Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia. [PDF]
Cell Mol Biol Lett, 2020 During hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR).
Bartoszewska S, Collawn JF.
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Contribution of the Unfolded Protein Response (UPR) to the Pathogenesis of Proteasome-Associated Autoinflammatory Syndromes (PRAAS). [PDF]
Front Immunol, 2019 Type I interferonopathies cover a phenotypically heterogeneous group of rare genetic diseases including the recently described proteasome-associated autoinflammatory syndromes (PRAAS).
Ebstein F +3 more
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PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR). [PDF]
Cell Death Dis, 2017 Endoplasmic reticulum (ER) stress leads to activation of the unfolded protein response (UPR) that results in transient suppression of protein translation to allow recovery but leads to cell death when stress cannot be resolved.
Kranz P +12 more
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PLoS Pathogens, 2009 Filamentous fungi rely heavily on the secretory pathway, both for the delivery of cell wall components to the hyphal tip and the production and secretion of extracellular hydrolytic enzymes needed to support growth on polymeric substrates.
Daryl L. Richie +11 more
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The unfolded protein response (UPR) pathway in Cryptococcus. [PDF]
Virulence, 2014 Unique and evolutionarily conserved signaling pathways allow an organism to sense, respond to, and adapt to internal and external environmental cues at its biological niche.
Cheon SA, Jung KW, Bahn YS, Kang HA.
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Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells. [PDF]
Int J Mol Sci, 2019 The endoplasmic reticulum (ER) has diverse functions, and especially misfolded protein modification is in the focus of this review paper. With a highly regulatory mechanism, called unfolded protein response (UPR), it protects cells from the accumulation ...
Hsu SK +9 more
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The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer. [PDF]
J Hematol Oncol, 2022 Mitochondria are essential for tumor growth and progression. However, the heavy demand for mitochondrial activity in cancer leads to increased production of mitochondrial reactive oxygen species (mtROS), accumulation of mutations in mitochondrial DNA ...
Inigo JR, Chandra D.
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Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development. [PDF]
Int J Mol Sci, 2019 Mammalian oocytes and early embryos derived from in vitro production are highly susceptible to a variety of cellular stresses. During oocyte maturation and preimplantation embryo development, functional proteins must be folded properly in the endoplasmic
Lin T +5 more
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The Unfolded Protein Response: An Overview
Biology, 2021 The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
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Molecular Neurodegeneration, 2022 Background The retina, as part of the central nervous system (CNS) with limited capacity for self-reparation and regeneration in mammals, is under cumulative environmental stress due to high-energy demands and rapid protein turnover.
Todd McLaughlin +5 more
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