Results 61 to 70 of about 1,004,483 (288)
The Unfolded Protein Response in Breast Cancer [PDF]
Cancers, 2018 In 2018, in the US alone, it is estimated that 268,670 people will be diagnosed with breast cancer, and that 41,400 will die from it. Since breast cancers often become resistant to therapies, and certain breast cancers lack therapeutic targets, new approaches are urgently required.
Katarzyna Mnich +11 more
openaire +4 more sources
Proteostasis control by the unfolded protein response [PDF]
Nature Cell Biology, 2015 Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is observed in many physiological and pathological conditions. To cope with endoplasmic reticulum stress, cells activate the unfolded protein response, a dynamic signalling network that orchestrates the recovery of homeostasis or triggers apoptosis, depending on the level
C. Hetz, É. Chevet, Scott A Oakes
semanticscholar +7 more sources
Tidy up - The unfolded protein response in sepsis
Frontiers in Immunology, 2022 Pathogens, their toxic byproducts, and the subsequent immune reaction exert different forms of stress and damage to the tissue of the infected host. This stress can trigger specific transcriptional and post-transcriptional programs that have evolved to ...
Wolfgang Vivas +5 more
doaj +1 more source
Evolution of the Unfolded Protein Response in Plants.
Plant, Cell and Environment, 2021 The Unfolded Protein Response (UPR) in plants is elicited by endoplasmic reticulum stress which can be brought about by adverse environmental conditions.
S. Howell
semanticscholar +1 more source
Consensus clustering and functional interpretation of gene-expression data [PDF]
, 2004 Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters.
Kellam, P. +6 more
core +2 more sources
Membrane biogenesis and the unfolded protein response [PDF]
The Journal of Cell Biology, 2004 In addition to serving as the entry point for newly translated polypeptides making their way through the secretory pathway, the endoplasmic reticulum (ER) also synthesizes many lipid components of the entire endomembrane system. A report published in this issue implicates a signaling pathway known to respond to ER unfolded protein load in the control ...
David Ron, Randolph Y. Hampton
openalex +4 more sources
Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]
, 2017 Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J. +4 more
core +2 more sources
Human Genomics, 2021 Highlights 1. We first comprehensive investigated the expression, protein–protein interaction, and prognostic value of unfolded protein response-related gene in bladder cancer. 2.
Ke Zhu +4 more
doaj +1 more source
Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response
Glomerular Diseases, 2022 Background: Fibrillary glomerulonephritis (FGN) is found in approximately 1% of native kidney biopsies and was traditionally defined by glomerular deposition of fibrils larger than amyloid (12–24 nm diameter) composed of polyclonal IgG.
Nicole K. Andeen +5 more
doaj +1 more source
A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]
, 2015 The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego +3 more
core +1 more source