Results 31 to 40 of about 4,446 (160)
Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease [PDF]
, 2021 Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include ...
Singh H +9 more
core +4 more sources
Separation of Isomeric Forms of Urolithin Glucuronides Using Supercritical Fluid Chromatography [PDF]
, 2023 Urolithins are gut microbiota metabolites produced in humans after consuming foods containing ellagitannins and ellagic acid. Three urolithin metabotypes have been reported for different individuals depending on the final urolithins produced.
José Bernal +25 more
core +1 more source
Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases
Toxins, 2023 Neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease, significantly reduce the quality of life of patients and eventually result in complete maladjustment. Disruption of the synapses leads to a deterioration in the communication
Mark Makarov, Eduard Korkotian
doaj +1 more source
Biochemistry and Biophysics Reports, 2021 Ellagitannins (esters composed of glucose and ellagic acid) are hydrolyzed to generate ellagic acid in gut followed by conversion of ellagic acid to urolithins such as urolithin A by intestinal bacteria.
Hidehiko Kikuchi +3 more
doaj +1 more source
Cells, 2022 In the current study, for the first time, we study mitophagy enhancer urolithin A and a combination of urolithin A+green tea extract EGCG against human Aβ peptide-induced mitochondrial and synaptic, dendritic, inflammatory toxicities and behavioral ...
Sudhir Kshirsagar +8 more
doaj +1 more source
In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A [PDF]
, 2011 Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice.
Tai, Akihiro +6 more
core +2 more sources
Brain Sciences, 2021 Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors of colonic metabolite urolithin A, which are believed to contribute to pomegranate’s neuroprotective effect.
Małgorzata Kujawska +8 more
doaj +1 more source
Sarcopenia and Muscle Aging: A Brief Overview [PDF]
Endocrinology and Metabolism, 2020 The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global concerns.
Tam Dao +8 more
doaj +1 more source
, 2022 Urolithins (dibenzo-pyran-[b,d]-6 one derivatives) are human gut microbiota metabolites produced from the natural food antioxidant ellagic acid. Urolithins are better absorbed than ellagic acid and demonstrate biological activities that suggest that they
Laura Trulli (1663636) +11 more
core +1 more source
Frontiers in Pharmacology, 2020 Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins.
Linda Volpp +5 more
doaj +1 more source