Results 41 to 50 of about 2,520 (194)

USP22 is useful as a novel molecular marker for predicting disease progression and patient prognosis of oral squamous cell carcinoma. [PDF]

PLoS ONE, 2012
BACKGROUND AND OBJECTIVE:The significance of ubiquitin-specific protease 22 (USP22) as a potential marker has been growing in the field of oncology. The aim of this study was to investigate the role of USP22 and the association with its potential targets
Songlin Piao, Yanlong Liu, Jing Hu, Fulin Guo, Jie Ma, Yao Sun, Bin Zhang   +6 more
doaj   +1 more source

USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin

Oncology Letters, 2020
Renal cell carcinoma (RCC) is one of the commonest urological tumors. The incidence of RCC ranks third among urological tumors, after prostate cancer and bladder tumors. However, the etiology of RCC remains unclear. Ubiquitin-specific protease 22 (USP22), a potential marker of cancer stem cells, is associated with the occurrence and progression of ...
Ying, Lin, Hongbin, Zhong, Baicheng, Sun, Yongtiao, Peng, Fuhua, Lu, Miaoxuan, Chen, Maoshu, Zhu, Jiyi, Huang   +7 more
openaire   +3 more sources

Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer

European Journal of Histochemistry, 2012
Ubiquitin-specific protease 22 (USP22), a novel ubiquitin hydrolase, has been implicated in oncogenesis and cancer progression in various types of human cancer.
J. Ning, J. Zhang, W. Liu, Y. Lang, Y. Xue, S. Xu   +5 more
doaj   +1 more source

USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression

Aging, 2020
Ubiquitin-specific protease 22 (USP22) expresses highly in lung adenocarcinoma (LUAD), which are associated with poor overall survival (OS). Microarray processing was performed to determine gene expression profiling, in which it was found that knocking down USP22 resulted in abnormal expression of a large number of genes. Differentially expressed genes
Han, Bing, Sun, Yue, Yang, Dongdong, Zhang, Huijuan, Mo, Steven, Chen, Xuesong, Lu, Hailing, Mao, Xueyan, Hu, Jing   +8 more
openaire   +2 more sources

The Cellular Function of USP22 and its Role in Tissue Maintenance and Tumor Formation [PDF]

, 2017
Colorectal cancer (CRC) is the most frequent malignancy of the gastrointestinal tract and therefore reflects a global health issue. Despite improved detection and treatment options the high mortality and morbidity rates of this disease emphasize the ...
Kosinsky, Robyn Laura
core   +1 more source

USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent autophagy

, 2022
The NLRP3 inflammasome is involved in a diverse range of inflammatory diseases. The activation of inflammasomes must be tightly regulated to prevent excessive inflammation, and the protein ubiquitination system is reported to be one of the ways in which ...
Jiazheng Quan (5830505), Qianqian Di (4352785), Haimei Tang (11879490), Han Wu (218687), Zherui Wu (12176639), Weilin Chen (643171), Xunwei Li (12998106), Xibao Zhao (12176636), Yue Xiao (830802)   +8 more
core   +1 more source

Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner

Cancer Cell International, 2020
Background Aberrant expression of ubiquitin-specific peptide 22 (USP22) has been detected in various cancers. This study aimed to investigate the role of USP22 and the underlying mechanism in human gastric cancer.
ChitChoon Lim, Jia-Cheng Xu, Tian-Yin Chen, Jia-Xin Xu, Wei-Feng Chen, Jian-Wei Hu, Quan-Lin Li, Yi-Qun Zhang   +7 more
doaj   +1 more source

Immune Evasion and Drug Resistance Mediated by USP22 in Cancer: Novel Targets and Mechanisms

Frontiers in Immunology, 2022
Regulation of ubiquitination is involved in various processes in cancer occurrence and development, including cell cycle arrest, cell proliferation, apoptosis, invasion, metastasis, and immunity.
Jinhui Guo, Jinhui Guo, Jie Zhao, Wen Fu, Qiuran Xu, Dongsheng Huang   +5 more
doaj   +1 more source

USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression [PDF]

Cancer Research, 2014
Abstract Increasing evidence links deregulation of the ubiquitin-specific proteases 22 (USP22) deubitiquitylase to cancer development and progression in a select group of tumor types, but its specificity and underlying mechanisms of action are not well defined.
Randy S, Schrecengost, Jeffry L, Dean, Jonathan F, Goodwin, Matthew J, Schiewer, Mark W, Urban, Timothy J, Stanek, Robyn T, Sussman, Jessica L, Hicks, Ruth C, Birbe, Rossitza A, Draganova-Tacheva, Tapio, Visakorpi, Angelo M, DeMarzo, Steven B, McMahon, Karen E, Knudsen   +13 more
openaire   +2 more sources

Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma

International Journal of Oncology, 2015
Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor type, ranking as the third leading cause of all cancer-related deaths in the world. The post-surgical 5-year survival rate is low, largely due to the high recurrence rate. Therefore, the identification of target molecules that control the biological characteristics of HCC ...
Tang, Bo, Liang, Xingsi, Tang, Fang, Zhang, Jing, Zeng, Sien, Jin, Shengjian, Zhou, Lihua, Kudo, Yasusei, Qi, Guangying   +8 more
openaire   +3 more sources