Results 131 to 140 of about 4,757 (208)

A Systematic Study of the Hepatic–Intestinal First-Pass Effect and Excretion Pathways of Punicalagin Based on UPLC-MS/MS

Molecules
Punicalagin, the major polyphenol in pomegranate peel, shows broad bioactivity but suffers from poor oral bioavailability. Whether hepatic or intestinal first-pass processes dominate this limitation remains unresolved. We developed a quantitative UPLC-MS/
Zixin Chen, Zhanying Chang, Pengxia Yao, Xiaoli Gao   +3 more
doaj   +1 more source

Urolithins–gut Microbial Metabolites with Potential Health Benefits

The Open Medicinal Chemistry Journal
Urolithins are bioactive metabolites derived from the gut microbial transformation of ellagitannins found in various foods like pomegranates, berries, and nuts. These metabolites, primarily urolithin A and urolithin B, exhibit diverse biological activities, including anti-inflammatory, antioxidant, anticancer, neuroprotective, antiatherogenic ...
Maria Trapali, Vasiliki Lagouri
openaire   +1 more source

Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway

Journal of Natural Medicines
AbstractUrolithin families are gut-microbial metabolites of ellagic acid (EA). Although urolithin A (UA) and urolithin B (UB) were reported to have antiproliferative activities in cancer cells, the role and related mechanisms of urolithin C (UC) in colorectal cancer (CRC) have not yet been clarified. In this study, we assess the antitumor activities of
Yang, Haochi, Wu, Binghuo, yang, Qi, Tan, Tian, Shang, Dan, Chen, Jie, Cao, Chenhui, Xu, Chuan   +7 more
openaire   +2 more sources

Urolithin [PDF]

, 2020
openaire   +1 more source

Urolithin A ve yaşlı sağlığına güncel yaklaşım

Toros University Journal of Food, Nutrition and Gastronomy
Fizyolojik boyutuyla yaşlanma yaşlanma sürecine bağlı olarak yapı ve fonksiyonlardaki bozulmadır. Psikolojik boyutuyla yaşlanma ise bireylerin yaşlılık döneminde geçirdikleri davranış, uyum ve mental fonksiyonlarındaki değişimleri kapsar. Yaşlanma; evrensel, ilerleyici, kademeli ve engellenemez bir süreçtir.
openaire   +1 more source

Design, synthesis and biological evaluation of novel urolithin derivatives targeting liver cancer cells

Journal of Enzyme Inhibition and Medicinal Chemistry
We designed and synthesised 22 new urolithin derivatives (UDs) based on methyl-urolithin A (mUA) to identify anti-cancer drugs with high efficacy and low toxicity and evaluated their anti-cancer activities in vitro.
Mi Tian, Lirong Zhao, Yu Lan, Chen Li, Yipeng Ling, Benhong Zhou   +5 more
doaj   +1 more source

Process Optimization and Quality Evaluation of Pomegranate Juice Yogurt Fermented with Streptococcus thermophilus FUA329

Shipin gongye ke-ji
Metabolizing ellagic acid (EA) to urolithin A with numerous bioactivities significantly improve the nutritional value of food rich in EA. In the present study, Streptococcus thermophilus FUA329 was applied to prepare pomegranate juice yogurt.
Yichen HUANG, Ziyan HUA, Gewen ZHANG, Shu LIU, Xiaoyue HOU, Kexin CHI, Guang YANG, Xiang ZHOU, Yaowei FANG   +8 more
doaj   +1 more source

EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2015. Scientific Opinion on the substantiation of a health claim related to a combination of pomegranate pomace extract and greater galangal rhizome powder and an increase in the number of motile spermatozoa in semen pursuant to Article 13(5) of Regulation (EC) No 1924/2006 [PDF]

, 2015

core   +1 more source

Distinct classes of gut bacterial molybdenum-dependent enzymes produce urolithins. [PDF]

Proc Natl Acad Sci U S A
Bae M, Dong X, Avila-Pacheco J, Nguyen QD, Inyama F, Hill-Maini V, Clish CB, Balskus EP.   +7 more
europepmc   +1 more source

Regulation of skeletal muscle development and metabolism in broiler chickens by Urolithin A through threonine kinase 1 pathway activation. [PDF]

Poult Sci
Wu L, Peng L, Zhao X.
europepmc   +1 more source