019 Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bacteria and viruses, and in many cases this disruption of cellular function activates pathways of the unfolded protein response (UPR).
Atluri, Vidya L +14 more
core +1 more source