Results 111 to 120 of about 22,593 (200)

Rex1p Deficiency Leads to Accumulation of Precursor Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e and Polyadenylation of Substrate RNAs in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]

, 2009
A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme subunit, was combined with the deletion of any non-essential gene in Saccharomyces cerevisiae.
Anderson, James T., Boone, Charles, Brost, Renee L., Costanzo, Michael, Ozanick, Sarah G., Wang, Xuying   +5 more
core   +1 more source

p-Adic Modelling of the Genome and the Genetic Code

, 2007
The present paper is devoted to foundations of p-adic modelling in genomics. Considering nucleotides, codons, DNA and RNA sequences, amino acids, and proteins as information systems, we have formulated the corresponding p-adic formalisms for their ...
Dragovich, Alexandra, Dragovich, Branko
core   +1 more source

BRCA1 Promoter Methylation in Ovarian Cancer: Clinical Relevance and a Novel Diagnostic Approach Using Fragment Analysis

Cancer Science, EarlyView.
With the aim of clinical applications, we established a simplified evaluation method for BRCA1 methylation using fragment analysis, called BRCA1‐FAM. We confirmed that high‐grade serous ovarian cancer patients with BRCA1 methylation had poor prognosis.
Saki Tsuchimochi, Yoko Yamamoto, Ayumi Taguchi, Masahito Kawazu, Kenbun Sone, Masako Ikemura, Kana Tamai, Shuhei Kitamura, Daisuke Yoshimoto, Sayuri Fukaya, Aya Ishizaka, Anh Duong Quynh, Akira Nishijima, Yuichiro Miyamoto, Mayuyo Mori, Osamu Hiraike, Kosei Hasegawa, Tetsuo Ushiku, Katsutoshi Oda, Yasushi Hirota, Yutaka Osuga   +20 more
wiley   +1 more source

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

Descripción del ARN de transferencia mitocondrial para Serina (UCN) de Lutzomyia columbiana (Diptera, Psychodidae) Description of the mitochondrial serine transfer RNA (UCN) of Lutzomyia columbiana (Diptera, Psychodidae)

Revista Brasileira de Entomologia, 2008
Lutzomyia columbiana es un flebotomíneo considerado como vector sospechoso de Leishmania mexicana y Leishmania braziliensis en Colombia. Este insecto pertenece al grupo verrucarum, que incluye algunos taxones isomórficos, lo que ha estimulado la búsqueda
Alveiro Pérez-Doria, Eduar Elías Bejarano, Iván Darío Vélez   +2 more
doaj   +1 more source

Accuracy of Metabolomics in Peri‐Implant Crevicular Fluid for Diagnosis and Prognosis of Peri‐Implantitis

Journal of Periodontal Research, EarlyView.
Define metabolites diagnostic of peri‐implantitis and predictive of future radiographic bone‐level (RBL) destruction. Metabolomics via Proton‐Nuclear Magnetic Resonance Spectroscopy of peri‐implant crevicular fluid. Cadaverine/Lysine and Putrescine signatures predict peri‐implantitis, while alpha‐ketoglutarate diagnoses implant health.
Hatem Alassy, Elias Kersten, Janelle Hamilton, Barbara Botorous, Angelomaria Iuorio, Todd Rappe, Massimo Costalonga   +6 more
wiley   +1 more source

A proton magnetic resonance investigation of the glycosyl torsion angle of uracil nucleosides and nucleotides

Nucleic Acids Research, 1975
The use of line-shape decomposition techniques permitted the small 5-bond (5-J51') and 4-bond (4-J61') proton-proton coupling constants of a series of uracil nucleosides and nucleotides to be determined accurately. From an analysis of these coupling constants we have determined that the uracil base is in a predominantly anti conformation in aqueous ...
Bradford P. Cross, Thomas Schleich, Ted R. Lusebrink, Neil Johnson   +3 more
openaire   +4 more sources

Identification of EppR, a Second Repressor of Error‐Prone DNA Polymerase Genes in Acinetobacter baumannii

Molecular Microbiology, EarlyView.
A novel TetR‐like regulator (EppR) has been identified to repress genes encoding DNA polymerase V in Acinetobacter baumannii through the direct binding of a conserved EppR motif in their promoters. EppR works with previously identified regulator UmuDAb to serve as co‐regulators of these genes. In response to DNA damage and/or environmental stress, both
Brian Nguyen, Carly Ching, Ashley MacGuire, Pranav Casula, Connor Newman, Faith Finley, Veronica G. Godoy   +6 more
wiley   +1 more source

How to measure the probability of uracil chain tautomers as nucleotide bases in RNA?

Journal of Biomolecular Structure and Dynamics
The current research focuses on exploring tautomerism in uracil. 47 tautomers were found that varied in significance in RNA and stability. To discover these molecules, diverse potential energy levels were explored, and corresponding transition states were found in these pathways.
Parisa Fereidounpour, Shapour Ramazani
openaire   +1 more source

Exploring the untapped potential of single‐cell and spatial omics in plant biology

New Phytologist, EarlyView.
Summary Advances in single‐cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells and their spatial organization within tissues. The field of plant biology has widely adopted single‐cell transcriptome and chromatin accessibility profiling and spatial transcriptomics, which extend ...
Tatsuya Nobori
wiley   +1 more source