Results 181 to 190 of about 2,363 (194)

Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo

Journal of Agricultural and Food Chemistry, 2022
Urolithin A (UA) is a metabolite produced in the gut following the consumption of ellagic acid (EA) rich foods. EA has shown anti-inflammatory, antioxidant, and anticancer properties. Because EA is poorly absorbed in the gastrointestinal tract, urolithins are considered to play a major role in bioactivity. Helicobacter pylori (H.
Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li, Tian-yi Li, Qian Chen, Jian Zhao   +9 more
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The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells

Food and Chemical Toxicology, 2020
The promotion of senescence in cancer cells by dietary (poly)phenols gained attention as a promising chemopreventive strategy against colorectal (CRC) and other cancers. Urolithins (Uros) are ellagitannins and ellagic acid-derived gut microbiota metabolites that reach high concentrations in the human colon.
Juan Antonio, Giménez-Bastida, María Ángeles, Ávila-Gálvez, Juan Carlos, Espín, Antonio, González-Sarrías   +3 more
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Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins

Journal of Agricultural and Food Chemistry, 2010
Pomegranate juice derived ellagitannins and their intestinal bacterial metabolites, urolithins, inhibited TCDD-induced CYP1-mediated EROD activity in vitro with IC(50) values ranging from 56.7 microM for urolithin A to 74.8 microM for urolithin C.
Sashi G, Kasimsetty, Dobroslawa, Bialonska, Muntha K, Reddy, Guoyi, Ma, Shabana I, Khan, Daneel, Ferreira   +5 more
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Urolithin A Nanoparticle Therapy for Cisplatin-Induced Acute Kidney Injury

Nephron, 2022
Cisplatin continues to be one of the frontline cytotoxic drugs. However, cisplatin-induced acute kidney injury (AKI) remains a major unmet medical need without any approved pharmacological interventions. The involvement of reactive oxygen species generation and activation of inflammatory and apoptotic pathways in the pathogenesis of cisplatin-induced ...
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Synthesis of urolithin derivatives and their anti-inflammatory activity

Biochemical and Biophysical Research Communications
Two series of urolithin derivatives, totally 38 compounds, were synthesized. Their anti-inflammatory activity was investigated by detecting the inhibitory effects on the expression of TNF-α in bone marrow-derived macrophages (BMDMs), showing that 24 of 38 ones reduced the expression of TNF-α.
Xintong Li, Zhengzheng Zhang, Guangsen Xu, Zhiying Li, Chunhua Lu, Yuemao Shen   +5 more
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Appeal of Urolithins from Synthesis to Biological Activities

Journal of Agricultural and Food Chemistry
Urolithins (Uros), a series of natural polyphenols derived from ellagic acid through gut bacteria metabolism, have gathered significant attention due to their diverse bioactivities such as maintaining mitochondrial health and anti-inflammatory and antioxidative effects. However, the ability to metabolize Uros varies among individuals.
Huanyu Xu, Danyu Lv, Yongguang Guan
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Urolithin B protects PC12 cells against glutamate-induced toxicity

Molecular Biology Reports
The involvement of malfunctioning glutamate systems in various central nervous system (CNS) disorders is widely acknowledged. Urolithin B, known for its neuroprotective and antioxidant properties, has shown potential as a therapeutic agent for these disorders.
Israa, Aljabouri, Mehdi, Rostami, Farshad, Mirzavi, Mahla Kazemian, Kakhki, Abbas, Alalikhan, Elaheh, Gheybi, Ali, Hakimi, Mohammad, Soukhtanloo   +7 more
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Improvement of Urolithin A Yield by In Vitro Cofermentation of Streptococcus thermophilus FUA329 with Human Gut Microbiota from Different Urolithin Metabotypes

Journal of Agricultural and Food Chemistry
Streptococcus thermophilus FUA329 converts ellagic acid (EA) to urolithin A (Uro-A), which is not autonomously converted by the gut microbiota to produce highly bioavailable and multibiologically active Uro-A in urolithin metabotype 0 (UM-0) populations. We consider that Streptococcus thermophilus FUA329 has the potential to be developed as a probiotic.
Mengjie Xia, Ziyan Hua, Yaling Zhao, Gewen Zhang, Xiaoyue Hou, Guang Yang, Shu Liu, Yaowei Fang   +7 more
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Total Synthesis of Urolithin C 3-Glucuronide

HETEROCYCLES, 2021
Hitoshi Abe, Katsunori Itaya, Ishtiaq Jeelani   +2 more
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Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy

International Immunopharmacology
Radiation pneumonitis (RP) is a common and severe complication of radiotherapy, whose pathogenesis involves complex inflammatory responses and cellular damage. Despite its clinical significance, effective treatments remain limited. This study investigates the role of radiation-induced PINK1/PRKN-mediated mitophagy and type I interferon responses in RP ...
Anqi, Zhang, Shilan, Luo, Peng, Li, Lu, Meng, Litang, Huang, Hongxia, Cheng, Chenhui, Zhao, Hongbin, Tu, Xiaomei, Gong   +8 more
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