Results 31 to 40 of about 67,514 (293)

Drosophila Unfolded Protein Response (UPR) Assays In Vitro and In Vivo. [PDF]

Methods Mol Biol, 2022
Wildtype or mutant proteins expressed beyond the capacity of a cell's protein folding system could be detrimental to general cellular function and survival. In response to misfolded protein overload in the endoplasmic reticulum (ER), eukaryotic cells activate the Unfolded Protein Response (UPR) that helps cells restore protein homeostasis in the ...
Katow H, Vasudevan D, Ryoo HD.
europepmc   +3 more sources

Control of mammalian brain aging by the unfolded protein response (UPR) [PDF]

, 2020
AbstractAging is the major risk factor for the development of dementia and neurodegenerative disorders, and the aging brain manifests severe deficits in buffering capacity by the proteostasis network. Accordingly, we investigated the significance of the unfolded protein response (UPR), a major signaling pathway that copes with endoplasmic reticulum (ER)
Felipe Cabral‐Miranda, Giovani Tamburini, Gabriela Martínez, Danilo B. Medinas, Yannis Gerakis, Tim Miedema, Claudia Duran‐Aniotz, Álvaro O. Ardiles, Cristóbal González, Carleen Mae P. Sabusap, Francisca Bermedo‐García, Stuart Adamson, Kaitlyn Vitangcol, Hernán Huerta, Xu Zhang, Tomohiro Nakamura, S. Pablo Sardi, Stuart A. Lipton, Brian K. Kenedy, César Cárdenas, Adrián G. Palacios, Lars Plate, Juan Pablo Henríquez, Claudio Hetz   +23 more
openalex   +3 more sources

Thapsigargin and Tunicamycin Block SARS-CoV-2 Entry into Host Cells via Differential Modulation of Unfolded Protein Response (UPR), AKT Signaling, and Apoptosis. [PDF]

Cells
Al Otaibi A, Al Shaikh Mubarak S, Al Hejji F, Almasaud A, Al Jami H, Iqbal J, Al Qarni A, Harbi NKA, Bakillah A.   +8 more
europepmc   +2 more sources

28* Study of the unfolded protein response (UPR) in cystic fibrosis (CF)

Journal of Cystic Fibrosis, 2007
n ...
Mathieu Kerbiriou, Pascal Trouvé, Claude Férec   +2 more
openalex   +4 more sources

PB2393: ACTIVATION OF ER STRESS AND UNFOLDED PROTEIN RESPONSE (UPR) PATHWAYS IN HEPATITIS B VIRUS (HBV) INFECTED B CELLS AND ITS SIGNIFICANCE IN PATHOGENESIS OF B-CELL NON-HODGKIN LYMPHOMAS (B-NHL) [PDF]

Hemasphere, 2023
Uta M, Ghionescu A, Delia Popa C, Nichita N, Coriu D.   +4 more
europepmc   +2 more sources

Unfolded Protein Response (UPR) is activated during normal lens development [PDF]

Gene Expression Patterns, 2010
The lens of the eye is a transparent structure responsible for focusing light onto the retina. It is composed of two morphologically different cell types, epithelial cells found on the anterior surface and the fiber cells that are continuously formed by the differentiation of epithelial cells at the lens equator.
Zeynep Fırtına Karagonlar, Melinda K. Duncan   +1 more
openalex   +4 more sources

Diclofenac Diminished the Unfolded Protein Response (UPR) Induced by Tunicamycin in Human Endothelial Cells. [PDF]

Molecules, 2022
Diclofenac belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs), which are amongst the most frequently prescribed drugs to treat fever, pain and inflammation. Despite the presence of NSAIDs on the pharmaceutical market for several decades, epidemiological studies have shown new clinical applications of NSAIDs, and new mechanisms of ...
Sokołowska P, Siatkowska M, Jóźwiak-Bębenista M, Komorowski P, Koptas M, Kowalczyk E, Wiktorowska-Owczarek A.   +6 more
europepmc   +4 more sources

Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells. [PDF]

Int J Mol Sci
De Paoli M, Shah D, Zakharia A, Patel Z, Patel Z, Pakhi P, Werstuck GH.   +6 more
europepmc   +3 more sources

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA [PDF]

Cell Death & Disease, 2014
Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and ...
Marco J. Herold, Lorraine A. O’Reilly, Chien‐Huang Lin, Rahul Srivastava, Marcel Doerflinger, Philippe Bouillet, Andreas Strasser, Hamsa Puthalakath   +7 more
openalex   +5 more sources

COMPARISON OF BiP AND Hsp70i AS MARKERS OF UNFOLDED PROTEIN RESPONSE (UPR) IN SEGMENTAL AND NONSEGMENTAL VITILIGO [PDF]

F1000Research, 2022
Background: Unfolded protein response (UPR) is a misfolded protein that occurs because oxidative stress disrupts cellular redox potential that extends to the endoplasmic reticulum (ER). Binding immunoglobulin protein (BiP) and inducible heat shock protein (HSP70i) as ER chaperons play critical roles in melanocyte apoptosis.
Boedhy Setyanto, Kalim Handono, Sri Poeranto, Dhelya Widasmara   +3 more
openalex   +4 more sources