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Metabolomics to Identify Unclassified Uremic Toxins: A Comprehensive Literature Review. [PDF]
Kidney MedVanholder R +11 more
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International Urology and Nephrology, 2012
In the last decade, uremic toxicity as a potential cause for the excess of cardiovascular disease and mortality observed in chronic kidney disease gained more and more interest. This review focuses on uremic toxins with known cardiovascular effects and their removal. For protein-bound solutes, for example, indoxylsulfate and the conjugates of p-cresol,
N, Neirynck +5 more
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In the last decade, uremic toxicity as a potential cause for the excess of cardiovascular disease and mortality observed in chronic kidney disease gained more and more interest. This review focuses on uremic toxins with known cardiovascular effects and their removal. For protein-bound solutes, for example, indoxylsulfate and the conjugates of p-cresol,
N, Neirynck +5 more
openaire +2 more sources
Blood Purification, 2013
Nondialyzable uremic toxins can be defined as solutes producing adverse biological effects that consequently to peculiar physicochemical features (mainly their large size and hydrophobic character) cannot leave the blood stream through a dialysis membrane.
PIRODDI, MARTA +3 more
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Nondialyzable uremic toxins can be defined as solutes producing adverse biological effects that consequently to peculiar physicochemical features (mainly their large size and hydrophobic character) cannot leave the blood stream through a dialysis membrane.
PIRODDI, MARTA +3 more
openaire +2 more sources
The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders
Toxins, 2018 Individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing cognitive disorders and dementia. Stroke is also highly prevalent in this population and is associated with a higher risk of neurological deterioration, in ...
Ziad A Massy +2 more
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1987
Aluminum has historically been regarded as non essential, since up to now no physiological function could be ascribed to it. Environmental exposure to aluminum is virtually universal as aluminum constitutes a substantial part of the earth’s crust (8%) and is found in food, medicine and cosmetics.
d' Haese, P.C. +3 more
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Aluminum has historically been regarded as non essential, since up to now no physiological function could be ascribed to it. Environmental exposure to aluminum is virtually universal as aluminum constitutes a substantial part of the earth’s crust (8%) and is found in food, medicine and cosmetics.
d' Haese, P.C. +3 more
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Uremic Toxins and Clinical Outcomes: The Impact of Kidney Transplantation
Toxins, 2018 Non-transplanted and transplanted patients with chronic kidney disease (CKD) differ in terms of mortality and the risk of clinical events. This difference is probably due to the difference of both traditional and non-traditional risk factors.
Sophie Liabeuf, Ziad A Massy
exaly +2 more sources
A Perspective on Uremic Toxins
Archives of Internal Medicine, 1970Even if we could invariably tell them from one another, error and its genesis are no less interesting than correct information, and indeed it is often by way of testable error that we arrive (should we be fortunate) at truth. I make no excuse, therefore, if I dwell for a moment on what may be called the fallacy of misplaced concreteness. I first became
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Journal of Urology, 1998
The author reviews trends and evolution in biochemical methodology, clinical symptomatology description, experimental models and definitions of uremic toxins. The assumption is made of one specific toxic effect for one specific toxin.
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The author reviews trends and evolution in biochemical methodology, clinical symptomatology description, experimental models and definitions of uremic toxins. The assumption is made of one specific toxic effect for one specific toxin.
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Journal of Renal Nutrition, 2008
Hyperphosphatemia is one of the more prevalent metabolic disturbances in kidney failure. Phosphate can be considered a uremic toxin based on the accumulation of phosphate during chronic kidney disease, the effects of phosphate on biological systems, and the adverse effects of hyperphosphatemia. The renal clearance of phosphate is maintained until later
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Hyperphosphatemia is one of the more prevalent metabolic disturbances in kidney failure. Phosphate can be considered a uremic toxin based on the accumulation of phosphate during chronic kidney disease, the effects of phosphate on biological systems, and the adverse effects of hyperphosphatemia. The renal clearance of phosphate is maintained until later
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Journal of Renal Nutrition, 2012
The adipose tissue has pleiotropic functions far beyond the mere storage of energy, and it secretes a number of hormones and cytokines, called adipokines, which have biological effects that impact heath and disease. Adipokines are markedly elevated in the plasma of uremic patients, mainly due to decreased renal excretion.
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The adipose tissue has pleiotropic functions far beyond the mere storage of energy, and it secretes a number of hormones and cytokines, called adipokines, which have biological effects that impact heath and disease. Adipokines are markedly elevated in the plasma of uremic patients, mainly due to decreased renal excretion.
openaire +3 more sources