Results 121 to 130 of about 75,036 (262)
The Effect of Resistance Training and Berberine Chloride on the Apoptosis- Related UPR Signaling Pathway in the Hippocampus of Diazinon- Poisoned Rats [PDF]
, 2021 Ali Esfandiarifar +3 more
openalex +1 more source
iNew Medicine, EarlyView.ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi +14 more
wiley +1 more source
tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. [PDF]
, 2019 Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR).
Peschek, Jirka, Walter, Peter
core
More than proteins for empty stomachs: Wild meat in the BaTonga food system
People and Nature, EarlyView.Abstract Our paper highlights the limitations of the framework used by many conservation‐focused programmes that incorporate food security objectives. This framework encourages the substitution of wild proteins with domestic proteins by promoting animal farming in communities located near conservation areas.
Muriel Figuié +5 more
wiley +1 more source
Frontiers in Endocrinology, 2018 Cells react to a variety of stresses, including accumulation of unfolded or misfolded protein, by activating the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR).
Mara Livezey +3 more
doaj +1 more source
Scope ambiguities, monads and strengths
, 2016 In this paper, we will discuss three semantically distinct scope assignment strategies: traditional movement strategy, polyadic approach, and continuation-based approach.
Grudzinska, Justyna, Zawadowski, Marek
core +2 more sources
Hemophilia A: An Ideal Disease for Prenatal Therapy
Prenatal Diagnosis, EarlyView.ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada +2 more
wiley +1 more source
Analysis of Clp1-dependent UPR modulation in Ustilago maydis [PDF]
, 2019 Niko Pinter
openalex +1 more source
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR
, 2021 Hannah C. Feldman +12 more
openalex +2 more sources
Nasal Delivery of mRNA Using Thermoresponsive Gellable Aqueous Biphasic Systems
Small, EarlyView.Nasal delivery of mRNA using gellable aqueous biphasic systems (ABS) represents a noninvasive alternative while reducing the need for trained professionals and cold chain storage. Composed of gelatin, PEG, and water, these thermoresponsive hydrogels ensure controlled mRNA delivery and prolonged retention at the nasal mucosa, improving transfection ...
Bojan Kopilovic +4 more
wiley +1 more source