Results 91 to 100 of about 75,036 (262)

The Intraoperative Microlesion Effect Positively Correlates With the Short‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost   +8 more
wiley   +1 more source

ATF6 inhibition suppresses the protective effects of pasireotide in human and bovine endothelial cells

Vascular Biology
Activating transcription factor 6 (ATF6) is an unfolded protein response sensor with a significant role in endothelial integrity and barrier function.
Saikat Fakir, Md Matiur Rahman Sarker, Madan Sigdel, Nektarios Barabutis   +3 more
doaj   +1 more source

Inhomogeneous spatial distribution of the magnetic transition in an iron-rhodium thin film

Nature Communications, 2017
Films of iron-rhodium alloy undergo a magnetic transition at 100°C, and so are attractive for applications, but a detailed understanding of the transition mechanism has not been achieved.
C. Gatel, B. Warot-Fonrose, N. Biziere, L.A. Rodríguez, D. Reyes, R. Cours, M. Castiella, M.J. Casanove   +7 more
doaj   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

An exergy approach to efficiency evaluation of desalination [PDF]

, 2017
This paper presents an evaluation process efficiency based on the consumption of primary energy for all types of practical desalination methods available hitherto.
Hamed, Osman A., Ng, Kim Choon, Shahzad, Muhammad Wakil, Son, Hyuk Soo   +3 more
core   +2 more sources

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

The Unfolded Protein Response in Amelogenesis and Enamel Pathologies [PDF]

, 2017
During the secretory phase of their life-cycle, ameloblasts are highly specialized secretory cells whose role is to elaborate an extracellular matrix that ultimately confers both form and function to dental enamel, the most highly mineralized of all ...
Barron, Bartlett, Basseri, Brookes, Brookes, Brookes, Brookes, Chen, Chlubek, Coelho, Credle, Den Besten, Denny, Dey, DiGiuseppe, Dobson, Eletto, Fava, Fribley, Galvan, Gardner, Gonzales, Gregersen, Han, Harding, Hassunuma, Hetz, Hetz, Hetz, Hollien, Hu, Inkielewicz-Stepniak, Iwasaki, Joseph, Joseph, Joseph, Kim, Kimata, Kopito, Kubota, Lacruz, Lakshminarayanan, Lee, Li, Li, Lin, Malhotra, Malhotra, Matsuo, Melchior, Moore, Moore, Moradian-Oldak, Moukdar, Nishio, Nomura, Novosyadlyy, Oakes, Ow, Ozcan, Paine, Prischi, Puthalakath, Reith, Ron, Rutkowski, Ryu, Santos, Schonthal, Schroder, Schubert, Selkoe, Sharma, Sharma, Sire, Smith, Smith, Smith, Smith, Su, Suzuki, Suzuki, Tabas, Tanabe, Teske, Tsuchiya, Tsuru, Tye, Upton, Valastyan, Vilatoba, Wang, Wei, Wu, Yam, Yoshida, Yue, Zhu, Zode   +98 more
core   +2 more sources

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Potential for therapeutic manipulation of the UPR in disease [PDF]

, 2013
Increased endoplasmic reticulum (ER) stress and the activated unfolded protein response (UPR) signaling associated with it play key roles in physiological processes as well as under pathological conditions.
Ozcan, Umut, Park, Sang Won
core   +2 more sources

Western diet leads to aging-related tumorigenesis via activation of the inflammatory, UPR, and EMT pathways [PDF]

, 2021
Ricardo Imbroisi Filho, Alan Clavelland Ochioni, Amanda M. Esteves, João Gabriel Bernardo Leandro, Thainá M. Demaria, Mauro Sola‐Penna, Patrícia Zancan   +6 more
openalex   +1 more source