Results 61 to 70 of about 989,519 (369)

Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases

Molecules, 2015
Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key
Irina Milisav, Dušan Šuput, Samo Ribarič   +2 more
doaj   +1 more source

A crosstalk between p21 and UPR-induced transcription factor C/EBP homologous protein (chop) linked to type 2 diabetes [PDF]

, 2013
Type 2 diabetes (T2D) is a disease that is characterized by raised levels of glucose in the blood combined with insulin resistance and relative insulin deficiency.
Kiaris, Hippokratis, Mihailidou, Chrysovalantou, Papavassiliou, Athanasios G.   +2 more
core   +1 more source

Stress Management: How the Endoplasmic Reticulum Mitigates Protein Misfolding and Oxidative Stress by the Dual Role of Glutathione Peroxidase 8

Biomolecules
The endoplasmic reticulum mediates essential processes such as protein folding, transport, and post-translational modifications. Disruptions in endoplasmic reticulum function can lead to the accumulation of unfolded or misfolded proteins, initiating ...
Yong Yang, Hao Peng, Danni Meng, Zizhu Fa, Chen Yao, Xinyu Lin, Joel Schick, Xiang Jin   +7 more
doaj   +1 more source

Identification of a novel signature based on unfolded protein response-related gene for predicting prognosis in bladder cancer

Human Genomics, 2021
Highlights 1. We first comprehensive investigated the expression, protein–protein interaction, and prognostic value of unfolded protein response-related gene in bladder cancer. 2.
Ke Zhu, Liu Xiaoqiang, Wen Deng, Gongxian Wang, Bin Fu   +4 more
doaj   +1 more source

The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB

Autophagy, 2020
Defective macroautophagy/autophagy and a failure to initiate the adaptive unfolded protein response (UPR) in response to the endoplasmic reticulum (ER) stress contributes to obesity-associated metabolic dysfunction. However, whether and how unresolved ER
Zeyuan Zhang, Q. Qian, Mark Li, Fan Shao, W. Ding, V. Lira, Sophia X Chen, S. Sebag, G. Hotamışlıgil, Huojun Cao, Ling Yang   +10 more
semanticscholar   +1 more source

The Unfolded Protein Response and its potential role in Huntington's disease [PDF]

, 2012
Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Kamesh Ayasolla, Matthias E. Futschik, Ravi K. R. Kalathur   +2 more
core   +2 more sources

When is the unfolded protein response not the unfolded protein response?

Plant Science, 2017
As sessile organisms, plants are subjected to variety of stresses for which they have evolved different protection mechanisms. One mechanism involves endoplasmic reticulum (ER) stress in which the process of protein folding is disturbed and misfolded proteins accumulate in the ER. ER stress elicits the unfolded protein response (UPR) whereby the stress
openaire   +3 more sources

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08)

Haematologica, 2016
Downregulation of the unfolded protein response mediates proteasome inhibitor resistance in multiple myeloma. The Human Immunodeficieny Virus protease inhibitor nelfinavir activates the unfolded protein response in vitro.
Christoph Driessen, Marianne Kraus, Markus Joerger, Hilde Rosing, Jürgen Bader, Felicitas Hitz, Catherine Berset, Alexandros Xyrafas, Hanne Hawle, Gregoire Berthod, Hermann S. Overkleeft, Christiana Sessa, Alwin Huitema, Thomas Pabst, Roger von Moos, Dagmar Hess, Ulrich J.M. Mey   +16 more
doaj   +1 more source

Unfolded protein response in the COVID-19 context

Aging and Health Research, 2021
The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability.
Nektarios Barabutis
doaj  

The Transcription Factor bZIP60 Links the Unfolded Protein Response to the Heat Stress Response in Maize[OPEN]

The Plant Cell, 2020
The transcription factor bZIP60 links a system that alerts plants to problems in protein folding to a system that protects plants from heat stress. The unfolded protein response (UPR) and the heat shock response (HSR) are two evolutionarily conserved ...
Zhaoxia Li, Jie Tang, R. Srivastava, D. Bassham, S. Howell   +4 more
semanticscholar   +1 more source