Results 51 to 60 of about 21,550 (284)

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

BMC Biology, 2019
Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway ...
Neha M. Akella, Lorela Ciraku, Mauricio J. Reginato   +2 more
doaj   +1 more source

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

eLife, 2021
Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylation ...
Sydney Campbell, Clementina Mesaros, Luke Izzo, Hayley Affronti, Michael Noji, Bethany E Schaffer, Tiffany Tsang, Kathryn Sun, Sophie Trefely, Salisa Kruijning, John Blenis, Ian A Blair, Kathryn E Wellen   +12 more
doaj   +1 more source

Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes [PDF]

, 2012
Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy.
A Adaikalakoteswari, A AntonySunil, A Makino, A Turano, Anindita Das, AO Phillips, B Ashokkumar, B Dutta, B Sihag, BR Chamberlain, CME Tallaksen, Daniel Zehnder, ED Schleicher, Fang Zhang, G Gastaldi, GLJ Page, Guerman Molostvov, H Lum, H Smithline, HM Said, I Hubatsch, J Rieck, James R. Larkin, JC Reidling, JC Reidling, JC Reidling, JD Eudy, KA Robinson, Lisa Godfrey, MJ Boulware, MJ Ryan, MW Pfaffl, N Rabbani, N Rabbani, N Takahashi, N Tasevska, Naila Rabbani, Paul J. Thornalley, PJ Thornalley, R Babaei-Jadidi, S Sander, SM Nabokina, VS Subramanian   +42 more
core   +2 more sources

State-dependent fragmentation of protonated uracil and uridine [PDF]

, 2019
Tandem mass spectroscopy ($\textrm{MS}^2$) combined with single photon excitation in the VUV range (photon energy 4.5-9 eV) was performed on protonated uracil ($\textrm{UraH}^{+}$) and uridine ($\textrm{UrdH}^{+}$). The precursor ions with $m/z\;113$ and $m/z\;245$ respectively were produced by an Electrospray Ionization source (ESI) and accumulated ...
arxiv   +1 more source

UV resistance of nucleosides -- an experimental approach [PDF]

, 2020
The emergence of life on Earth is a highly discussed but still unsolved question. Current research underlines the importance of environments within close proximity to the Earth's surface as they can solve long-standing problems such as polymerization of nucleotides and phosphorylation of nucleosides.
arxiv   +1 more source

Galactose Epimerase Deficiency: Expanding the Phenotype [PDF]

, 2017
Galactose epimerase deficiency is an inborn error of metabolism due to uridine diphosphate-galactose-4'-epimerase (GALE) deficiency. We report the clinical presentation, genetic and biochemical studies in two siblings with generalized GALE deficiency ...
A Alano, DJ Lefeber, IB Sardharwalla, J Charlwood, J Wasilenko, JB Holton, JB Holton, JH Walter, KK Openo, L Sturiale, M Sarkar, MJ Henderson, R Gitzelmann, SS Sparrow, TM Wohlers   +14 more
core   +1 more source

Selective Detoxification of Phenols by Pichia pastoris and Arabidopsis thaliana Heterologously Expressing the PtUGT72B1 from Populus trichocarpa. [PDF]

PLoS ONE, 2013
Phenols are present in the environment and commonly in contact with humans and animals because of their wide applications in many industries. In a previous study, we reported that uridine diphosphate-glucose-dependent glucosyltransferase PtUGT72B1 from ...
Zhi-Sheng Xu, Ya-Qiu Lin, Jing Xu, Bo Zhu, Wei Zhao, Ri-He Peng, Quan-Hong Yao   +6 more
doaj   +1 more source

Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases

Frontiers in Physiology
Uridine is a pyrimidine nucleoside found in plasma and cerebrospinal fluid with a concentration higher than the other nucleosides. As a simple metabolite, uridine plays a pivotal role in various biological processes. In addition to nucleic acid synthesis,
Yueyuan Yang, Yahong Ye, Yingfeng Deng, Ling Gao   +3 more
doaj   +1 more source

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]

, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M., Alzahrani, Khalid J.H., Barrett, Michael P., Creek, Darren J., De Koning, Harry P., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A.   +7 more
core   +2 more sources

Trehalose Phosphate Synthesis from Uridine Diphosphate Glucose or Guanosine Diphosphate Glucose

Journal of Biological Chemistry, 1969
Abstract Cell-free extracts of a number of mycobacteria catalyzed the synthesis of trehalose phosphate from either uridine diphosphate-d-glucose or guanosine diphosphate-d-glucose and glucose 6-phosphate. A cell-free extract of Mycobacterium smegmatis was separated into two fractions by chromatography on diethylaminoethyl cellulose.
A. D. Elbein, Cecilia Liu, Betty W. Patterson, David F. Lapp   +3 more
openaire   +3 more sources