Results 81 to 90 of about 21,131,763 (241)

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme [PDF]

Metabolites, 2020
Urolithins are gut microbial metabolites derived from ellagitannins (ET) and ellagic acid (EA), and shown to exhibit anticancer, anti-inflammatory, anti-microbial, anti-glycative and anti-oxidant activities. Similarly, the parent molecules, ET and EA are reported for their neuroprotection and antidepressant activities.
Rajbir Singh, Sandeep Chandrashekharappa, Praveen Kumar Vemula, Bodduluri Haribabu, Venkatakrishna Rao Jala   +4 more
openaire   +3 more sources

The role of antifungals agents on Candida glabrata biofilms matrix composition [PDF]

, 2010
Candida glabrata was considered, for years, a relatively non-pathogenic saprophyte of the normal flora of healthy individuals and as no causative agent of serious infection in humans.
Azeredo, Joana, Henriques, Mariana, Lourenço, T., Negri, M., Oliveira, Rosário, Silva, Sónia Carina   +5 more
core  

Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database [PDF]

, 2017
SCOPE: The Phenol-Explorer web database details 383 polyphenol metabolites identified in human and animal biofluids from 221 publications. Here we exploit these data to characterize and visualize the polyphenol metabolome, the set of all metabolites ...
Andrés Lacueva, Ma. Cristina, Barupal, Dinesh Kumar, Boto Ordóñez, María, Farran, Andreu, Llorach, Rafael, Manach, Claudine, Neveu, Vanessa, Rothwell, Joseph A., Scalbert, Augustin, Urpí Sardà, Mireia   +9 more
core   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Gut microbiota functions: metabolism of nutrients and other food components [PDF]

, 2017
The diverse microbial community that inhabits the human gut has an extensive metabolic repertoire that is distinct from, but complements the activity of mammalian enzymes in the liver and gut mucosa and includes functions essential for host digestion. As
A Alonso, A Belenguer, A Bordbar, A Braune, A Braune, A Duda-Chodak, A El Kaoutari, A Heinken, A Heinken, A Heinken, A Heinken, A Heinken, A Karau, A Marcobal, A Matthies, A Matthies, A Mohammed, A Quartieri, A-HM Emwas, A-M Davila, AF Hofmann, AJ Brown, AK Mallett, Almut Heinken, AR Rechner, AR Zomorrodi, AW Walker, AW Walker, B Goodwin, BE Gustafsson, BE Gustafsson, BV Jones, C Manach, C Noecker, CA Kolmeder, CA Kolmeder, CB Cole, CIR Gill, CJ Ziemer, CS Song, D Couteau, DH Mallonee, E Bauer, EA Franzosa, EA Smith, EM Lenz, EP Halmos, F Abram, F Bastos, F Suarez, F Tomas-Barberan, F Vadder De, FA Tomas-Barberan, FA Tomas-Barberan, FE Rowan, FM McIntosh, G Corona, G Falony, G Frost, G Wu, Glenn Gibson, GR Gibson, GR Gibson, GT Macfarlane, GT Macfarlane, GW Tannock, H Bernstein, H Hirokane, H Kettle, H Kettle, H Roume, H Tazoe, HM Said, I Rowland, Ian Rowland, IEJA Francois, Ines Thiele, J Eldere Van, J Pérez-Jiménez, J Trygg, JA Flick, JC Garcia-Canaveras, JC Young, JG Le Blanc, JH Cummings, JJ Eloranta, JK Nicholson, JM Landete, JM Ridlon, JM Ridlon, Jonathan Swann, JR Marchesi, JR Swann, JT Bjerrum, JW Lampe, K Decroos, K Steliou, K Watanabe, Karen Scott, Kieran Tuohy, KP Scott, KR Stayrook, L Hanske, L Hanske, L Marín, L Tasse, L Tomasova, LA Woollett, LV Hooper, M Begley, M Blaut, M Dabek, M Hermanussen, M Rajilić-Stojanović, M Vital, M Watanabe, M Watanabe, MB Biggs, MD Levitt, MGM Kok, MJ Gosalbes, MJ Hill, MV Selma, N Reichardt, NC Verberkmoes, NE Lewis, O Manor, P Kurdi, P Louis, P Louis, P Louis, P Louis, Palsson BØ, PC Pircher, PG Frick, PG Wolf, PJ Turnbaugh, Q Zhang, R Madsen, R Muñoz-Tamayo, RL Kandell, S El Aidy, S Greenblum, S Katsuma, S Lockyer, S Magnúsdóttir, S Possemiers, SA Gibson, SA Joyce, SD Boyd, SF Lajoie, SH Duncan, SH Duncan, SH Hussaini, SM Houten, SN Steinway, SU Christl, SU Christl, T Clavel, T Clavel, T Shashkova, W Xiong, W-L Wang, WR Russell, WR Russell, WR Wikoff, X Shen, X Wei, Y Wang, Z Wang, Z-L Dai, Z-L Dai   +171 more
core   +3 more sources

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Targeting aging with urolithin A in humans: A systematic review

Ageing Research Reviews
Urolithin A (UA) is a gut metabolite derived from ellagic acid. This systematic review assesses the potential geroprotective effect of UA in humans. In five studies including 250 healthy individuals, UA (10-1000 mg/day) for a duration ranging from 28 days to 4 months, showed a dose-dependent anti-inflammatory effect and upregulated some mitochondrial ...
Kuerec, AH, Lim, XK, Khoo, AL, Sandalova, E, Guan, L, Feng, L, Maier, AB   +6 more
openaire   +3 more sources

Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases

Nutrients, 2022
Urolithin A (Uro A) is a dietary metabolite of the intestinal microbiota following the ingestion of plant-based food ingredients ellagitannins and ellagic acid in mammals. Accumulating studies have reported its multiple potential health benefits in a broad range of diseases, including cardiovascular disease, cancer, cognitive impairment, and diabetes ...
Kailin Li, Yao Xiao, Ji Bian, Lin Han, Caian He, Emad El-Omar, Lan Gong, Min Wang   +7 more
openaire   +3 more sources

Supplementation of Weizmannia coagulans BC2000 and Ellagic Acid Inhibits High-Fat-Induced Hypercholesterolemia by Promoting Liver Primary Bile Acid Biosynthesis and Intestinal Cholesterol Excretion in Mice

Microorganisms, 2023
The probiotic Weizmannia coagulans (W. coagulans) BC2000 can increase the abundance of intestinal transforming ellagic acid (EA) bacteria and inhibit metabolic disorders caused by hyperlipidemia by activating liver autophagy.
Long Jin, Hongyang Dang, Jinyong Wu, Lixia Yuan, Xiangsong Chen, Jianming Yao   +5 more
doaj   +1 more source