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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundType 2 diabetes mellitus is a major risk factor for cardiovascular disease; however, outcomes in individual patients vary. Soluble urokinase plasminogen activator receptor (suPAR) is a bone marrow–derived signaling molecule associated with ...
Salim S. Hayek +7 more
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Scientific Reports, 2018 PLAUR encodes the urokinase receptor (uPAR), which promotes cell survival, migration, and resistance to targeted cancer therapeutics in glioblastoma cells in culture and in mouse model systems.
Andrew S Gilder +9 more
semanticscholar +1 more source
Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer
EJNMMI Research, 2020 The urokinase plasminogen activator receptor (uPAR) plays a multifaceted role in almost any process where migration of cells and tissue-remodeling is involved such as inflammation, but also in diseases as arthritis and cancer. Normally, uPAR is absent in
V. Baart +7 more
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Neural Regeneration Research, 2020 The last two decades have witnessed a rapid decrease in mortality due to acute cerebral ischemia that paradoxically has led to a rapid increase in the number of patients that survive an acute ischemic stroke with various degrees of disability ...
Manuel Yepes
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The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis
Frontiers in Immunology, 2022 Skin fibrosis is a common pathological feature of various diseases, and few treatment strategies are available because of the molecular pathogenesis is poorly understood.
Ming-Li Zou +15 more
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Fibrinolytics: from the thrombolysis to the processes of blood vessels growth and remodeling, neurogenesis, carcinogenesis and fibrosis [PDF]
Терапевтический архив, 2019 One of the most outstanding scientific achievements in the thrombolysis is the development and administration of fibrinolysin - the first Soviet drug that lyses blood clots.
V A Tkachuk +7 more
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Scientific Reports, 2017 Early identification of patients at risk of developing diabetic nephropathy is essential. Elevated serum concentrations of soluble urokinase receptor (suPAR) associate with diabetes mellitus and predict onset and loss of renal function in chronic kidney ...
Martina Guthoff +7 more
semanticscholar +1 more source
Urokinase receptor genotypes in colorectal cancer [PDF]
Carcinogenesis, 1998 A previous study has reported a high frequency of rare alleles of the urokinase-type plasminogen activator receptor (uPAR) in a set of 15 colorectal cancer (CRC) cell lines. Our study investigated uPAR gene variation in 92 CRC patients and in tumour DNA from a subset of 69 patients using the PLAUR-IVS3 marker located in an intron of this gene.
M, Kohonen-Corish +3 more
openaire +2 more sources
Advanced Biomedical Research, 2017 Background: The objective of this study is to indicate the role of urokinase plasminogen activator receptor (uPAR), soluble uPAR (suPAR), and β1 integrin in tumor growth and invasion of lymph nodes from Hodgkin's lymphoma (HL) patients.
Shirin Kouhpayeh +5 more
doaj +1 more source