Results 21 to 30 of about 52,959 (267)

Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells. [PDF]

Oncotarget, 2018
Sauzay C, Louandre C, Bodeau S, Anglade F, Godin C, Saidak Z, Fontaine JX, Usureau C, Martin N, Molinie R, Pascal J, Mesnard F, Pluquet O, Galmiche A.   +13 more
europepmc   +3 more sources

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia. [PDF]

Cell Mol Biol Lett, 2020
AbstractDuring hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR). While their induced signaling pathways have many distinct targets, there are some important connections as well.
Bartoszewska S, Collawn JF.
europepmc   +5 more sources

Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease

Biology of the Cell, 2019
AbstractParkinson's disease is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta. At the molecular level, Parkinson's disease share common molecular signatures with most neurodegenerative diseases including the accumulation
Alexis Martínez, Nélida López, Constanza González, Claudio Hetz   +3 more
openalex   +5 more sources

Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR). [PDF]

Cancers (Basel), 2019
Shah SS, Rodriguez GA, Musick A, Walters WM, de Cordoba N, Barbarite E, Marlow MM, Marples B, Prince JS, Komotar RJ, Vanni S, Graham RM.   +11 more
europepmc   +3 more sources

Diclofenac Diminished the Unfolded Protein Response (UPR) Induced by Tunicamycin in Human Endothelial Cells. [PDF]

Molecules, 2022
Diclofenac belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs), which are amongst the most frequently prescribed drugs to treat fever, pain and inflammation. Despite the presence of NSAIDs on the pharmaceutical market for several decades, epidemiological studies have shown new clinical applications of NSAIDs, and new mechanisms of ...
Sokołowska P, Siatkowska M, Jóźwiak-Bębenista M, Komorowski P, Koptas M, Kowalczyk E, Wiktorowska-Owczarek A.   +6 more
europepmc   +4 more sources

A small molecule UPR modulator for diabetes identified by high throughput screening

Acta Pharmaceutica Sinica B, 2021
Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the ...
Valeria Marrocco, Tuan Tran, Siying Zhu, Seung Hyuk Choi, Ana M. Gamo, Sijia Li, Qiangwei Fu, Marta Diez Cunado, Jason Roland, Mitch Hull, Van Nguyen-Tran, Sean Joseph, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay, Weijun Shen   +15 more
doaj   +1 more source

Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells. [PDF]

Int J Mol Sci
De Paoli M, Shah D, Zakharia A, Patel Z, Patel Z, Pakhi P, Werstuck GH.   +6 more
europepmc   +3 more sources

The mitochondrial unfolded protein response (UPR^mt) protects against osteoarthritis. [PDF]

Exp Mol Med, 2022
AbstractThe mitochondrial unfolded protein response (UPRmt) is a mitochondrial-to-nuclear signaling pathway that is activated to maintain mitochondrial function when there is an accumulation of misfolded proteins within mitochondria. Mitochondrial function is essential for chondrocyte homeostasis, and mitochondrial dysfunction is a characteristic of ...
Zhou Z, Lu J, Yang M, Cai J, Fu Q, Ma J, Zhu L.   +6 more
europepmc   +3 more sources

ROS and Endoplasmic Reticulum Stress in Pulmonary Disease

Frontiers in Pharmacology, 2022
Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies show that though specific pulmonary diseases and correlative lung-metabolic deviance own unique pathophysiology and clinical manifestations, they always tend to ...
Xiangning Cui, Yang Zhang, Yingdong Lu, Mi Xiang   +3 more
doaj   +1 more source

Cytoprotective Co-chaperone BcBAG1 Is a Component for Fungal Development, Virulence, and Unfolded Protein Response (UPR) of Botrytis cinerea. [PDF]

Front Microbiol, 2019
Zhang H, Li Y, Dickman MB, Wang Z.
europepmc   +2 more sources