Results 41 to 50 of about 52,959 (267)

UPR Signal Activation by Luminal Sensor Domains [PDF]

, 2013
The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis.
Ali, Maruf, Carrara, Marta, Prischi, Filippo   +2 more
core   +1 more source

The Protective Effect of a Newly Developed Molecular Chaperone– Inducer Against Mouse Ischemic Acute Kidney Injury

Journal of Pharmacological Sciences, 2009
Activation of the unfolded protein response (UPR) has been suggested to attenuate renal ischemia-reperfusion (I/R) injury. We recently found a compound, namely BIX, that activated the UPR selectively through the activating transcription factor 6 pathway.
Worapat Prachasilchai, Hiroko Sonoda, Naoko Yokota-Ikeda, Katsuaki Ito, Takashi Kudo, Kazunori Imaizumi, Masahiro Ikeda   +6 more
doaj   +1 more source

Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle

Nature Communications, 2022
Endoplasmic Reticulum stress induces cell non-autonomous Unfolded Protein Response (UPR) activation. Here the authors show that long-chain ceramides are secreted from muscle cells in extracellular vesicles and induce cell non-autonomous UPR activation in
Ben D. McNally, Dean F. Ashley, Lea Hänschke, Hélène N. Daou, Nicole T. Watt, Steven A. Murfitt, Amanda D. V. MacCannell, Anna Whitehead, T. Scott Bowen, Francis W. B. Sanders, Michele Vacca, Klaus K. Witte, Graeme R. Davies, Reinhard Bauer, Julian L. Griffin, Lee D. Roberts   +15 more
doaj   +1 more source

Ricin-A-chain (RTA) inhibits the unfolded protein response (UPR) in mammalian cells

, 2010
Ricin, a type II ribosome-inactivating protein, has been used as a biochemical weapon due to its ability to inhibit protein synthesis and induce cytotoxicity. The unfolded protein response (UPR) is a survival response that helps cells to recover from stress that occurs following the accumulation of misfolded proteins in the ER.
Chao-Ting Wang
openalex   +2 more sources

Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? [PDF]

, 2015
Mitochondrial unfolded protein response is a form of retrograde signaling that contributes to ensuring the maintenance of quality control of mitochondria, allowing functional integrity of the mitochondrial proteome. When misfolded proteins or unassembled
Arnould, T., Michel, S., Renard, P.
core   +3 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

An unfolded protein-induced conformational switch activates mammalian IRE1. [PDF]

, 2017
The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells.
Acosta-Alvear, Diego, Chu, Feixia, Karagöz, G Elif, Lee, Crystal P, Nguyen, Hieu T, Walter, Peter   +5 more
core   +3 more sources

Investigation of the Molecular Mechanisms Leading to Protein Translation Inhibition in Response to Endoplasmic Reticulum Stress

مجلة المختار للعلوم, 2018
Protein folding is an important process for cellular function. ER is responsible for the synthesis, folding, modification, and quality control of numerous secretory and membrane proteins.
Abdulsalam Elfowiris, Terence P. Herbert   +1 more
doaj   +1 more source

Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion InjurySummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Intestinal ischemia-reperfusion injury is a serious and life-threatening condition. A better understanding of molecular mechanisms related to intestinal ischemia-reperfusion injury in human beings is imperative to find therapeutic ...
Anna M. Kip, Joep Grootjans, Marco Manca, M’hamed Hadfoune, Bas Boonen, Joep P.M. Derikx, Erik A.L. Biessen, Steven W.M. Olde Damink, Cornelis H.C. Dejong, Wim A. Buurman, Kaatje Lenaerts   +10 more
doaj   +1 more source

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]

, 2016
Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene, Coucke, Céline, Devisscher, Lindsey, Geerts, Anja, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vandierendonck, Aster, Verhelst, Xavier   +12 more
core   +2 more sources