Results 71 to 80 of about 75,036 (262)
Exocytosis and endocytosis in neurodocrine cells: inseparable membranes !
Frontiers in Endocrinology, 2013 Although much has been learned concerning the mechanisms of secretory vesicle formation and fusion at donor and acceptor membrane compartments, relatively little attention has been paid towards understanding how cells maintain a homeostatic membrane ...
Sébastien eHouy +8 more
doaj +1 more source
Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure [PDF]
, 2015 Hepatocellular carcinoma (HCC) is characterized by the accumulation of unfolded proteins in the endoplasmic reticulum (ER), which activates the unfolded protein response (UPR).
Ampe, Christophe +16 more
core +3 more sources
An Opto‐Actuated Hydrogel for Cell Mechanoactuation and Real‐Time Force Monitoring
Advanced Science, EarlyView.Researchers developed a mechanoactuated hydrogel interface where nanomachines exert forces on adhesion receptors and allow monitoring of traction force responses in real time. They demonstrate reversible talin recruitment, enhanced F‐actin polymerization, and a reduction in cell traction force when force is locally applied to focal adhesions of ...
Rinku Kumar +6 more
wiley +1 more source
The biological meaning of the UPR [PDF]
Nature Reviews Molecular Cell Biology, 2013 Artículo de publicación ...
openaire +3 more sources
UPR activation alters chemosensitivity of tumor cells [PDF]
Cancer Biology & Therapy, 2006 A growing body of literature demonstrates that the unfolded protein response (UPR) is activated in a number of tumors. Recent data suggests that the UPR may play a role in protecting transformed cells from the inadequate environment that exists prior to vascularization and therefore contribute to tumor growth and survival.
Melissa J, Mann, Linda M, Hendershot
openaire +2 more sources
Advanced Science, EarlyView.This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan +16 more
wiley +1 more source
Disease Models & Mechanisms, 2014 The unfolded protein response (UPR) is a complex network of sensors and target genes that ensure efficient folding of secretory proteins in the endoplasmic reticulum (ER). UPR activation is mediated by three main sensors, which regulate the expression of
Ana M. Vacaru +8 more
doaj +1 more source
Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. [PDF]
, 2013 Miner1 is a redox-active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan.
Andreyev, Alexander Y +12 more
core +1 more source
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Adaptive User Perspective Rendering for Handheld Augmented Reality
, 2017 Handheld Augmented Reality commonly implements some variant of magic lens rendering, which turns only a fraction of the user's real environment into AR while the rest of the environment remains unaffected.
Grubert, Jens +4 more
core +1 more source