Results 21 to 30 of about 67,514 (293)

ER Stress and Unfolded Protein Response in Leukemia: Friend, Foe, or Both?

Biomolecules, 2021
The unfolded protein response (UPR) is an evolutionarily conserved adaptive signaling pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which is initiated by the accumulation of unfolded proteins.
Kelly Féral, Manon Jaud, Céline Philippe, Doriana Di Bella, Stéphane Pyronnet, Kevin Rouault-Pierre, Laurent Mazzolini, Christian Touriol   +7 more
doaj   +2 more sources

ER stress and unfolded protein response (UPR) signaling modulate GLP-1 receptor signaling in the pancreatic islets. [PDF]

Mol Cells, 2023
Gao Y, Ryu H, Lee H, Kim YJ, Lee JH, Lee J.   +5 more
europepmc   +2 more sources

Author Correction: XBP-1 and the unfolded protein response (UPR) [PDF]

Nature Immunology, 2020
Laurie H. Glimcher, Ann–Hwee Lee, Neal N. Iwakoshi   +2 more
openalex   +3 more sources

The Role of the Hypoxia-Related Unfolded Protein Response (UPR) in the Tumor Microenvironment. [PDF]

Cancers (Basel), 2022
Despite our understanding of the unfolded protein response (UPR) pathways, the crosstalk between the UPR and the complex signaling networks that different cancers utilize for cell survival remains to be, in most cases, a difficult research barrier. A major problem is the constant variability of different cancer types and the different stages of cancer ...
Bartoszewska S, Collawn JF, Bartoszewski R.   +2 more
europepmc   +3 more sources

An unfolded protein response (UPR)-signature regulated by the NFKB-miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer. [PDF]

Front Mol Biosci
Zhang J, Fan X, Chen Y, Han Y, Yu W, Zhang S, Yang B, Zhang J, Chen Y.   +8 more
europepmc   +2 more sources

Redox regulation of lung endothelial PERK, unfolded protein response (UPR) and proliferation via NOX1: Targeted inhibition as a potential therapy for PAH. [PDF]

Redox Biol
Goossen CJ, Kufner A, Dustin CM, Al Ghouleh I, Yuan S, Straub AC, Sembrat J, Baust JJ, Gomez D, Kračun D, Pagano PJ.   +10 more
europepmc   +2 more sources

Thioredoxin‐interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress [PDF]

EMBO Molecular Medicine, 2014
The endoplasmic reticulum (ER) is responsible for protein folding, modification, and trafficking. Accumulation of unfolded or misfolded proteins represents the condition of ER stress and triggers the unfolded protein response (UPR), a key mechanism ...
Samuel Lee, Soo Min Kim, James Dotimas, Letitia Li, Edward P Feener, Stephan Baldus, Ronald B Myers, William A Chutkow, Parth Patwari, Jun Yoshioka, Richard T Lee   +10 more
doaj   +3 more sources

Kisspeptin-10 Improves Testicular Redox Status but Does Not Alter the Unfolded Protein Response (UPR) That Is Downregulated by Hypothyroidism in a Rat Model. [PDF]

Int J Mol Sci
Santos LC, Dos Anjos Cordeiro JM, Cunha MCDSG, Santos BR, Oliveira LS, da Silva AL, Barbosa EM, Niella RV, de Freitas GJC, Santos DA, Serakides R, Ocarino NM, Borges SC, de Lavor MSL, Silva JF.   +14 more
europepmc   +3 more sources

The Unfolded Protein Response (UPR) in Pulmonary Fibrosis; with a Redox Twist [PDF]

D109. MODULATING THE FIBROTIC RESPONSE, 2020
Vikas Anathy, Ashish Kumar, Evan A. Elko, S. Bruno, Z. Mark, Jose L. Gomez Villalobos, N. Chamberlain, Joseph Walzer, Yvonne Janssen‐Heininger   +8 more
openalex   +2 more sources

Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model. [PDF]

Oxid Med Cell Longev, 2020
Hosseini M, Shaygannia E, Rahmani M, Eskandari A, Golsefid AA, Tavalaee M, Gharagozloo P, Drevet JR, Nasr-Esfahani MH.   +8 more
europepmc   +3 more sources