Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. [PDF]
PLoS Biology, 2004 Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus.
Christopher K Patil +2 more
doaj +7 more sources
Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks [PDF]
Trends in Biochemical Sciences, 2020 Senescence is a complex cellular state, which can be considered as a stress response phenotype. However, the mechanisms through which cells acquire and maintain this phenotype are not fully understood. In this paper, it is argued that the unfolded protein response (UPR) may represent a signalling platform that is associated with the major senescence ...
Corinne Abbadie, Olivier Pluquet
+7 more sources
Unfolded Protein Response (UPR) Pathway in cutaneous leishmaniasis: A review [PDF]
, 2023 Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol Requiring Enzyme 1 (IRE1), Protein Kinase RNA like ER kinase (PERK), and Activating Transcription Factor 6 (ATF6) to restore ...
Nadira D. Karunaweera +3 more
openalex +2 more sources
“Translating” Tumor Hypoxia: Unfolded Protein Response (UPR)–Dependent and UPR-Independent Pathways [PDF]
Molecular Cancer Research, 2006 Abstract Poor oxygenation (hypoxia) is present in the majority of human tumors and is associated with poor prognosis due to the protection it affords to radiotherapy and chemotherapy. Hypoxia also elicits multiple cellular response pathways that alter gene expression and affect tumor progression, including two recently identified ...
Constantinos Koumenis, Bradly G. Wouters
openalex +4 more sources
Drosophila Unfolded Protein Response (UPR) Assays In Vitro and In Vivo. [PDF]
Methods Mol Biol, 2022 Wildtype or mutant proteins expressed beyond the capacity of a cell's protein folding system could be detrimental to general cellular function and survival. In response to misfolded protein overload in the endoplasmic reticulum (ER), eukaryotic cells activate the Unfolded Protein Response (UPR) that helps cells restore protein homeostasis in the ...
Katow H, Vasudevan D, Ryoo HD.
europepmc +3 more sources
A repurposed drug combination (VaN) inhibits free light chain secretion and triggers the terminal unfolded protein response (UPR) in multiple myeloma (MM) [PDF]
, 2023 Jiang Y +14 more
europepmc +2 more sources
Interplay between autophagy, the unfolded protein response and the cytoplasmic heat stress response during heat stress in maize [PDF]
BMC Plant BiologyBackground High temperatures can substantially reduce plant survival and reproduction, and therefore decrease crop productivity. Plants activate several pathways in response to high temperatures, including the endoplasmic reticulum (ER) unfolded protein ...
Jie Tang +3 more
doaj +2 more sources
Thioredoxin‐interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress [PDF]
EMBO Molecular Medicine, 2014 The endoplasmic reticulum (ER) is responsible for protein folding, modification, and trafficking. Accumulation of unfolded or misfolded proteins represents the condition of ER stress and triggers the unfolded protein response (UPR), a key mechanism ...
Samuel Lee +10 more
doaj +3 more sources
Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model. [PDF]
Oxid Med Cell Longev, 2020 Hosseini M +8 more
europepmc +3 more sources
PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR). [PDF]
Cell Death Dis, 2017 Kranz P +12 more
europepmc +3 more sources