Results 81 to 90 of about 600,907 (304)

Bacteriophage-related epigenetic natural and non-natural pyrimidine nucleotides and their influence on transcription with T7 RNA polymerase

Communications Chemistry
DNA modifications on pyrimidine nucleobases play diverse roles in biology such as protection of bacteriophage DNA from enzymatic cleavage, however, their role in the regulation of transcription is underexplored.
Filip Gracias, Radek Pohl, Veronika Sýkorová, Michal Hocek   +3 more
doaj   +1 more source

Biosynthetic potentials of metabolites and their hierarchical organization [PDF]

, 2008
Peer reviewedPublisher ...
Ebenhoeh, Oliver, Matthaeus, Franziska, Salazar, Carlos   +2 more
core   +4 more sources

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

NMR Metabolomic Analysis of Skeletal Muscle, Heart, and Liver of Hatchling Loggerhead Sea Turtles (Caretta caretta) Experimentally Exposed to Crude Oil and/or Corexit

Metabolites, 2019
We used nuclear magnetic spectroscopy (NMR) to evaluate the metabolic impacts of crude oil, Corexit 5900A, a dispersant, and a crude oil Corexit 5900A mixture exposure on skeletal muscle, heart, and liver physiology of hatchling loggerhead sea turtles ...
Stasia A. Bembenek-Bailey, Jennifer N. Niemuth, Patricia D. McClellan-Green, Matthew H. Godfrey, Craig A. Harms, Hanna Gracz, Michael K. Stoskopf   +6 more
doaj   +1 more source

Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis

BMC Research Notes, 2019
Objective Planarians including Dugesia ryukyuensis (Dr) have strong regenerative abilities that require enhanced DNA replication. Knockdown of the DUT gene in Dr, which encodes deoxyuridine 5′-triphosphate pyrophosphatase (dUTPase), promotes DNA ...
Md. Shahanoor Alam, Hideaki Moriyama, Midori Matsumoto   +2 more
doaj   +1 more source

Exploring the Fate of Nitrogen Heterocycles in Complex Prebiotic Mixtures [PDF]

, 2011
A long standing question in the field of prebiotic chemistry is the origin of the genetic macromolecules DNA and RNA. DNA and RNA have very complex structures with repeating subunits of nucleotides, which are composed of nucleobases (nitrogen ...
Callahan, Michael P., Cleaves, Henderson J., Dworkin, Jason P., House, Christopher H., Smith, Karen E.   +4 more
core   +1 more source

Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity [PDF]

, 2011
The design of synthetic gene networks requires an extensive genetic toolbox to control the activities and levels of protein components to achieve desired cellular functions.
Alper, Alper, Alper, Anderson, Andrew H. Babiskin, Babiskin, Babiskin, Basu, Beisel, Callura, Caponigro, Carrier, Chanfreau, Chanfreau, Chao, Christina D. Smolke, Danin-Kreiselman, Elela, Ellis, Elowitz, Gardner, Ge, Gietz, Hawkins, Hawkins, Isaacs, Jensen, Jin, Jones, Keiler, Lamontagne, Lamontagne, Lamontagne, Lamontagne, Lamontagne, Lamontagne, Larose, Lautz, Lavoie, Lee, Louis, Lutz, Mateus, Misra, Nevoigt, Ng, Nguyen, Ostergaard, Paradise, Pfleger, Ro, Salis, Sambrook, Szczebara, Vasudevan, Veen, Win, Wu, Wu, Zhou, Zhou, Zhu, Zhu   +62 more
core   +3 more sources

Enhanced deoxyviolacein bioproduction via enzyme condensation with a yeast glycolytic enzyme‐derived peptide tag

Biotechnology Progress, EarlyView.
Fusion of a 27‐amino‐acid peptide tag derived from a glycolytic enzyme enabled artificial assembly formation of the two violacein biosynthetic enzymes, VioE and VioC. This assembly resulted in enhanced biosynthesis of deoxyviolacein. Abstract In microbial production, regulating endogenous and exogenous synthetic pathways is essential.
Rioko Ito, Sayoko Ito‐Harashima, Naoko Segawa, Natsuko Miura, Michihiko Kataoka   +4 more
wiley   +1 more source

Capturing the ‘ome’ : the expanding molecular toolbox for RNA and DNA library construction [PDF]

, 2018
All sequencing experiments and most functional genomics screens rely on the generation of libraries to comprehensively capture pools of targeted sequences.
Boone, Morgane, Callewaert, Nico, De Koker, Andries   +2 more
core   +2 more sources

Recent Advances in Chemical Probing Strategies for RNA Structure Determination in Vivo

Chemistry – A European Journal, EarlyView.
This Review illustrates how structural probes combined with advanced sequencing technologies are revolutionizing our ability to map RNA structures and interactions within living cells. It highlights the development of innovative strategies tailored to probe RNA structures in particular biological contexts.
Maryana Yarshova, Jieyu Zhao, Chun Kit Kwok   +2 more
wiley   +1 more source