Results 41 to 50 of about 601,747 (289)

DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA. [PDF]

, 2017
Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat ...
Guo, Huatao, Han, Jin, Heng, Xiao, Lee, William R, Miller, Jeff F, Naorem, Santa S, Wang, Shufang   +6 more
core   +3 more sources

Interplay Between Capsule Expression and Uracil Metabolism in Streptococcus pneumoniae D39

Frontiers in Microbiology, 2018
Pyrimidine nucleotides play an important role in the biosynthesis of activated nucleotide sugars (NDP-sugars). NDP-sugars are the precursors of structural polysaccharides in bacteria, including capsule, which is a major virulence factor of the human ...
Sandra M. Carvalho, Tomas G. Kloosterman, Irfan Manzoor, José Caldas, Susana Vinga, Jan Martinussen, Lígia M. Saraiva, Oscar P. Kuipers, Ana R. Neves   +8 more
doaj   +1 more source

Effects of different temperatures and diets on nutritional and bio‐functional components in the juvenile lined seahorse (Hippocampus erectus)

Journal of the World Aquaculture Society, 2023
A two‐factorial experiment (temperature with three levels: 23°C, 25.5°C and 28°C; diet with four kinds: live Artemia sp., copepods, live Artemia sp. + copepods and frozen Neomysis awatschensis [FNA]) was carried out to evaluate the effects of different ...
Xin Liu, Xueling Li, Dong Zhang, Tingting Lin, Siping Li   +4 more
doaj   +1 more source

Structure Characterization of Escherichia coli Pseudouridine Kinase PsuK

Frontiers in Microbiology, 2022
Pseudouridine (Ψ) is one of the most abundant RNA modifications in cellular RNAs that post-transcriptionally impact many aspects of RNA. However, the metabolic fate of modified RNA nucleotides has long been a question. A pseudouridine kinase (PsuK) and a
Xiaojia Li, Xiaojia Li, Kangjie Li, Wenting Guo, Yan Wen, Yan Wen, Chunyan Meng, Baixing Wu   +7 more
doaj   +1 more source

Nonsynonymous Mutations in Linker-2 of the Pdr5 Multidrug Transporter Identify a New RNA Stability Element

G3: Genes, Genomes, Genetics, 2020
Analysis of synonymous mutations established that although the primary amino acid sequence remains unchanged, alterations in transcription and translation can result in significant phenotypic consequences. We report the novel observation that a series of
Hadiar Rahman, Andrew Rudrow, Joshua Carneglia, Sister Stephen Patrick Joly, Dante Nicotera, Michael Naldrett, John Choy, Suresh V. Ambudkar, John Golin   +8 more
doaj   +1 more source

Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases

Nature Communications, 2023
Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive.
Chia-Shin Yang, Tzu-Ping Ko, Chao-Jung Chen, Mei-Hui Hou, Yu-Chuan Wang, Yeh Chen   +5 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]

, 2020
Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu, Komor, Alexis C, Rallapalli, Kartik Lakshmi   +2 more
core   +2 more sources

The Mechanism of Dna Repair by Uracil-Dna Glycosylase: Studies Using Nucleotide Analogues [PDF]

Nucleosides, Nucleotides and Nucleic Acids, 2000
2',4'-Dideoxy-4'-methyleneuridine incorporated into oligodeoxynucleotides forms regular B-DNA duplexes as shown by Tm and CD measurements. Such oligomers are not cleaved by the DNA repair enzyme, UDG, which cleaves the glycosylic bond in dU but not in dT nor in dC nucleosides in single stranded and double stranded DNA. Differential binding of oligomers
Angelika Rösler, George Panayotou, D. Hornby, Tom Barlow, Tom Brown, Laurence H. Pearl, Renos Savva, G. Michael Blackburn   +7 more
openalex   +3 more sources

Expression of microRNAs in Horse Plasma and Their Characteristic Nucleotide Composition. [PDF]

PLoS ONE, 2016
MicroRNAs (miRNAs) in blood plasma are stable under high levels of ribonuclease activity and could function in tissue-to-tissue communication, suggesting that they may have distinctive structural characteristics compared with non-circulating miRNAs.
Seungwoo Lee, Seungwoo Hwang, Hee Jeong Yu, Dayoung Oh, Yu Jung Choi, Myung-Chul Kim, Yongbaek Kim, Doug-Young Ryu   +7 more
doaj   +1 more source