Results 1 to 10 of about 52,959 (267)

The Role of the Hypoxia-Related Unfolded Protein Response (UPR) in the Tumor Microenvironment. [PDF]

Cancers (Basel), 2022
Despite our understanding of the unfolded protein response (UPR) pathways, the crosstalk between the UPR and the complex signaling networks that different cancers utilize for cell survival remains to be, in most cases, a difficult research barrier. A major problem is the constant variability of different cancer types and the different stages of cancer ...
Bartoszewska S, Collawn JF, Bartoszewski R.   +2 more
europepmc   +5 more sources

Editorial: Unfolded protein response (UPR): An impending target for multiple neurological disorders. [PDF]

Front Aging Neurosci, 2022
EDITORIAL article Front. Aging Neurosci., 23 September 2022Sec.
Jan AT, Rahman S, Ahmad K, Minakshi R.
europepmc   +6 more sources

Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR). [PDF]

Int J Mol Sci, 2022
High rates of cell proliferation and protein synthesis in pancreatic cancer are among many factors leading to endoplasmic reticulum (ER) stress. To restore cellular homeostasis, the unfolded protein response (UPR) activates as an adaptive mechanism through either the IRE1α, PERK, or ATF6 pathways to reduce the translational load and process unfolded ...
Botrus G, Miller RM, Uson Junior PLS, Kannan G, Han H, Von Hoff DD.   +5 more
europepmc   +5 more sources

Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR). [PDF]

Curr Res Microb Sci, 2022
Guirao-Abad JP, Weichert M, Askew DS.
europepmc   +2 more sources

PB2393: ACTIVATION OF ER STRESS AND UNFOLDED PROTEIN RESPONSE (UPR) PATHWAYS IN HEPATITIS B VIRUS (HBV) INFECTED B CELLS AND ITS SIGNIFICANCE IN PATHOGENESIS OF B-CELL NON-HODGKIN LYMPHOMAS (B-NHL) [PDF]

Hemasphere, 2023
Uta M, Ghionescu A, Delia Popa C, Nichita N, Coriu D.   +4 more
europepmc   +2 more sources

Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH. [PDF]

Redox Biol
Goossen CJ, Kufner A, Dustin CM, Al Ghouleh I, Yuan S, Straub AC, Sembrat J, Baust JJ, Gomez D, Kračun D, Pagano PJ.   +10 more
europepmc   +3 more sources

Hijacking the unfolded protein response (UPR) pathway: Balancing viral infection and host cell survival. [PDF]

J Biol Chem
Chen H, Liu D, Hua J, Wu M, Hua Y, Feng C, He Z, Moffett P, Zhang K.   +8 more
europepmc   +3 more sources

Inhibition of PERK Kinase, an Orchestrator of the Unfolded Protein Response (UPR), Significantly Reduces Apoptosis and Inflammation of Lung Epithelial Cells Triggered by SARS-CoV-2 ORF3a Protein. [PDF]

Biomedicines, 2023
Keramidas P, Papachristou E, Papi RM, Mantsou A, Choli-Papadopoulou T.   +4 more
europepmc   +3 more sources

Contribution of the Unfolded Protein Response (UPR) to the Pathogenesis of Proteasome-Associated Autoinflammatory Syndromes (PRAAS). [PDF]

Front Immunol, 2019
Ebstein F, Poli Harlowe MC, Studencka-Turski M, Krüger E.   +3 more
europepmc   +3 more sources

An unfolded protein response (UPR)-signature regulated by the NFKB-miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer. [PDF]

Front Mol Biosci
Zhang J, Fan X, Chen Y, Han Y, Yu W, Zhang S, Yang B, Zhang J, Chen Y.   +8 more
europepmc   +2 more sources