Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]
, 2018 Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille +12 more
core +2 more sources
Systematic Analysis of the Aberrances and Functional Implications of UPR in Hepatocellular Carcinoma [PDF]
, 2023 Xuan Xu +5 more
openalex +1 more source
Global Change Biology Communications, EarlyView.Embryos are particularly sensitive to thermal challenge. Antarctic fish embryos raised at projected Southern Ocean temperatures hatch during the winter, have a high incidence of morphological abnormalities, have shorter body lengths, and express genes indicative of cellular stress.
Margaret Streeter +6 more
wiley +1 more source
Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease
Frontiers in Cell and Developmental Biology, 2017 Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality control to maintain homeostasis under different conditions and disease states characterized by cell stress.
Dan Lindholm +6 more
doaj +1 more source
Discrete rate maximisation power allocation with enhanced BER [PDF]
, 2012 This study aims to maximise the rate over a multiple-in multiple-out (MIMO) link using incremental power and bit allocation. Two different schemes, greedy power allocation (GPA) and greedy bit allocation (GBA), are addressed and compared with the ...
Alhanafy, Waleed Eid Abdelrahman +1 more
core +1 more source
The unfolded protein response in multiple sclerosis
Frontiers in Neuroscience, 2015 The unfolded protein response (UPR) occurs in response to endoplasmic reticulum (ER) stress caused by the accumulation of unfolded or misfolded proteins in the ER.
Wensheng eLin, Sarrabeth eStone
doaj +1 more source
Neuroprotection targeting protein misfolding on chronic cerebral hypoperfusion in the context of metabolic syndrome [PDF]
, 2018 Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH
Capani, Francisco +6 more
core +1 more source
Sec62 promotes gastric cancer metastasis through mediating UPR-induced autophagy activation
, 2022 Song Su +10 more
openalex +2 more sources
Unfolded Protein Response (UPR) Pathway in cutaneous leishmaniasis: A review [PDF]
, 2023 Nadira D. Karunaweera +3 more
openalex +1 more source
Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss
iMetaMed, EarlyView.As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu +6 more
wiley +1 more source