Results 111 to 120 of about 114,454,660 (263)

Frontiers in transition‐metal single‐atom electrocatalysts: Design tactics, mechanistic regulation, and electrochemical sensing technologies

InfoMat, EarlyView.
This review offers an overview of recent advances in the fundamental properties, synthesis methods, and structural optimization of transition‐metal single‐atom electrocatalysts for electrochemical sensing. It also provides a comprehensive summary of the emerging applications in electrochemical assays based on these materials, along with key challenges ...
Yue Cao, Bo‐Yu Chen, Yiru Sheng, Haoyuan Song, Linan Zhu, Xiaohan Yang, Yuehe Lin, Wenlei Zhu, Yang Zhou   +8 more
wiley   +1 more source

The Urate-Lowering Effects and Renal Protective Activity of Iridoid Glycosides from Paederia foetida in Rats with Hyperuricemia-Induced Kidney Injury: A Pharmacological and Molecular Docking Study

Molecules
(1) Background: The urate-lowering effects of three iridoid glycosides, which are paederosidic acid, paederosidic acid methyl ester, and paederoside, isolated from Paederia foetida and the protection they provide against hyperuricemia-induced kidney ...
Haifeng Zhou, Xinyi Yue, Longhai Shen, Lifeng Wu, Xiaobo Li, Tong Wu   +5 more
doaj   +1 more source

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

Ectopic expression of Aspergillus flavus uricase and URAT1 in therapeutic cells promotes intracellular degradation of uric acid in hyperuricemic mice.

PLoS ONE
Uricase-based drugs excel at treating refractory hyperuricemia and tumor lysis syndrome by directly degrading uric acid but are limited by immunogenicity.
Yuzhong Feng, Jiazhen Cui, Xuan Huang, Yupeng Li, Haolong Dong, Xianghua Xiong, Gang Liu, Qingyang Wang, Huipeng Chen   +8 more
doaj   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Uric Acid and Arterial Stiffness

, 2020
Adriana Albu,1 Ioana Para,2 Mihai Porojan1 12nd Department of Internal Medicine; 24th Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaCorrespondence: Ioana Para 4th Department of ...
Porojan M, Albu A, Para I
core  

The Role and Assessment of Lipid Profile in Patients With a Chronic Total Coronary Occlusion

Lipids, EarlyView.
This review summarized evidence on lipid profiles in CTO patients, non‐CTO patients, and healthy individuals, and examined the reported associations between lipid parameters, collateral channel formation, and clinical outcomes. Several key findings emerged from the present study.
Karol Sadowski, Dominika Tomkiel, Roel Hoek, Ruben W. de Winter, Nick S. Nurmohamed, Bimmer E. P. M. Claessen, Niels J. Verouden, Alexander Nap, Sebastiaan A. Kleijn, Mariusz Tomaniak, Yvemarie B. O. Somsen, Paul Knaapen   +11 more
wiley   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

Fenestrated Microneedle Biosensor for Continuous In Vivo Lactate Monitoring in Interstitial Fluid

Small, EarlyView.
A fenestrated microneedle biosensor enables continuous transdermal monitoring of lactate in interstitial fluid while protecting the functional sensing interface during insertion into the skin. The platform delivers sensitive electrochemical lactate detection and distinguishes metabolic profiles in healthy and type 2 diabetic‐obese mice, and captures ...
Masoud Khazaei, Ali‐Reza Shokouhi, Parham Sahandi Zangabad, Victor J. Cadarso, Muamer Dervisevic, Nicolas H. Voelcker   +5 more
wiley   +1 more source

Chronic-binge ethanol modulates hepatic purine metabolism in mice

Redox Biochemistry and Chemistry
Alcohol-related liver disease (ALD) is a leading cause of chronic liver disease worldwide and is characterized by profound metabolic remodeling. Although purine metabolism is consistently identified as an altered pathway in experimental ALD, the ...
Beatriz Pereira da Silva, Dragana Rajcic, Rodrigo E. Faria-Pesquero, Ester Alves Russo, Priscilla Doria de Mattos, Nícolas Carlos Hoch, Tim Hendrikx, Flavia Carla Meotti   +7 more
doaj   +1 more source