Results 31 to 40 of about 3,915 (172)

Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model

Disease Models & Mechanisms, 2014
Classic galactosemia (CG) is an autosomal recessive disorder resulting from loss of galactose-1-phosphate uridyltransferase (GALT), which catalyzes conversion of galactose-1-phosphate and uridine diphosphate (UDP)-glucose to glucose-1-phosphate and UDP ...
Patricia Jumbo-Lucioni, William Parkinson, Kendal Broadie   +2 more
doaj   +1 more source

Uridine Diphosphate Glucose: the Coenzyme of the Galactose–Glucose Phosphate Isomerization [PDF]

Nature, 1950
A PREVIOUS report1 dealt with the enzymatic conversion of galactose-1-phosphate into glucose-1-phosphate and mentioned that a thermostable factor is necessary for the reaction. This factor has now been obtained practically pure, and for reasons given below will be referred to as uridine diphosphate glucose.
Cardini, Carlos E., Paladini, Alejandro C., Caputto, Ranwel, Leloir, Luis Federico   +3 more
openaire   +2 more sources

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Molecules, 2019
Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide.
Ohm Prakash, Jana Führing, John Post, Sharon M. Shepherd, Thomas C. Eadsforth, David Gray, Roman Fedorov, Françoise H. Routier   +7 more
doaj   +1 more source

Do Galactolipid Synthases Play a Key Role in the Biogenesis of Chloroplast Membranes of Higher Plants?

Frontiers in Plant Science, 2018
A unique feature of chloroplasts is their high content of the galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG), which constitute up to 80% of their lipids.
Joana Rocha, Joana Rocha, Milène Nitenberg, Milène Nitenberg, Agnès Girard-Egrot, Juliette Jouhet, Juliette Jouhet, Eric Maréchal, Eric Maréchal, Maryse A. Block, Maryse A. Block, Christelle Breton, Christelle Breton   +12 more
doaj   +1 more source

Studies on the Mechanism of Action of Uridine Diphosphate Galactose 4-Epimerase

Journal of Biological Chemistry, 1973
Timple G. Wee, Perry A. Frey
openalex   +2 more sources

Evolution of milk oligosaccharides and lactose: a hypothesis

Animal, 2012
Mammalian milk or colostrum contains up to 10% of carbohydrate, of which free lactose usually constitutes more than 80%. Lactose is synthesized within lactating mammary glands from uridine diphosphate galactose (UDP-Gal) and glucose by a ...
T. Urashima, K. Fukuda, M. Messer
doaj   +1 more source

Engineering a Robust Escherichia coli W Platform for Scalable Production of Flavonoid-O-Glucosides. [PDF]

Microb Biotechnol
Escherichia coli W demonstrates enhanced flavonoid tolerance while the optimisation of sucrose metabolism in this strain enables efficient chemical glycosylation. Elevated UDP‐glucose production requires both pathway overexpression and removal of native glucose catabolism.
Carranza-Saavedra D, Torres-Bacete J, Bouju E, Nuccio S, Sordon S, Huszcza E, Popłoński J, de Vaumas R, Nogales J.   +8 more
europepmc   +2 more sources

Increased sugar content impairs pollen fertility and reduces seed-setting in high-photosynthetic-efficiency rice

Crop Journal
Crop yield depends on biomass, which is primarily associated with photosynthesis. We previously demonstrated that two photorespiratory bypasses, i.e., GOC (glycolate oxidase + oxalate oxidase + catalase) and GCGT (glycolate oxidase + catalase ...
Bodi Li, Anyao Huang, Limin Wang, Shuofan Wu, Zheng Xu, Xiaoyuan Chen, Zhisheng Zhang, Xinxiang Peng   +7 more
doaj   +1 more source

Deep characterization of refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) and insights into the role of invasive monitoring

Epilepsia, EarlyView.
Abstract Objective Epilepsy surgery is an effective treatment option for patients with medically refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE). The success of surgery depends on the accurate localization of the epileptogenic zone, which can be challenging due to the subtle imaging ...
Jean Khoury, Ingmar Blümcke, Robyn M. Busch, Balu Krishnan, Juan Bulacio, William Bingaman, Demitre Serletis, Imad Najm   +7 more
wiley   +1 more source

Mild Short‐Term Caloric Restriction Induces Coordinated Changes That Promote Lipid Deposition While Maintaining Thermogenesis Capacity in Interscapular Brown Adipose Tissue of Male Rats [PDF]

FASEB J
Rats under mild caloric restriction (85% vs. ad libitum) for 2 weeks show metabolic and structural adaptations in iBAT. Caloric restriction increases glycolysis and triglyceride deposition in the tissue, leading to larger lipid droplets. It also reduces mitochondrial iBAT content, while maintaining iBAT thermogenic potential thanks to an increased ...
Panico G, Migliaccio V, Pinto G, Iliano A, Fasciolo G, Coletta M, Venditti P, Moreno M, Amoresano A, de Lange P, Lionetti L, Lombardi A.   +11 more
europepmc   +2 more sources