Results 51 to 60 of about 601,747 (289)

Reduced methionine synthase expression results in uracil accumulation in mitochondrial DNA and impaired oxidative capacity

PNAS Nexus, 2023
Adequate thymidylate [deoxythymidine monophosphate (dTMP) or the “T” base in DNA] levels are essential for stability of mitochondrial DNA (mtDNA) and nuclear DNA (nDNA).
Katarina E. Heyden, J. Fiddler, Yuwen Xiu, O. Malysheva, Michal K. Handzlik, Whitney N. Phinney, L. Stiles, S. Stabler, Christian M. Metallo, M. Caudill, M. Field   +10 more
semanticscholar   +1 more source

High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells

Molecular Therapy: Nucleic Acids, 2022
Precise genome editing of human pluripotent stem cells (hPSCs) is crucial not only for basic science but also for biomedical applications such as ex vivo stem cell therapy and genetic disease modeling.
Ju-Chan Park, Hyeon-Ki Jang, Jumee Kim, Jun Hee Han, Youngri Jung, Keuntae Kim, Sangsu Bae, Hyuk-Jin Cha   +7 more
doaj   +1 more source

The epitranscriptome in stem cell biology and neural development

Neurobiology of Disease, 2020
The blossoming field of epitranscriptomics has recently garnered attention across many fields by findings that chemical modifications on RNA have immense biological consequences.
Caroline Vissers, Aniketa Sinha, Guo-li Ming, Hongjun Song   +3 more
doaj   +1 more source

Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms [PDF]

, 2013
<p>Background: African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.</p> <p>Methodology/Principal ...
A Hofer, Anne Donachie, B Aronow, B Rodenko, BA Fox, Ben L. Kelly, CC Wang, D Bi, Daniel N. A. Tagoe, DB Longley, DJ Hammond, ET Larson, G Gao, G Priotto, H Hirumi, Harry P. de Koning, HF Hassan, HMS Ibrahim, HP De Koning, HP De Koning, HP De Koning, HP De Koning, HP De Koning, HP De Koning, IG Papageorgiou, JA Ali, Jane C. Munday, JB French, Juma A. M. Ali, K Van Dyke, KL Martin, Liam J. Morrison, LJ Wallace, M Balasegaram, M Berg, M Berg, MD Scahill, MI Al-Salabi, MJ Natto, MK Gould, N Sienkiewicz, N Sternberg, PI Fields, R Brun, R Brun, S Gudin, S Lillico, SM Landfear, TL Arakaki, V Bellofatto, VM Castillo-Acosta, ZN Wilson   +51 more
core   +4 more sources

Tools and drugs for uracil nucleotide-activated P2Y receptors

Pharmacology & Therapeutics, 2018
P2Y receptors (P2YRs) are a family of G protein-coupled receptors activated by extracellular nucleotides. Physiological P2YR agonists include purine and pyrimidine nucleoside di- and triphosphates, such as ATP, ADP, UTP, UDP, nucleotide sugars, and dinucleotides.
Rafehi, Muhammad, Müller, Christa E.
openaire   +4 more sources

Northern Blot of tRNA in Yeast

Bio-Protocol, 2013
tRNAs are small RNAs around 70-90 nt. tRNAs are different from many other small RNAs in that they are very abundant, which makes it difficult to study their transcriptional regulation by traditional northern blot.
Yuehua Wei
doaj   +1 more source

Genomic organization of nucleolin gene in carp fish: Evidence for several genes [PDF]

, 2006
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000200017&lng=es&nrm=isoThe protein nucleolin, functionally involved in the main steps of ribosome biogenesis, is codified by a single copy gene in mammals.
Alvarez, Marco, Molina, Alfredo, Navarro, Cristina, Quezada, Claudia, San Martín, Rody, Vera, Ines   +5 more
core   +2 more sources

Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]

, 2020
The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T., Kaspar, Felix, Klare, Hendrik F. T., Kurreck, Jens, Neubauer, Peter, Paulick, Katharina, Röhrs, Viola, Wagner, Anke, Westarp, Sarah, Yehia, Heba   +9 more
core   +1 more source

Metabolome analysis of genus Forsythia related constituents in Forsythia suspensa leaves and fruits using UPLC-ESI-QQQ-MS/MS technique.

PLoS ONE, 2022
Forsythia suspensa is a traditional Chinese herb. Its numerous metabolites have important roles, as they possessed a wide range of biological activities. This study explored the accumulations of F.
Lingdi Liu, Yu Sun, Chunxiu Wen, Tao Jiang, Wei Tian, Xiaoliang Xie, Xusheng Cui, Ruike Lu, Jiaxing Feng, Aihong Jin, Saiqun Wen, Wei Wei   +11 more
doaj   +1 more source

dUTPase based switch controls transfer of virulence genes in order to preserve integrity of the transferred mobile genetic elements [PDF]

, 2013
dUTPases ubiquitously regulate cellular dUTP levels to preserve genome integrity. Recently, several other cellular processes were reported to be controlled by dUTPases including the horizontal transfer of Staphylococcus aureus pathogenicity islands ...
Bendes, A., Besztercei, B., Leveles, I., Liliom, K., Nyíri, K., Németh-Pongrácz, V., Papp-Kádár, V., Pálinkás, H., Róna, G., Szabó, J. E., Tóth, J., Vértessy G., Beáta, Zagyva, I.   +12 more
core   +1 more source