Results 41 to 50 of about 67,514 (293)

Editorial: Unfolded protein response (UPR): An impending target for multiple neurological disorders. [PDF]

Front Aging Neurosci, 2022
EDITORIAL article Front. Aging Neurosci., 23 September 2022Sec.
Jan AT, Rahman S, Ahmad K, Minakshi R.
europepmc   +4 more sources

Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes. [PDF]

Cell Death Discov, 2018
Wärri A, Cook KL, Hu R, Jin L, Zwart A, Soto-Pantoja DR, Liu J, Finkel T, Clarke R.   +8 more
europepmc   +3 more sources

Cytoprotective Co-chaperone BcBAG1 Is a Component for Fungal Development, Virulence, and Unfolded Protein Response (UPR) of Botrytis cinerea. [PDF]

Front Microbiol, 2019
Zhang H, Li Y, Dickman MB, Wang Z.
europepmc   +3 more sources

ROS and Endoplasmic Reticulum Stress in Pulmonary Disease

Frontiers in Pharmacology, 2022
Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies show that though specific pulmonary diseases and correlative lung-metabolic deviance own unique pathophysiology and clinical manifestations, they always tend to ...
Xiangning Cui, Yang Zhang, Yingdong Lu, Mi Xiang   +3 more
doaj   +1 more source

Insights Into the Role of Endoplasmic Reticulum Stress in Infectious Diseases

Frontiers in Immunology, 2020
The endoplasmic reticulum (ER) is the major organelle in the cell for protein folding and plays an important role in cellular functions. The unfolded protein response (UPR) is activated in response to misfolded or unfolded protein accumulation in the ER.
Ji-Ae Choi, Ji-Ae Choi, Ji-Ae Choi, Chang-Hwa Song, Chang-Hwa Song, Chang-Hwa Song   +5 more
doaj   +1 more source

Crosstalk Between ER Stress, Autophagy and Inflammation

Frontiers in Medicine, 2021
The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but also plays a critical role in sensing cellular stress and maintaining cellular homeostasis.
Sandhya Chipurupalli, Unni Samavedam, Nirmal Robinson   +2 more
doaj   +1 more source

Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? [PDF]

, 2015
Mitochondrial unfolded protein response is a form of retrograde signaling that contributes to ensuring the maintenance of quality control of mitochondria, allowing functional integrity of the mitochondrial proteome. When misfolded proteins or unassembled
Arnould, T., Michel, S., Renard, P.
core   +6 more sources

The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans

Nature Communications, 2022
Endoplasmic reticulum stress activates the unfolded protein response (UPR). The authors show that glucose extends the lifespan of aged animals by activating the otherwise quiescent UPR while causing a UPR-dependent reduced longevity in young ...
Caroline Beaudoin-Chabot, Lei Wang, Cenk Celik, Aishah Tul-Firdaus Abdul Khalid, Subhash Thalappilly, Shiyi Xu, Jhee Hong Koh, Venus Wen Xuan Lim, Ann Don Low, Guillaume Thibault   +9 more
doaj   +1 more source

UPR Signal Activation by Luminal Sensor Domains [PDF]

, 2013
The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis.
Ali, Maruf, Carrara, Marta, Prischi, Filippo   +2 more
core   +1 more source

Investigation of the Molecular Mechanisms Leading to Protein Translation Inhibition in Response to Endoplasmic Reticulum Stress

مجلة المختار للعلوم, 2018
Protein folding is an important process for cellular function. ER is responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins.
Abdulsalam Elfowiris, Terence P. Herbert   +1 more
doaj   +1 more source