Results 101 to 110 of about 2,363 (194)
Frontiers in Pharmacology, 2020 Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins.
Linda Volpp +5 more
doaj +1 more source
Gut microbiota modulation of chemotherapy efficacy and toxicity [PDF]
, 2017 Evidence is growing that the gut microbiota modulates the host response to chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; abrogation and compromise of anticancer effects; and mediation of toxicity.
Alexander, James L. +5 more
core +1 more source
CDK12 Inactivation Attenuates Prostate Cancer Progression by Inhibiting BNIP3‐Mediated Mitophagy
Cell Proliferation, Volume 59, Issue 2, February 2026.In response to enzalutamide, damaged mitochondria are targeted for mitophagic degradation through the binding of BNIP3 to LC3, forming autophagosomes that are subsequently transported to lysosomes for degradation. These self‐protective mechanisms promote mitochondrial renewal, reduce oxidative stress and finally contribute to cancer cell survival ...
Mengjun Huang +13 more
wiley +1 more source
Cell Proliferation, Volume 59, Issue 2, February 2026.The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu +5 more
wiley +1 more source
Phytoestrogen Metabolism by Adult Human Gut Microbiota
Molecules, 2016 Phytoestrogens are plant-derived polyphenols with a structure similar to human estrogens. The three main groups of phytoestrogens, isoflavones, ellagitannins, and lignans, are transformed into equol, urolithins, and enterolignans, respectively, by ...
Pilar Gaya +3 more
doaj +1 more source
Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications [PDF]
, 2023 Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables.
Abdelwareth, Amr +6 more
core +1 more source
FEBS Open Bio, Volume 16, Issue 1, Page 11-24, January 2026.Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui +3 more
wiley +1 more source
Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review
Medicine Bulletin, Volume 2, Issue 1, Page 94-123, January 2026.ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng +8 more
wiley +1 more source
Food Frontiers, 2020 Polyphenols are plant‐derived natural compounds, which are attributed to various beneficial effects on human health. Therefore, they are extensively investigated in different experimental setups.
Stoyan Dirimanov, Petra Högger
doaj +1 more source
An Integrated Engineering Approach to Creating Health‐Modulating Postbiotics
Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.Postbiotics have emerged as a promising alternative to live probiotics, offering comparable health benefits while overcoming challenges related to safety, stability, and shelf life. The review addresses current challenges in standardizing postbiotic definitions and production processes, and by outlining future research directions necessary to unlock ...
Michael Leonidas Chikindas +10 more
wiley +1 more source