Results 31 to 40 of about 2,520 (194)

Bioinformatic analysis of the role of USP22 expression in hepatocellular carcinoma. [PDF]

Int J Clin Exp Pathol
Liver hepatocellular carcinoma (LIHC) is the most prevalent liver malignancy, often diagnosed at advanced stages, and resulting in a poor prognosis for patients. Ubiquitin-specific peptidase 22 (USP22) belongs to the ubiquitin-specific processing proteases (USPs) subfamily and has been identified as a gene signature associated with various cancer types
Xu K, Lu Y.
europepmc   +4 more sources

Usp22 is an intracellular regulator of systemic emergency hematopoiesis

Science Immunology, 2022
Emergency hematopoiesis is a concerted response aimed toward enhanced protection from infection, involving multiple cell types and developmental stages across the immune system. Despite its importance, the underlying molecular regulation remains poorly understood.
Nikolaus Dietlein, Xi Wang, Jonas Metz, Olivier Disson, Fuwei Shang, Celine Beyersdörffer, Esther Rodríguez Correa, Daniel B. Lipka, Yvonne Begus-Nahrmann, Robyn Laura Kosinsky, Steven A. Johnsen, Marc Lecuit, Thomas Höfer, Hans-Reimer Rodewald   +13 more
openaire   +4 more sources

Ubiquitin‐specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma

MedComm, 2023
Ubiquitin‐specific protease 22 (USP22) has been identified as a potential marker for cancer stem cells in hepatocellular carcinoma (HCC). It can promote HCC stemness, which is considered a driver of tumorigenesis. Here, we sought to determine the role of
Qianwei Ye, Wei Zhou, Shengjun Xu, Qingyang Que, Qifan Zhan, Lincheng Zhang, Shusen Zheng, Sunbin Ling, Xiao Xu   +8 more
doaj   +1 more source

Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression

Cell Communication and Signaling, 2022
Background Ubiquitin-specific protease 22 (USP22), a putative cancer stem cell marker, is frequently upregulated in cancers, and USP22 overexpression is associated with aggressive growth, metastasis, and therapy resistance in various human cancers ...
Ting Sun, Keqiang Zhang, Wendong Li, Yunze Liu, Rajendra P. Pangeni, Aimin Li, Leonidas Arvanitis, Dan J. Raz   +7 more
doaj   +1 more source

Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma. [PDF]

PLoS ONE, 2014
Salivary Adenoid Cystic Carcinoma (SACC) is characterized by a high rate of local recurrence and infiltration, strong invasion to peripheral nerves or late distant metastasis.
Wei Dai, Yuan Yao, Qing Zhou, Chang-fu Sun   +3 more
doaj   +1 more source

Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma

Cell Death and Disease, 2021
Oncogenic ubiquitin-specific protease 22 (USP22) is implicated in a variety of tumours; however, evidence of its role and underlying molecular mechanisms in cholangiocarcinoma (CCA) development remains unknown. We collected paired tumour and adjacent non-
Yu Tian, Bo Tang, Chengye Wang, Yan Wang, Jiakai Mao, Yifan Yao, Zhenming Gao, Rui Liang, Mingliang Ye, Shijie Cai, Liming Wang   +10 more
doaj   +1 more source

Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8⁺ T Cells and Causes Immunopathology in Response to Acute LCMV Infection

Vaccines, 2023
Ubiquitin-specific peptidase 22 (Usp22) cleaves ubiquitin moieties from numerous proteins, including histone H2B and transcription factors. Recently, it was reported that Usp22 acts as a negative regulator of interferon-dependent responses.
Justa Friebus-Kardash, Theresa Charlotte Christ, Nikolaus Dietlein, Abdelrahman Elwy, Hossam Abdelrahman, Lisa Holnsteiner, Zhongwen Hu, Hans-Reimer Rodewald, Karl Sebastian Lang   +8 more
doaj   +1 more source

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma

Nature Communications, 2022
Abstract Elevated de novo lipogenesis is considered to be a crucial factor in hepatocellular carcinoma (HCC) development. Herein, we identify ubiquitin-specific protease 22 (USP22) as a key regulator for de novo fatty acid synthesis, which directly interacts with deubiquitinates and stabilizes peroxisome proliferator-activated ...
Zhen Ning, Xin Guo, Xiaolong Liu, Chang Lu, Aman Wang, Xiaolin Wang, Wen Wang, Huan Chen, Wangshu Qin, Xinyu Liu, Lina Zhou, Chi Ma, Jian Du, Zhikun Lin, Haifeng Luo, Wuxiyar Otkur, Huan Qi, Di Chen, Tian Xia, Jiwei Liu, Guang Tan, Guowang Xu, Hai-long Piao   +22 more
openaire   +3 more sources

Inhibition of USP7 upregulates USP22 and activates its downstream cancer-related signaling pathways in human cancer cells

Cell Communication and Signaling, 2023
Deubiquitinases (DUBs) play important roles in various human cancers and targeting DUBs is considered as a novel anticancer therapeutic strategy. Overexpression of ubiquitin specific protease 7 and 22 (USP7 and USP22) are associated with malignancy ...
Keqiang Zhang, Ting Sun, Wendong Li, Yuming Guo, Aimin Li, Marcus Hsieh, Jinghan Wang, Jun Wu, Leonidas Arvanitis, Dan J. Raz   +9 more
doaj   +1 more source

USP22 as a key regulator of glycolysis pathway in osteosarcoma: insights from bioinformatics and experimental approaches [PDF]

PeerJ
Background Osteosarcoma is the most common primary malignant bone tumor, but its pathogenesis remains unclear. Ubiquitin-specific processing peptidase 22 (USP22) is reported to be highly expressed and associated with tumor malignancy and prognosis in ...
Qiao Zhang, Jinwei Zhu, Jian Xie, Yurong Gu, Lu Chen   +4 more
doaj   +2 more sources