Results 141 to 150 of about 22,011 (155)
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Regulation of cell signalling by uPAR
Nature Reviews Molecular Cell Biology, 2010Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. uPAR regulates proteolysis by binding the extracellular protease urokinase-type plasminogen activator (uPA; also known as urokinase) and also activates many ...
Harvey W, Smith, Chris J, Marshall
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Targeting uPA/uPAR in prostate cancer
Cancer Treatment Reviews, 2007Prostate cancer (CaP) is one of the most common malignancies in men, with an increasing incidence. Despite significant advances in surgery, chemotherapy and radiotherapy to treat CaP, many patients unfortunately succumb to secondary disease (metastases).
Y, Li, P J, Cozzi
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uPAR in angiogenesis regulation
Blood, 2011In this issue of Blood , Brunner and colleagues demonstrate that uPAR, the urokinase plasminogen activator (uPA) receptor that drives endothelial invasion and proliferation in the initial phases of angiogenesis, undergoes down-regulation by density-enhanced phosphatase-1 (DEP-1) in ...
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Thrombosis and Haemostasis, 2013
doi:10.1160/TH13-01-0001 Thromb Haemost 2013; 109: 179 TH 109: 309-318. Transmembrane proteins usually relay signals to the cytoplasm and nucleus via their intracellular domains. Nonetheless, this paradigm is challenged by glycosylphosphatidylinositol (GPI)-anchored proteins.
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doi:10.1160/TH13-01-0001 Thromb Haemost 2013; 109: 179 TH 109: 309-318. Transmembrane proteins usually relay signals to the cytoplasm and nucleus via their intracellular domains. Nonetheless, this paradigm is challenged by glycosylphosphatidylinositol (GPI)-anchored proteins.
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uPA and uPAR in fibrinolysis, immunity and pathology
Trends in Immunology, 2004Abstract The urokinase plasminogen activator (uPA) and its receptor (uPAR) exert pleiotropic functions over the course of both physiological and pathological processes. Data generated in deficient mice have underlined how uPA not only has a key role in fibrinolysis but also modulates the development of protective immunity.
Anna, Mondino, Francesco, Blasi
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Measuring uPAR Dynamics in Live Cells
2008Urokinase-type plasminogen activator receptor (uPAR) is a key component of the urokinase plasminogen activation (uPA) system, which plays important roles in physiological processes as well as in tumor invasion and metastasis. Besides uPAR’s well-established role in the regulation of pericellular proteolysis, a large body of evidences suggests that ...
Moreno Zamai +2 more
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Development of Cyclic Peptide‐Based Radiotracers for uPAR
ChemMedChemAbstractThe urokinase plasminogen activator (uPA) system has garnered attention as a promising biomarker, with the uPA receptor (uPAR) playing a central role in system regulation and demonstrating strong associations with tumorigenicity, invasion, and metastasis.
Xingkai Wang +9 more
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ID: 86 Structural basis of uPAR-uPA and uPAR-vitronectin interactions
Journal of Thrombosis and Haemostasis, 2006M. Huang +9 more
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