Results 141 to 150 of about 73,683 (226)

Metabolic Dynamics of Central Carbon Pathways in Green‐Lipped Mussels under Heat Stress and Subsequent Recovery

New Zealand Journal of Marine and Freshwater Research, Volume 60, Issue 1, March 2026.
Green‐lipped mussel (Perna canaliculus) aquaculture is vulnerable to environmental changes, which are increasingly being studied to pinpoint physiological, economic and ecological threats. This study utilised a targeted liquid chromatography‐mass spectrometry metabolomics approach, focusing on the central carbon metabolism, to examine the metabolic ...
Leonie Venter, Andrea C. Alfaro, Jeremie Zander Lindeque, Peet J. Jansen van Rensburg, Norman L. C. Ragg, Jessica A. Ericson, Natalí J. Delorme   +6 more
wiley   +1 more source

mRNA-based CAR T cell engineering: Unmodified mRNA enables high CAR expression without innate immune activation in T cells. [PDF]

Mol Ther Nucleic Acids
Kahwaji N, Kotzian N, Prinz JM, Pu Y, Kath J, Picht S, Hiller AL, Klaas A, Dunne CM, Launspach M, Palmowski A, Kleyer A, Simon DN, Wagner DL, Pichon C, Krönke G, Schmueck-Henneresse M, Volk HD, Gossen M, Drzeniek NM.   +19 more
europepmc   +1 more source

Risk Assessment for Drug‐Induced Hyperbilirubinemia: A Mechanistic Approach

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Hyperbilirubinemia, characterized by elevated total blood bilirubin levels including both unconjugated and conjugated forms, serves as a diagnostic marker for drug‐induced liver toxicity associated with a wide range of medications. This study aimed to develop a mechanistic model for assessing hyperbilirubinemia risk using genetic markers.
Rajeev Kumar, Ansu Kumar, Aftab Alam, Yatin Mundkur, James Wingrove   +4 more
wiley   +1 more source

Targeting opportunities presented by the pyrimidine biosynthesis pathway in Mycobacterium tuberculosis: a brief review. [PDF]

Biochem Soc Trans
Alberti M, Miggiano R.
europepmc   +1 more source

THE ENZYMIC INTERCONVERSION OF URIDINE DIPHOSPHOGALACTOSE AND URIDINE DIPHOSPHOGLUCOSE

Journal of Biological Chemistry, 1957
openaire   +2 more sources

Open Systems Pharmacology Community Conference (OSP‐CC) Proceedings 2025

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Developed at Bayer Technology Services, PK‐Sim and MoBi transitioned into the Open Systems Pharmacology (OSP) Suite, released as free open‐source software in 2017. An active community with stakeholders from academia, industries, and regulators contributes to the continuous improvement of open‐source model‐informed drug development (MIDD). This
Henrik Cordes, Pieter Annaert, Pavel Balazki, Salih Benamara, Rodolfo Hernandes Bonan, Andrew Butler, Marylore Chenel, Yunhai Cui, André Dallmann, Wilhelmus E. A. de Witte, Cleo Demeester, Denise Feick, Florence Gattacceca, René Geci, Grégori Gerebtzoff, Andrea Gruber, Mariana Guimarães, Abdullah Hamadeh, Nina Hanke, Manuel Ibarra, Ibrahim Ince, Tobias Kanacher, Lars Kuepfer, Felix Mil, Ghazal Montaseri, Nina Nauwelaerts, Susana Proenca, Stephan Schaller, Jan Frederik Schlender, Annika R. P. Schneider, Erik Sjögren, Juri Solodenko, Alexander Staab, Paul Vrenken, Carla Troisi, Donato Teutonico   +35 more
wiley   +1 more source

Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes. [PDF]

Proc Natl Acad Sci U S A
Chakraborty J, Ghosh A, Awuah EB, Stabler SP, Field MS, Bailey RL, Stover PJ.   +6 more
europepmc   +1 more source

Lock, Protect, and Bind: In Vitro Selection of Locked Nucleic Acid‐Modified Aptamers Using a Mutant T7 RNA Polymerase

Small Structures, Volume 7, Issue 3, March 2026.
We present a novel approach for co‐transcriptional incorporation of locked nucleic acid (LNA) and 2′‐fluoro (2′F) modifications using a mutant T7 RNA polymerase. This method is compatible with in vitro selection and enables efficient, primer‐independent synthesis and amplification of LNA‐modified RNA aptamers with enhanced stability, targeting ...
Kevin Neis, Laia Civit, Kathrine Pedersen, Michael Schachtner, Jesper Wengel, Ralf Wagner, Steffen Thiel, Jørgen Kjems, Julián Valero   +8 more
wiley   +1 more source

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis. [PDF]

Nat Metab
Strefeler A, Baker ZN, Chollet S, Foged MM, Guerra RM, Ivanisevic J, Gallart-Ayala H, Pagliarini DJ, Jourdain AA.   +8 more
europepmc   +1 more source

Emergence, Challenges, and Opportunities for Chiral Nanocellulose Assemblies in Tissue Engineering and Wound Healing

Small Structures, Volume 7, Issue 3, March 2026.
This review explores chiral nanomaterials for tissue engineering and wound healing, specifically focusing on the potential of nanocellulose. The inherent chirality of nanocelluloses and their assemblies enables the creation of biomimetic scaffolds with unique biological interactions. Chiral nematic self‐assembly of cellulose nanocrystals, in particular,
Mahboubeh Nabavinia, Hossein Khanjanzadeh, Asier R. Muguruza, Anna Roig, Erlantz Lizundia, Justin O. Zoppe   +5 more
wiley   +1 more source