Results 1 to 10 of about 8,083 (163)

Cell-Free Multi-Enzyme Synthesis and Purification of Uridine Diphosphate Galactose. [PDF]

Chembiochem, 2022
AbstractHigh costs and low availability of UDP‐galactose hampers the enzymatic synthesis of valuable oligosaccharides such as human milk oligosaccharides. Here, we report the development of a platform for the scalable, biocatalytic synthesis and purification of UDP‐galactose.
Mahour R, Lee JW, Grimpe P, Boecker S, Grote V, Klamt S, Seidel-Morgenstern A, Rexer TFT, Reichl U.   +8 more
europepmc   +5 more sources

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening [PDF]

Molecules, 2019
Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide.
Ohm Prakash, Jana Führing, John Post, Sharon M. Shepherd, Thomas C. Eadsforth, David Gray, Roman Fedorov, Françoise H. Routier   +7 more
doaj   +5 more sources

Uridine diphosphate-glucose 4-epimerase encoding gene galE affects the pathogenicity and carbon metabolism of Ralstonia pseudosolanacearum

浙江大学学报. 农业与生命科学版, 2023
In order to clarify the pathogenic function of uridine diphosphate (UDP)-glucose 4-epimerase encoding gene galE on Ralstonia pseudosolanacearum, the association between galE and the pathogenic-related phenotypes, and the gene deletion effect on ...
ZHANG Hong, LIN Zhijian, ZHU Jindong, LIN Zhaomiao, LI Guoliang, XU Yongqing, LIU Zhonghua, QIU Yongxiang, QIU Sixin   +8 more
doaj   +1 more source

GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction

Platelets, 2023
GALE gene encodes the uridine diphosphate [UDP]-galactose-4-epimerase, which catalyzes the bidirectional interconversion of UDP-glucose to UDP-galactose, and UDP-N-acetyl-glucosamine to UDP-N-acetyl-galactosamine.
Ana Marín-Quílez, Christian A. Di Buduo, Rocío Benito, Alessandra Balduini, José Rivera, Jose Maria Bastida   +5 more
doaj   +1 more source

Carbon source–dependent capsule thickness regulation in Streptococcus pneumoniae

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundThe polysaccharide capsule of Streptococcus pneumoniae plays a major role in virulence, adherence to epithelial cells, and overall survival of the bacterium in the human host.
Joel P. Werren, Joel P. Werren, Nadja Mostacci, Ilche Gjuroski, Lalaina Holivololona, Lukas J. Troxler, Lucy J. Hathaway, Julien Furrer, Markus Hilty   +8 more
doaj   +1 more source

Identification of a carbohydrate recognition motif of purinergic receptors

eLife, 2023
As a major class of biomolecules, carbohydrates play indispensable roles in various biological processes. However, it remains largely unknown how carbohydrates directly modulate important drug targets, such as G-protein coupled receptors (GPCRs).
Lifen Zhao, Fangyu Wei, Xinheng He, Antao Dai, Dehua Yang, Hualiang Jiang, Liuqing Wen, Xi Cheng   +7 more
doaj   +1 more source

SLC35A2-CDG: Novel variant and review

Molecular Genetics and Metabolism Reports, 2021
SLC35A2 encodes the X-linked transporter that carries uridine diphosphate (UDP)-galactose from the cytosol to the lumen of the Golgi apparatus and the endoplasmic reticulum.
Dulce Quelhas, Joana Correia, Jaak Jaeken, Luísa Azevedo, Mónica Lopes-Marques, Anabela Bandeira, Liesbeth Keldermans, Gert Matthijs, Luisa Sturiale, Esmeralda Martins   +9 more
doaj   +1 more source

Generalised uridine diphosphate galactose-4-epimerase deficiency [PDF]

Archives of Disease in Childhood, 1999
The generalised form of epimerase deficiency galactosaemia has been described in only two children from unrelated families. Their progress is reported and three other affected children from these families are described. The initial presentation was similar to classic galactosaemia.
J H, Walter, R E, Roberts, G T, Besley, J E, Wraith, M A, Cleary, J B, Holton, R, MacFaul   +6 more
openaire   +2 more sources

Uridine Diphosphate-4-Keto-Glucose, an Intermediate in the Uridine Diphosphate-Galactose-4-Epimerase Reaction [PDF]

Proceedings of the National Academy of Sciences, 1971
When UDP-galactose 4-epimerase (EC 5.1.3.2) from Escherichia coli is incubated with UDP-galactose, then reduced with NaB 3 H 4 , label is found in UDP-glucose and UDP-galactose.
U S, Maitra, H, Ankel
openaire   +2 more sources

A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]

, 2016
Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I, Kontoravdi, C, Polizzi, K   +2 more
core   +1 more source