Results 81 to 90 of about 22,593 (200)

The epitranscriptome in stem cell biology and neural development

Neurobiology of Disease, 2020
The blossoming field of epitranscriptomics has recently garnered attention across many fields by findings that chemical modifications on RNA have immense biological consequences.
Caroline Vissers, Aniketa Sinha, Guo-li Ming, Hongjun Song   +3 more
doaj  

First-principles GW calculations for DNA and RNA nucleobases

, 2011
On the basis of first-principles GW calculations, we study the quasiparticle properties of the guanine, adenine, cytosine, thymine, and uracil DNA and RNA nucleobases.
A. Travers, Carina Faber, Claudio Attaccalite, E. Runge, H. Lodish, V. Olevano, X. Blase   +6 more
core   +4 more sources

The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor [PDF]

The EMBO Journal, 2006
Nucleotides and cysteinyl-leukotrienes (CysLTs) are unrelated signaling molecules inducing multiple effects through separate G-protein-coupled receptors: the P2Y and the CysLT receptors. Here we show that GPR17, a Gi-coupled orphan receptor at intermediate phylogenetic position between P2Y and CysLT receptors, is specifically activated by both families
P. Ciana, M. Fumagalli, M. L. Trincavelli, C. Verderio, P. Rosa, D. Lecca, S. Ferrario, C. Parravicini, V.C. Capra, P. Gelosa, U. Guerrini, S. Belcredito, M. Cimino, L. Sironi, E. Tremoli, G. Rovati, C. Martini, M.P. Abbracchio   +17 more
openaire   +7 more sources

Histochemical indications for a chemically complex signal produced by the cervical gill slit gland of the pygmy sperm whale (Kogia breviceps)

The Anatomical Record, EarlyView.
Abstract The pygmy sperm whale (Kogia breviceps) possesses an exocrine gland associated with its false gill slit pigmentation pattern. The cervical gill slit gland is a compound tubuloalveolar gland that produces a holocrine secretion and displays maturational changes in size and secretory histology. While the morphology of the cervical gill slit gland
Tiffany F. Keenan, William A. McLellan, Sentiel A. Rommel, Alexander M. Costidis, Craig A. Harms, J. G. M. Thewissen, Susan J. Rehorek, David S. Rotstein, Mark D. Gay, Alison R. Taylor, Heather N. Koopman, Ying Wang, Stephanie Kamel, D. Ann Pabst   +13 more
wiley   +1 more source

Exploring the Fate of Nitrogen Heterocycles in Complex Prebiotic Mixtures [PDF]

, 2011
A long standing question in the field of prebiotic chemistry is the origin of the genetic macromolecules DNA and RNA. DNA and RNA have very complex structures with repeating subunits of nucleotides, which are composed of nucleobases (nitrogen ...
Callahan, Michael P., Cleaves, Henderson J., Dworkin, Jason P., House, Christopher H., Smith, Karen E.   +4 more
core   +1 more source

Human Deoxycytidine Kinase Is a Valuable Biocatalyst for the Synthesis of Nucleotide Analogues [PDF]

, 2019
Natural ribonucleoside-5’-monophosphates are building blocks for nucleic acids which are used for a number of purposes, including food additives. Their analogues, additionally, are used in pharmaceutical applications.
Hellendahl, Katja F., Kamel, Sarah, Neubauer, Peter, Wagner, Anke, Wetterwald, Albane   +4 more
core   +1 more source

Responses of the longitudinal muscle and the muscularis mucosae of the rat duodenum to adenine and uracil nucleotides [PDF]

British Journal of Pharmacology, 1996
Previous studies have shown that the rat duodenum contains P1 and P2Y purinoceptors via which it relaxes to adenosine and adenosine 5′‐triphosphate (ATP) respectively. It has also been shown to contract to uridine 5′‐triphosphate (UTP) and adenosine 5′‐O‐(3‐thiotriphosphate) (ATP‐γ‐S), and based on their differential inhibition by the P2 antagonist ...
C. R. Johnson, Steven J. Charlton, Susanna M.O. Hourani   +2 more
openaire   +3 more sources

Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer

BioEssays, EarlyView.
Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, EarlyView.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Increasing Cytosine Base Editing Scope and Efficiency With Engineered Cas9-PmCDA1 Fusions and the Modified sgRNA in Rice

Frontiers in Genetics, 2019
Base editors that do not require double-stranded DNA cleavage or homology-directed repair enable higher efficiency and cleaner substitution of targeted single nucleotides in genomic DNA than conventional approaches.
Ying Wu, Wen Xu, Feipeng Wang, Si Zhao, Feng Feng, Jinling Song, Chengwei Zhang, Jinxiao Yang   +7 more
doaj   +1 more source