Results 21 to 30 of about 2,520 (194)
Cells, 2022 Sorafenib is a small molecule that blocks tumor proliferation by targeting the activity of multi-kinases for the treatment of advanced hepatocellular carcinoma (HCC). Increasing sorafenib resistance following long-term treatment is frequently encountered.
Yung-Sheng Chang +5 more
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Differential expression of USP22 in amyotrophic lateral sclerosis.
, 2022 Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression ...
Shahan Mamoor
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USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination [PDF]
EMBO reports, 2020 Dynamic control of ubiquitination by deubiquitinating enzymes is essential for almost all biological processes. Ubiquitin-specific peptidase 22 (USP22) is part of the SAGA complex and catalyzes the removal of mono-ubiquitination from histones H2A and H2B, thereby regulating gene transcription.
Jens Roedig +8 more
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Inhibition of USP22 by miR-200b-5p represses gastric cancer cell proliferation and migration by targeting the NF-κB signaling pathway [PDF]
Acta Biochimica et Biophysica SinicaGastric cancer (GC) is an aggressive tumor type with an intricate pathogenesis and limited therapeutic options. Ubiquitin-specific protease 22 (USP22) is a protein implicated in cell proliferation, metastasis, and tumorigenesis.
Guo Yingying +7 more
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Identification of potential target genes of USP22 via ChIP-seq and RNA-seq analysis in HeLa cells
Genetics and Molecular Biology, 2018 The ubiquitin-specific protease 22 (USP22) is an oncogene and its expression is upregulated in many types of cancer. In the nucleus, USP22 functions as one subunit of the SAGA to regulate gene transcription.
Zhen Gong +8 more
doaj +2 more sources
USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis [PDF]
Frontiers in Pharmacology, 2017 Resistance to platinum-based chemotherapy is one of the most important reasons for treatment failure in advanced non-small cell lung cancer, but the underlying mechanism is extremely complex and unclear.
Aman Wang +7 more
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The Deubiquitinase USP22‐Stabilized COL17A1 Promotes Lung Adenocarcinoma Progression
The Clinical Respiratory JournalBackground Lung adenocarcinoma (LUAD) is a highly aggressive and rapidly fatal malignancy worldwide. Collagen XVII (COL17A1) has been implicated in various protumorigenic processes.
Guangxi Chen +3 more
doaj +3 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Pancreatic cancer (PC) is an aggressive malignancy with a poor survival rate. Despite advances in the treatment of PC, the efficacy of therapy is limited by the development of chemoresistance.
Limin Huang +7 more
doaj +2 more sources
PLoS ONEThe Ubiquitin Specific Peptidase 22 (USP22), a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear.
Xianghong Kuang +5 more
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Cell Communication and SignalingBackground Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response in early- and non-metastatic disease stages.
Evangelos Prokakis +9 more
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