Results 61 to 70 of about 601,747 (289)

Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase [PDF]

, 2013
Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis.
A. R. Cole, Acharya, Barrett, Berkner, Broennimann, dos Reis, Duncan, Emsley, Freitag, G. Baltulionis, Haushalter, Hennessy, Huang, Jern, K. Ryzhenkova, Kabsch, Katz, Kiljunen, Kleywegt, Koulis, Martomo, McCoy, Newman, P. Hornyak, Pearl, Perez-Lago, Putnam, Putnam, R. Savva, S. Ofer, Savva, Savva, Savva, Schorman, Sharp, Takahashi, Tye, Warner, Warren, Winn   +39 more
core   +1 more source

Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice

Virology Journal, 2008
Background Low levels of uracil in DNA result from misincorporation of dUMP or cytosine deamination. Vaccinia virus (VACV), the prototype poxvirus, encodes two enzymes that can potentially reduce the amount of uracil in DNA.
Moss Bernard, De Silva Frank S
doaj   +1 more source

Transcriptional reprogramming of nucleotide metabolism in response to altered pyrimidine availability in Arabidopsis seedlings

Frontiers in Plant Science, 2023
In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in pyrimidine starvation and developmental arrest a few days after germination.
Robert D. Slocum, Carolina Mejia Peña, Zhongchi Liu   +2 more
doaj   +1 more source

Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation [PDF]

, 2007
Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and other class I G protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis ...
Kim, Soo-Kyung, Li, Bo, Scarselli, Marco, Wess, Jürgen   +3 more
core   +1 more source

Molecular characterization of the virulent infectious hematopoietic necrosis virus (IHNV) strain 220-90

Virology Journal, 2010
Background Infectious hematopoietic necrosis virus (IHNV) is the type species of the genus Novirhabdovirus, within the family Rhabdoviridae, infecting several species of wild and hatchery reared salmonids.
LaPatra Scott E, Ammayappan Arun, Vakharia Vikram N   +2 more
doaj   +1 more source

Raman depolarization ratios in RNA and DNA are sensitive for sugar-base coupling [PDF]

, 1995
Polarized and depolarized Raman spectra are obtained for a number of synthetic polynucleotides containing adenine, uracil, and thymine bases. The depolarization ratios are determined by two methods: (1) by dividing the -spectrum by the -spectrum and (2 ...
Benevides, Brahms, Chandrasekaran, de Mul, Fanconi, Fukushi, Hartman, Kollman, Letellier, Lord, Patapoff, Rao, Saenger, Shelley, Thomas, Tsuboi, Ueda, Wang   +17 more
core   +3 more sources

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

eLife, 2013
Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions, often associated with ...
Benjamin JM Taylor, Serena Nik-Zainal, Yee Ling Wu, Lucy A Stebbings, Keiran Raine, Peter J Campbell, Cristina Rada, Michael R Stratton, Michael S Neuberger   +8 more
doaj   +1 more source

Characterization by Small RNA Sequencing of Taro Bacilliform CH Virus (TaBCHV), a Novel Badnavirus. [PDF]

PLoS ONE, 2015
RNA silencing is an antiviral immunity that regulates gene expression through the production of small RNAs (sRNAs). In this study, deep sequencing of small RNAs was used to identify viruses infecting two taro plants.
Syeda Amber Kazmi, Zuokun Yang, Ni Hong, Guoping Wang, Yanfen Wang   +4 more
doaj   +1 more source

Interaction of low-energy electrons with the purine bases, nucleosides, and nucleotides of DNA [PDF]

, 2006
The authors report results from computational studies of the interaction of low-energy electrons with the purine bases of DNA, adenine and guanine, as well as with the associated nucleosides, deoxyadenosine and deoxyguanosine, and the nucleotide ...
McKoy, Vincent, Winstead, Carl
core   +1 more source

A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs. [PDF]

PLoS ONE, 2011
Dwarfism in German shepherd dogs is due to combined pituitary hormone deficiency of unknown genetic cause. We localized the recessively inherited defect by a genome wide approach to a region on chromosome 9 with a lod score of 9.8.
Annemarie M W Y Voorbij, Frank G van Steenbeek, Manon Vos-Loohuis, Ellen E C P Martens, Jeanette M Hanson-Nilsson, Bernard A van Oost, Hans S Kooistra, Peter A Leegwater   +7 more
doaj   +1 more source