Results 11 to 20 of about 2,520 (194)

Cloning and characterization of the human USP22 gene promoter. [PDF]

PLoS ONE, 2012
Ubiquitin-specific processing enzyme 22 (USP22) plays a direct role in regulating cell cycle, and its overexpression has been reported to be involved in tumor progression. However, little is known about the regulation of USP22 transcription.
Jianjun Xiong, Xiangxin Che, Xueqin Li, Huan Yu, Zhen Gong, Weidong Li   +5 more
doaj   +5 more sources

A positive feedback loop of SRSF9/USP22/ZEB1 promotes the progression of ovarian cancer [PDF]

Cancer Biology & Therapy
Ovarian cancer (OC) is recognized as the most lethal type of gynecological malignancy, making treatment options challenging. Discovering novel therapeutic targets will benefit OC patients. This study aimed to reveal the mechanism by which SRSF9 regulates
Jing Wang, Ming Hu, Jie Min, Xin Li
doaj   +3 more sources

USP22 promotes gefitinib resistance and inhibits ferroptosis in non‐small cell lung cancer by deubiquitination of MDM2 [PDF]

Thoracic Cancer
Background The emergence of chemoresistance markedly compromised the treatment efficiency of human cancer, including non‐small cell lung cancer (NSCLC). In the present study, we aimed to explore the effects of ubiquitin‐specific peptidase 22 (USP22) and ...
Peng Lu, Zhaoguo Li, Hang Xu
doaj   +3 more sources

Deubiquitination in prostate cancer progression: role of USP22 [PDF]

Journal of Cancer Metastasis and Treatment, 2020
Prostate cancer (PCa) is the leading cause of cancer death in men. With more therapeutic modalities available, the overall survival in PCa has increased significantly in recent years. Patients with relapses after advanced secondgeneration anti-androgen therapy however, often show poor disease prognosis.
Nag, Nivedita, Dutta, Samikshan
openaire   +3 more sources

Ubiquitin-Specific Peptidase USP22 Negatively Regulates the STAT Signaling Pathway by Deubiquitinating SIRT1

Cellular Physiology and Biochemistry, 2014
Background/Aims: The ubiquitin-specific peptidase USP22 mediates various cellular and organismal processes, such as cell growth, apoptosis, and tumor malignancy.
Ning Ao, Yanyan Liu, Hailiang Feng, Xiaocui Bian, Zhanwen Li, Bei Gu, Xiaomei Zhao, Yuqin Liu   +7 more
doaj   +2 more sources

The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells [PDF]

Cell Communication and Signaling, 2020
Background Many cancers evade immune surveillance by overexpressing PD-L1. PD-L1 interacted with its receptor PD-1, resulting in reduction of T cell proliferation and activation and thereafter cancer cell death mediated by T-lymphocyte. Understanding the
Yu Wang, Qingguo Sun, Ning Mu, Xiaoyang Sun, Yingying Wang, Songqing Fan, Ling Su, Xiangguo Liu   +7 more
doaj   +3 more sources

Usp22 deficiency impairs intestinal epithelial lineage specification in vivo [PDF]

Oncotarget, 2015
Epigenetic regulatory mechanisms play a central role in controlling gene expression during development, cell differentiation and tumorigenesis. Monoubiquitination of histone H2B is one epigenetic modification which is dynamically regulated by the opposing activities of specific ubiquitin ligases and deubiquitinating enzymes (DUBs).
Kosinsky, Robyn L., Wegwitz, Florian, Hellbach, Nicole, Dobbelstein, Matthias, Mansouri, Ahmed, Vogel, Tanja, Begus-Nahrmann, Yvonne, Johnsen, Steven A.   +7 more
openaire   +7 more sources

USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma

Cell Death and Disease, 2023
Hepatocellular carcinoma (HCC) is a common solid tumor with high rate of recurrence and mortality. Anti-angiogenesis drugs have been used for the therapy of HCC. However, anti-angiogenic drug resistance commonly occurs during HCC treatment.
Kai Zeng, Weiwen Xie, Chunyu Wang, Shengli Wang, Wei Liu, Yingjie Su, Lin Lin, Renlong Zou, Ge Sun, Baosheng Zhou, Manlin Wang, Ruina Luan, Yu Bai, Yunlong Huo, Shigeaki Kato, Xinping Zhong, Yue Zhao   +16 more
doaj   +3 more sources

Varions Mechanisms of Deubiquitinating Enzyme USP22 in Cancer

Zhongliu Fangzhi Yanjiu, 2020
Ubiquitin specific proteases 22 (USP22) is a highly conserved ubiquitin hydrolase in mammals. It mainly prevents proteins degradation by deubiquitinating substrate proteins and regulates life processes such as genetic transcription, DNA damage repair and
SUN Yue, HAN Bing, ZHEN Fang, HU Jing
doaj   +2 more sources

USP22 is a positive regulator of NFATc2 on promoting IL2 expression [PDF]

FEBS Letters, 2014
Nuclear factor of activated T cells (NFAT) is an important regulator of T cell activation. However, the molecular mechanism whereby NFATc2 regulates IL2 transcription is not fully understood. In this study, we showed that ubiquitin‐specific protease 22 (USP22), known as a cancer stem cell marker, specifically interacted with and deubiquitinated NFATc2.
Gao, Yayi, Lin, Fang, Xu, Peng, Nie, Jia, Chen, Zuojia, Su, Jinsong, Tang, Jiayou, Wu, Qingsi, Li, Yangyang, Guo, Zhixiang, Gao, Zhimei, Li, Dan, Shen, Jijia, Ge, Shenglin, Tsun, Andy, Li, Bin   +15 more
openaire   +3 more sources