Results 11 to 20 of about 8,610 (171)

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N¹-Methylpseudouridine Triphosphate. [PDF]

Angew Chem Int Ed Engl
Pseudouridine‐5′‐triphosphate (ΨTP) and its N1‐methylated derivative (m1ΨTP) are crucial components in mRNA vaccine technology. Here, an atom‐economic, high‐yielding biocatalytic route for ΨTP synthesis is presented. A new chemoenzymatic route for m1ΨTP synthesis was developed.
Pfeiffer M, Krammer L, Zöhrer J, Breinbauer R, Nidetzky B.   +4 more
europepmc   +2 more sources

APOBEC3G protects the genome of human cultured cells and mice from radiation‐induced damage

The FEBS Journal, Volume 290, Issue 7, Page 1822-1839, April 2023., 2023
A3G protects mice from IR‐induced damage and promotes accurate DNA double‐strand breaks repair in cultured cells. Transgenic mice expressing A3G successfully survived lethal irradiation, whereas wild‐type controls quickly succumbed to radiation syndrome.
Yelena Britan‐Rosich, Jing Ma, Eran Kotler, Faizan Hassan, Alexander Botvinnik, Yoav Smith, Ofra Moshel, Abed Nasereddin, Gunjan Sharma, Eli Pikarsky, Susan Ross, Moshe Kotler   +11 more
wiley   +1 more source

Recent Advances in the Development and Synthesis of Carbohydrate‐Based Molecules with Promising Antibacterial Activity

European Journal of Organic Chemistry, Volume 26, Issue 4, January 24, 2023., 2023
In this review, the potential of carbohydrates as starting materials for the synthesis of antimicrobial agents is explored. The most recent and successful reports of sugar‐based bactericides, bacteriostatic agents, and adhesin binders are covered with focus on the methodologies employed in their synthesis, resulting in a useful compilation of state‐of ...
Ana Marta de Matos
wiley   +1 more source

Novel molecules and target genes for vegetative heat tolerance in wheat

Plant-Environment Interactions, Volume 3, Issue 6, Page 264-289, December 2022., 2022
Chronic heat stress induces distinct physiological, metabolomic, and transcriptomic changes in a heat‐tolerant Triticum aestivum cultivar, Cadenza, compared to a susceptible cultivar, Paragon. Previously uncharacterized metabolites and genes are differentially regulated in the heat‐tolerant cultivar, providing potential for future crop heat tolerance ...
Teresa Rose, Mark Wilkinson, Claudia Lowe, Jiemeng Xu, David Hughes, Kirsty L. Hassall, Keywan Hassani‐Pak, Sandeep Amberkar, Clarice Noleto‐Dias, Jane Ward, Sigrid Heuer   +10 more
wiley   +1 more source

OGG1 contributes to hepatocellular carcinoma by promoting cell cycle‐related protein expression and enhancing DNA oxidative damage repair in tumor cells

Journal of Clinical Laboratory Analysis, Volume 36, Issue 7, July 2022., 2022
Figure 1 Expression of OGG1 in HCC, (A) expression of OGG1 in nucleoplasma, (B, C) OGG1 expression in healthy liver tissues, (D, E, F) OGG1 expression in liver tissues of HCC patients (G) expression of OGG1 in HCC based on sample type (H) nodal metastasis status (I) TP53 mutation status (J) age (K) gender (L) race (M) stage (N) grade (O) histological ...
He Zhang, Peng‐jun Jiang, Meng‐yuan Lv, Yan‐hua Zhao, Ju Cui, Jie Chen   +5 more
wiley   +1 more source

Pharmacomicrobiomics: Influence of gut microbiota on drug and xenobiotic metabolism

The FASEB Journal, Volume 36, Issue 6, June 2022., 2022
Abstract Gut microbiota is the most diverse and complex biological ecosystem, which is estimated to consist of greater than 5 million distinct genes and 100 trillion cells which are in constant communication with the host environment. The interaction between the gut microbiota and drugs and other xenobiotic compounds is bidirectional, quite complicated,
Ifeoma Julieth Dikeocha, Abdelkodose Mohammed Al‐Kabsi, Muhammad Miftahussurur, Mohammed Abdullah Alshawsh   +3 more
wiley   +1 more source

Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants

Angewandte Chemie, Volume 132, Issue 30, Page 12599-12605, July 20, 2020., 2020
One mutant, six targets: The regio‐ and stereoselective C−H activation for hydroxylation of six different steroids with formation of C7β alcohols was accomplished using a single P450 mutant evolved by protein library construction based on a special DNA assembly and cloning procedure.
Aitao Li, Carlos G. Acevedo‐Rocha, Lorenzo D'Amore, Jinfeng Chen, Yaqin Peng, Marc Garcia‐Borràs, Chenghua Gao, Jinmei Zhu, Harry Rickerby, Sílvia Osuna, Jiahai Zhou, Manfred T. Reetz   +11 more
wiley   +2 more sources

Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy. [PDF]

Chempluschem
Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Hilber S, Attionu SK, Dayie TK, Kreutz C.   +3 more
europepmc   +2 more sources

Adaptive evolution of drug targets in producer and non-producer organisms [PDF]

, 2012
Mycophenolic acid (MPA) is an immunosuppressive drug produced by several fungi in Penicillium subgenus Penicillium. This toxic metabolite is an inhibitor of IMP dehydrogenase (IMPDH). The MPA biosynthetic cluster of P.
Balzarini, Bentley, Bjarne G. Hansen, Chooi, Christian S. Kaas, Collart, Farazi, Frisvad, Frisvad, Gao, Geu-Flores, Hansen, Hansen, Hans J. Genee, Hartman, Hedstrom, Hoff, Jakob B. Nielsen, Jenks, Jens C. Frisvad, Khersonsky, Kohler, Kohler, Lightfoot, Link, Lizbeth Hedstrom, MacPherson, Nimmesgern, Norholm, O'Brien, Regueira, Saitou, Sintchak, Tracewell, Uffe H. Mortensen, van den Berg, Wang, Wilson, Wilson, Wu, Xin E. Sun   +40 more
core   +1 more source

A family of thermostable fungal cellulases created by structure-guided recombination [PDF]

, 2009
SCHEMA structure-guided recombination of 3 fungal class II cellobiohydrolases (CBH II cellulases) has yielded a collection of highly thermostable CBH II chimeras.
A. Villalobos, C. D. Snow, C. Nguyen, F. H. Arnold, Go, Godbole, Hui, I. Wu, Innis, J. Minshull, Jeoh, Koivula, Li, Liu, Lussier, Nelson, Otey, P. Heinzelman, S. Govindarajan, Sch  lein   +19 more
core   +3 more sources