Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases
Frontiers in Immunology, 2020 The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and plays an important role in cellular functions. The unfolded protein response (UPR) is activated in response to misfolded or unfolded protein accumulation in the ER.
Ji-Ae Choi +5 more
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Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption [PDF]
Toxicology and Applied Pharmacology, 2013 Arsenic exposure is known to disrupt innate immune functions in humans and in experimental animals. In this study, we provide a mechanism by which arsenic trioxide (ATO) disrupts macrophage functions. ATO treatment of murine macrophage cells diminished internalization of FITC-labeled latex beads, impaired clearance of phagocytosed fluorescent bacteria ...
Ritesh K. Srivastava +10 more
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Crosstalk Between ER Stress, Autophagy and Inflammation
Frontiers in Medicine, 2021 The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but also plays a critical role in sensing cellular stress and maintaining cellular homeostasis.
Sandhya Chipurupalli +2 more
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The unfolded protein response (UPR) pathway in Cryptococcus. [PDF]
Virulence, 2014 Unique and evolutionarily conserved signaling pathways allow an organism to sense, respond to, and adapt to internal and external environmental cues at its biological niche. In eukaryotic cells, the unfolded protein response (UPR) pathway regulates endoplasmic reticulum (ER) homeostasis upon exposure to environmental changes causing ER stress.
Cheon SA, Jung KW, Bahn YS, Kang HA.
europepmc +4 more sources
Reducing erythroblast apoptosis in β-thalassemia via unfolded protein response (UPR) signaling
Medical Hypotheses, 2023 Egarit Noulsri, Surada Lerdwana
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The Unfolded Protein Response: An Overview
Biology, 2021 The unfolded protein response is the mechanism by which cells control endoplasmic reticulum (ER) protein homeostasis. Under normal conditions, the UPR is not activated; however, under certain stresses, such as hypoxia or altered glycosylation, the UPR ...
Adam Read, Martin Schröder
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Unfolded Protein Response (UPR) is activated during normal lens development [PDF]
Gene Expression Patterns, 2011 The lens of the eye is a transparent structure responsible for focusing light onto the retina. It is composed of two morphologically different cell types, epithelial cells found on the anterior surface and the fiber cells that are continuously formed by the differentiation of epithelial cells at the lens equator.
Zeynep, Firtina, Melinda K, Duncan
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Nature Communications, 2022 Endoplasmic reticulum stress activates the unfolded protein response (UPR). The authors show that glucose extends the lifespan of aged animals by activating the otherwise quiescent UPR while causing a UPR-dependent reduced longevity in young ...
Caroline Beaudoin-Chabot +9 more
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Understanding the Unfolded Protein Response (UPR) Pathway: Insights into Neuropsychiatric Disorders and Therapeutic Potentials. [PDF]
Biomol Ther (Seoul)The Unfolded Protein Response (UPR) serves as a critical cellular mechanism dedicated to maintaining protein homeostasis, primarily within the endoplasmic reticulum (ER). This pathway diligently responds to a variety of intracellular indicators of ER stress with the objective of reinstating balance by diminishing the accumulation of unfolded proteins ...
Kim P.
europepmc +3 more sources
Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP. [PDF]
Oncotarget, 2017 Lev A +11 more
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