Results 61 to 70 of about 2,520 (194)
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Jiajun Qiao +5 more
wiley +1 more source
High USP22 expression indicates poor prognosis in hepatocellular carcinoma
Oncotarget, 2015 Ubiquitin-specific protease 22 (USP22) removes ubiquitin from histones, thus regulating gene transcription. The expression frequency and expression levels of USP22 were significantly higher in hepatocellular carcinoma (HCC) than in normal liver tissues.
Bo, Tang +8 more
openaire +3 more sources
Tumor Cell–Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer
Cancer Immunology Research, 2020 Abstract Although immune checkpoint blockade (ICB) improves clinical outcome in several types of malignancies, pancreatic ductal adenocarcinoma (PDA) remains refractory to this therapy. Preclinical studies have demonstrated that the relative abundance of suppressive myeloid cells versus cytotoxic T cells determines the efficacy of ...
Jinyang Li +6 more
openaire +3 more sources
USP22 Promotes NSCLC Tumorigenesis via MDMX Up-Regulation and Subsequent p53 Inhibition
, 2014 Increasing evidence suggests that ubiquitin-specific protease 22 (USP22) has great clinicopathologic significance in oncology. In this study, we investigated the role of USP22 in human NSCLC tumorigenesis along with the underlying mechanisms of action ...
Xiao Xie +7 more
core +1 more source
Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets
MedComm, Volume 7, Issue 6, June 2026.FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li +10 more
wiley +1 more source
PKA/CREB regulates the constitutive promoter activity of the USP22 gene
Oncology Reports, 2015 The human ubiquitin-specific processing enzyme 22 (USP22) plays a crucial role in regulating cell cycle processes and its overexpression has been linked to tumor progression. However, the mechanisms leading to USP22 transcriptional activation in human cancer cells are still unclear.
Jianjun, Xiong +7 more
openaire +3 more sources
, 2020 SF1: Analysis of USP22 expression with known drivers of disease progression; SF2: USP22 modulates DNA repair factors expression and survival after DNA damage; SF3: Genetically engineered mouse model of tumor-associated USP22 expression; SF4: The USP22 ...
Irina A. Vasilevskaya (14943550) +14 more
core +1 more source
, 2023 Post-translational modifications (PTMs) of cell fate regulating proteins determine their stability, localization and function and control the activation of cell protective signaling pathways.
Kowald, Lisa
core +1 more source
The Deubiquitinase USP22 Modulates Regulatory T-cell Function [PDF]
Cancer Discovery, 2020 Abstract USP22 positively regulated transcription factor FOXP3 activity in mouse regulatory T (Treg) cells.
openaire +1 more source
, 2023 The study aims to explore the role of A1BG antisense RNA 1 (A1BG-AS1), microRNA (miR)-148a-3p and ubiquitin-specific protease 22 (USP22) on osteosarcoma (OS) cell growth.
Mengxue Hu (14199419) +9 more
core +1 more source