Results 31 to 40 of about 22,593 (200)

Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions [PDF]

, 2010
Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions.
A Fujimori, A Mizutani, A Niimi, A Saberi, A Tissier, Akira Motegi, Alan Lehmann, AR Lehmann, AR Lehmann, BS Plosky, C Guo, C Guo, C Masutani, C Masutani, Chikahide Masutani, CW Lawrence, D Szuts, Dávid Szüts, E Sonoda, E Sonoda, E Sonoda, EC Friedberg, EC Friedberg, Eiichiro Sonoda, Fumio Hanaoka, H Arakawa, H Arakawa, H Hochegger, HL Waters, J Akagi, James E. Haber, JE Sale, JE Sale, JH Yoon, JH Yoon, JM Di Noia, Julian E. Sale, K Bebenek, K Nojima, K Takenaka, K Watanabe, Kouji Hirota, M Bienko, M Takata, M Yamazoe, MR Albertella, MS Yuasa, MT Washington, O Ziv, PL Kannouche, PP Van Sloun, R Kusumoto, R Shinkura, R Woodgate, RE Johnson, RE Johnson, RE Johnson, RS Harris, S Prakash, S Shachar, SD McCulloch, Shigenori Iwai, Shunichi Takeda, T Kawamoto, T Okada, Takuo Kawamoto, WT Wolfle, X Wu, Y Murakumo, YC Wang, YM Yamashita   +70 more
core   +10 more sources

Tools and drugs for uracil nucleotide-activated P2Y receptors

Pharmacology & Therapeutics, 2018
P2Y receptors (P2YRs) are a family of G protein-coupled receptors activated by extracellular nucleotides. Physiological P2YR agonists include purine and pyrimidine nucleoside di- and triphosphates, such as ATP, ADP, UTP, UDP, nucleotide sugars, and dinucleotides.
Rafehi, Muhammad, Müller, Christa E.
openaire   +5 more sources

Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress [PDF]

Biochemical Pharmacology, 2005
Cardiomyocytes express one or more subtypes of P2 receptors for extracellular nucleotides. P2 purinoceptors, which are activated by nucleotides, are classified as P2X or P2Y: P2X receptors are ligand-gated intrinsic ion channels, and P2Y receptors are G protein-coupled receptors.
Asher Shainberg, Smadar Yitzhaki, Vladimir Shneyvays, Kenneth A. Jacobson   +3 more
openaire   +3 more sources

Northern Blot of tRNA in Yeast

Bio-Protocol, 2013
tRNAs are small RNAs around 70-90 nt. tRNAs are different from many other small RNAs in that they are very abundant, which makes it difficult to study their transcriptional regulation by traditional northern blot.
Yuehua Wei
doaj   +1 more source

Road blocks on paleogenomes - polymerase extension profiling reveals the frequency of blocking lesions in ancient DNA [PDF]

, 2010
Although the last few years have seen great progress in DNA sequence retrieval from fossil specimens, some of the characteristics of ancient DNA remain poorly understood. This is particularly true for blocking lesions, i.e.
Briggs, A., Heyn, P., Hofreiter, M., Kircher, M., Meyer, M., Stenzel, U.   +5 more
core   +2 more sources

On the prebiotic selection of nucleotide anomers: A computational study

Heliyon, 2022
Present-day known predominance of the β- over the α-anomers in nucleosides and nucleotides emerges from a thermodynamic analysis of their assembly from their components, i.e. bases, sugars, and a phosphate group.
Lázaro A.M. Castanedo, Chérif F. Matta
doaj  

Catalytic mechanism of alpha-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling. [PDF]

, 2013
Enzymatic synthesis and hydrolysis of nucleoside phosphate compounds play a key role in various biological pathways, like signal transduction, DNA synthesis and metabolism.
Aherne, Ali, Amyes, Andrea Bodor, András Perczel, Barabas, Barabas, Barabas, Batra, Baxter, Becke, Beáta G. Vértessy, Brunger, Castillo-Acosta, CCP4, Cedergren-Zeppezauer, Chan, Cherepanov, Dauter, DeLano, Dubrovay, Edina Rosta, Emsley, Fiser, Florian, Freeman, Friesner, Galperin, Garcia-Nafria, Garcia-Nafria, García-Nafría, Gerlt, Glowacki, Gonen, Hampton, Horvati, Imre Zagyva, Ivanov, Jiang, Jones, Kabsch, Kamerlin, Kamerlin, Klahn, Kovari, Lahiri, Lamzin, Lari, Larsson, Larsson, Leiros, Leslie, Matthias Wilmanns, Merenyi, Mildvan, Miyahara, Miyahara, Moffat, Mol, Muha, Nagel, Nakamura, Nemeth-Pongracz, Nicholas, Nord, Nord, Nord, Nowotny, Orsolya Barabás, Pauling, Pecsi, Pecsi, Pecsi, Persson, Persson, Prasad, Prasad, Quesada-Soriano, Ramon-Maiques, Rosta, Rosta, Terwilliger, Toth, Van Calenbergh, Varga, Varga, Veronika Németh, Vertessy, Vertessy, Vertessy, Vertessy, Vertessy, Vince I. Grolmusz, Whittingham, Wilson, Wilson, Winn, Wolfenden, Woodcock, Xu, Zoltán Kele, Zoltán Szabadka   +101 more
core   +2 more sources

Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice

Virology Journal, 2008
Background Low levels of uracil in DNA result from misincorporation of dUMP or cytosine deamination. Vaccinia virus (VACV), the prototype poxvirus, encodes two enzymes that can potentially reduce the amount of uracil in DNA.
Moss Bernard, De Silva Frank S
doaj   +1 more source

Metabolome analysis of genus Forsythia related constituents in Forsythia suspensa leaves and fruits using UPLC-ESI-QQQ-MS/MS technique.

PLoS ONE, 2022
Forsythia suspensa is a traditional Chinese herb. Its numerous metabolites have important roles, as they possessed a wide range of biological activities. This study explored the accumulations of F.
Lingdi Liu, Yu Sun, Chunxiu Wen, Tao Jiang, Wei Tian, Xiaoliang Xie, Xusheng Cui, Ruike Lu, Jiaxing Feng, Aihong Jin, Saiqun Wen, Wei Wei   +11 more
doaj   +1 more source

Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings

Frontiers in Plant Science, 2023
In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination.
Robert D. Slocum, Carolina Mejia Peña, Zhongchi Liu   +2 more
doaj   +1 more source