The relationship between gene traits and transcription in soil microbial communities varies by environmental stimulus [PDF]
PeerJCodon and nucleotide frequencies are known to relate to the rate of gene transcription, yet how these traits shape transcriptional profiles of soil microbial communities remains unclear.
Peter F. Chuckran +5 more
doaj +2 more sources
Rational Design Strategies for Stimuli‐Responsive DNAzymes Using Modified and Artificial Nucleotides
Chemistry – A European Journal, EarlyView.Activity control of RNA‐cleaving DNAzymes in response to external stimuli has attracted growing interest for applications in DNA‐based diagnostics, therapeutics, and dynamic DNA nanotechnology. This review summarizes rational design strategies for stimuli‐responsive DNAzymes using modified or artificial nucleotides, including split and caged DNAzymes ...
Yusuke Takezawa, Mitsuhiko Shionoya
wiley +1 more source
Identification of novel genes regulating the development of the palate
Developmental Dynamics, EarlyView.Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley +1 more source
Exploring the Fate of Nitrogen Heterocycles in Complex Prebiotic Mixtures [PDF]
, 2011 A long standing question in the field of prebiotic chemistry is the origin of the genetic macromolecules DNA and RNA. DNA and RNA have very complex structures with repeating subunits of nucleotides, which are composed of nucleobases (nitrogen ...
Callahan, Michael P. +4 more
core +1 more source
Biosynthetic potentials of metabolites and their hierarchical organization [PDF]
, 2008 Peer reviewedPublisher ...
Ebenhoeh, Oliver +2 more
core +4 more sources
Environmental and Molecular Mutagenesis, EarlyView.Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk +4 more
wiley +1 more source
Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker. [PDF]
, 2011 Most bacteria can only be transformed with circular plasmids, so robust DNA integration methods for these rely upon selection of single-crossover clones followed by counter-selection of double-crossover clones.
Cartman, ST +6 more
core +5 more sources
Food Safety and Health, EarlyView.This picture illustrates a novel aptamer‐based colorimetric assay, which demonstrates that high sensitivity, selectivity, and reliability for the rapid detection of cadmium ions (Cd2+) in water. Molecular dynamics (MD) simulations have revealed that the complexes are more stable, with Cd2+ binding more tightly to the thymine (T) within the aptamer loop.
Xuyan Li +7 more
wiley +1 more source
Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. [PDF]
, 2016 RNA polymerase II (pol II) utilizes a complex interaction network to select and incorporate correct nucleoside triphosphate (NTP) substrates with high efficiency and fidelity.
Chong, Jenny +10 more
core +3 more sources
Complete genome sequence of Mycoplasma suis and insights into its biology and adaption to an erythrocyte niche. [PDF]
PLoS ONE, 2011 Mycoplasma suis, the causative agent of porcine infectious anemia, has never been cultured in vitro and mechanisms by which it causes disease are poorly understood. Thus, the objective herein was to use whole genome sequencing and analysis of M.
Ana M S Guimaraes +5 more
doaj +1 more source