Results 51 to 60 of about 1,004,483 (288)
Dicarbonyl stress, protein glycation and the unfolded protein response
Glycoconjugate Journal, 2021 The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes.
N. Rabbani, M. Xue, Paul J Thornalley
semanticscholar +1 more source
Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? [PDF]
, 2015 Mitochondrial unfolded protein response is a form of retrograde signaling that contributes to ensuring the maintenance of quality control of mitochondria, allowing functional integrity of the mitochondrial proteome. When misfolded proteins or unassembled
Arnould, T., Michel, S., Renard, P.
core +3 more sources
Unfolded Protein Responses With or Without Unfolded Proteins? [PDF]
Cells, 2012 The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins. Mutant proteins and environmental stresses can overwhelm the available QC machinery.
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Untangling the unfolded protein response [PDF]
Cell Cycle, 2008 Resistance to current cancer therapies has forced scientists to investigate new avenues of therapy distinct from those aimed at single targets, to strategies based on targeting families of proteins, on which cancers rely for their ability to survive stress.
Faith E. Davies +2 more
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Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases
International Journal of Molecular Sciences, 2020 The endoplasmic reticulum (ER) is an important organelle involved in protein quality control and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress, followed by an adaptive response via the activation of the unfolded ...
Rose Ghemrawi, Mostafa Khair
semanticscholar +1 more source
Unfolded Protein Response in Arabidopsis [PDF]
, 2017 The unfolded protein response (UPR) is a highly regulated signaling pathway that is largely conserved across eukaryotes. It is essential for cell homeostasis under environmental and physiological conditions that perturb the protein folding in the endoplasmic reticulum (ER).
Cristina Ruberti, Federica Brandizzi
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Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. [PDF]
, 2013 Miner1 is a redox-active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan.
Andreyev, Alexander Y +12 more
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StresSeed: The Unfolded Protein Response During Seed Development
Frontiers in Plant Science, 2022 During seed development, the endoplasmic reticulum (ER) takes care of the synthesis and structural maturation of very high amounts of storage proteins in a relatively short time.
Alessandro Vitale, Emanuela Pedrazzini
doaj +1 more source
eLife, 2015 Eukaryotic cells possess a variety of signaling pathways that prevent accumulation of unfolded and misfolded proteins. Chief among these is the heat shock response (HSR), which is assumed to respond to unfolded proteins in the cytosol and nucleus alike ...
Yusuke Miyazaki +4 more
doaj +1 more source
Haematologica, 2012 Background Multiple myeloma, a malignancy of the antibody-secreting plasma cells, remains incurable by current therapy. However, the proteasome inhibitor bortezomib and other new drugs are revolutionizing its treatment.
Silvia C. W. Ling +11 more
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