Novel Platforms for the Development of a Universal Influenza Vaccine [PDF]
Frontiers in Immunology, 2018 Despite advancements in immunotherapeutic approaches, influenza continues to cause severe illness, particularly among immunocompromised individuals, young children, and elderly adults.
Arun Kumar +5 more
doaj +5 more sources
Progress towards the Development of a Universal Influenza Vaccine [PDF]
Viruses, 2022 Influenza viruses are responsible for millions of cases globally and significantly threaten public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 years and some of the viruses have resulted in high mortality in humans ...
Wen-Chien Wang +3 more
doaj +2 more sources
Immunogenic epitope prediction to create a universal influenza vaccine [PDF]
Heliyon, 2022 Influenza virus is one of the most rapidly evolving human pathogens and causes significant morbidity and mortality worldwide. This feature enables the virus to avoid natural or vaccine-induced immunity.
R.R. Mintaev +3 more
doaj +2 more sources
Research Progress of Universal Influenza Vaccine [PDF]
VaccinesInfluenza viruses continue to undergo antigenic drift and shift, resulting in the need to update existing vaccines annually. Therefore, the development of a universal influenza vaccine has become an urgent global need. This paper reviews the functions of
Liangliang Wang +7 more
doaj +2 more sources
Strategies Targeting Hemagglutinin as a Universal Influenza Vaccine [PDF]
Vaccines, 2021 Influenza virus has significant viral diversity, both through antigenic drift and shift, which makes development of a vaccine challenging. Current influenza vaccines are updated yearly to include strains predicted to circulate in the upcoming influenza ...
Brianna L. Bullard, Eric A. Weaver
doaj +2 more sources
Beyond clinical trials: Evolutionary and epidemiological considerations for development of a universal influenza vaccine. [PDF]
PLoS Pathogens, 2020 The prospect of universal influenza vaccines is generating much interest and research at the intersection of immunology, epidemiology, and viral evolution.
Cécile Viboud +9 more
doaj +2 more sources
Exploring the potential public health benefits of universal influenza vaccine [PDF]
Human Vaccines & Immunotherapeutics, 2019 Background: Broadly protective, long-lasting universal influenza vaccines are under development in response to low-moderate seasonal vaccine effectiveness, frequent genetic changes in circulating viruses and extended turnaround for vaccine manufacture ...
Jay V. DePasse +6 more
doaj +2 more sources
The effect of respiratory viruses on immunogenicity and protection induced by a candidate universal influenza vaccine in mice. [PDF]
PLoS ONE, 2019 Current approaches to influenza control rely on vaccines matched to viruses in circulation. Universal influenza vaccines would offer the advantage of providing broad protection against diverse strains of influenza virus.
Janelle Rowell +7 more
doaj +2 more sources
Will the public take a universal influenza vaccine?: the need for social and behavioral science research [PDF]
Human Vaccines & Immunotherapeutics, 2020 Every influenza season, uptake of the flu vaccine falls short of the Healthy People 2020 goal of at least 70% of adults being vaccinated. Mixed methods research finds multiple factors associated with this phenomenon including misconceptions about the ...
Sandra Crouse Quinn, Amelia Jamison
doaj +2 more sources
Towards a universal influenza vaccine: different approaches for one goal [PDF]
Virology Journal, 2018 Influenza virus infection is an ongoing health and economic burden causing epidemics with pandemic potential, affecting 5–30% of the global population annually, and is responsible for millions of hospitalizations and thousands of deaths each year. Annual
Giuseppe A. Sautto +2 more
doaj +2 more sources