RNA structural probing of guanine and uracil nucleotides in yeast. [PDF]
PLoS ONE, 2023 RNA structure can be essential for its cellular function. Therefore, methods to investigate the structure of RNA in vivo are of great importance for understanding the role of cellular RNAs.
Kevin Xiao +2 more
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The nucleobase analog 4-thiouracil hijacks the pyrimidine salvage pathway to inhibit Staphylococcus aureus growth [PDF]
Microbiology SpectrumStaphylococcus aureus is a leading cause of bacterial-induced mortality due to infections that are increasingly resistant to antibiotics, highlighting the need for new therapeutic strategies to treat these drug-resistant infections.
Matthew J. Munneke +2 more
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UDP-glucose and MRS2905 agonist-bound states of the purinergic P2Y14 receptor [PDF]
Communications BiologyP2Y14 receptors respond to uracil-diphosphate-hexose conjugates, yet how this receptor selectively recognizes both uracil-nucleotides and hexose moieties of diverse agonists remains unclear.
Jonathan F. Fay +10 more
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Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. [PDF]
J Pharmacol Exp Ther, 2013 The orphan receptor GPR17 has been reported to be activated by UDP, UDP-sugars, and cysteinyl leukotrienes, and coupled to intracellular Ca2+ mobilization and inhibition of cAMP accumulation, but other studies have reported either a different agonist profile or lack of agonist activity altogether.
Qi AD, Harden TK, Nicholas RA.
europepmc +4 more sources
The relationship between gene traits and transcription in soil microbial communities varies by environmental stimulus [PDF]
PeerJCodon and nucleotide frequencies are known to relate to the rate of gene transcription, yet how these traits shape transcriptional profiles of soil microbial communities remains unclear.
Peter F. Chuckran +5 more
doaj +3 more sources
The Role of Metabolites in CSF on NAFLD Development: A Mendelian Randomisation Analysis [PDF]
Endocrinology, Diabetes & MetabolismBackground Non‐alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition linked to metabolic syndrome. Recent studies suggest that metabolites in cerebrospinal fluid (CSF) may play a role in NAFLD development; however, the specific ...
Fang Liang, Tiegang Xiao, Bing Wang
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UdgX-Mediated Uracil Sequencing at Single-Nucleotide Resolution [PDF]
Journal of the American Chemical Society, 2022 As an aberrant base in DNA, uracil is generated by either deoxyuridine (dU) misincorporation or cytosine deamination, and involved in multiple physiological and pathological processes. Genome-wide profiles of uracil are important for study of these processes.
Liudan Jiang +19 more
openaire +4 more sources
BioTechniques, 2022 This study sought to develop a short DNA detection method using a deoxyuridine probe and polymerase chain reaction. The probe was hybridized to the target short DNA, which was then extended by DNA polymerase.
Naoki Harikai +4 more
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On the prebiotic selection of nucleotide anomers: A computational study
Heliyon, 2022 Present-day known predominance of the β- over the α-anomers in nucleosides and nucleotides emerges from a thermodynamic analysis of their assembly from their components, i.e. bases, sugars, and a phosphate group.
Lázaro A.M. Castanedo, Chérif F. Matta
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Biochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2013 Uracil phosphoribosyltransferase (UPRT) catalyzes the conversion of uracil and 5-phosphoribosyl-α-1-pyrophosphate (PRPP) to uridine 5'-monophosphate (UMP) and pyrophosphate (PP(i)). UPRT plays an important role in the pyrimidine salvage pathway since UMP
Anne Drumond Villela +8 more
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