Results 41 to 50 of about 50,051 (221)
Applying Unique Molecular Identifiers in Next Generation Sequencing Reveals a Constrained Viral Quasispecies Evolution under Cross-Reactive Antibody Pressure Targeting Long Alpha Helix of Hemagglutinin. [PDF]
, 2018 To overcome yearly efforts and costs for the production of seasonal influenza vaccines, new approaches for the induction of broadly protective and long-lasting immune responses have been developed in the past decade. To warrant safety and efficacy of the
Farinelle, S +9 more
core +2 more sources
Influenza and Universal Vaccine Research in China
Viruses, 2022 Influenza viruses usually cause seasonal influenza epidemics and influenza pandemics, resulting in acute respiratory illness and, in severe cases, multiple organ complications and even death, posing a serious global and human health burden. Compared with other countries, China has a large population base and a large number of influenza cases and deaths.
Jiali Li +3 more
openaire +3 more sources
mBio, 2015 Influenza virus infections are a global public health problem, with a significant impact of morbidity and mortality from both annual epidemics and pandemics.
Louis M. Schwartzman +5 more
doaj +1 more source
Self-Assembly M2e-Based Peptide Nanovaccine Confers Broad Protection Against Influenza Viruses
Frontiers in Microbiology, 2020 The extracellular domain of influenza M2 protein (M2e) is highly conserved and is a promising target for development of universal influenza vaccines. Here, we synthesized a peptide vaccine consisting of M2e epitope linked to a fibrillizing peptide, which
Qimin Wang +9 more
doaj +1 more source
Virus-like particles as universal influenza vaccines [PDF]
Expert Review of Vaccines, 2012 Current influenza vaccines are primarily targeted to induce immunity to the influenza virus strain-specific hemagglutinin antigen and are not effective in controlling outbreaks of new pandemic viruses. An approach for developing universal vaccines is to present highly conserved antigenic epitopes in an immunogenic conformation such as virus-like ...
Sang-Moo, Kang +2 more
openaire +2 more sources
Novel universal influenza virus vaccine approaches [PDF]
Current Opinion in Virology, 2016 Seasonal influenza virus vaccines have to be re-formulated and re-administered on an annual basis due to antigenic drift of the influenza virus surface glycoproteins. In addition, seasonal vaccines show limited efficacy against novel pandemic influenza virus strains, and producing tailored vaccines for these strains in a timely manner is challenging ...
openaire +2 more sources
Progress on adenovirus-vectored universal influenza vaccines [PDF]
Human Vaccines & Immunotherapeutics, 2015 Influenza virus (IFV) infection causes serious health problems and heavy financial burdens each year worldwide. The classical inactivated influenza virus vaccine (IIVV) and live attenuated influenza vaccine (LAIV) must be updated regularly to match the new strains that evolve due to antigenic drift and antigenic shift.
Kui, Xiang +6 more
openaire +2 more sources
mLife, 2023 Current influenza vaccines need to be updated annually owing to constant antigenic drift in the globular head of the viral surface hemagglutinin (HA) glycoprotein. The immunogenic subdominant stem domain of HA is highly conserved and can be recognized by
Yulei Li +5 more
doaj +1 more source
Influenza and memory T cells : how to awake the force [PDF]
, 2016 Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen +12 more
core +3 more sources
Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head [PDF]
, 2016 Influenza viruses have a huge impact on public health. Current influenza vaccines need to be updated annually and protect poorly against antigenic drift variants or novel emerging subtypes.
Rimmelzwaan, G.F. (Guus) +2 more
core +1 more source