Results 1 to 10 of about 2,520 (194)

USP22 enhances atherosclerotic plaque stability and macrophage efferocytosis by stabilizing PPARγ [PDF]

Communications Biology
Atherosclerosis is a chronic inflammatory disease that strongly threatens human health, and macrophages play a pivotal role in its pathogenesis. Ubiquitin-specific peptidase 22 (USP22) is involved in the regulation of macrophage inflammation.
Senhu Tang, Chuanghong Lu, Zhongyuan Meng, Zihua Ye, Yue Qin, Na Na, Shenglin Xian, Feng Huang, Zhiyu Zeng   +8 more
doaj   +5 more sources

METTL14-mediated m6A modification enhances USP22-ERα axis to drive breast cancer malignancy

Pharmacological Research
The abundance and activity of estrogen receptor alpha (ERα) are tightly regulated by ubiquitin-specific peptidase 22 (USP22) during the progression of breast cancer (BCa).
Gengxi Cai
exaly   +4 more sources

A chromatin-focused CRISPR screen identifies USP22 as a barrier to somatic cell reprogramming [PDF]

Communications Biology
Cell-autonomous barriers to reprogramming somatic cells into induced pluripotent stem cells (iPSCs) remain poorly understood. Using a focused CRISPR-Cas9 screen, we identified Ubiquitin-specific peptidase 22 (USP22) as a key chromatin-based barrier to ...
Gülben Gürhan, Kenan Sevinç, Can Aztekin, Mert Gayretli, Alperen Yılmaz, Abdullah Burak Yıldız, Elif Naz Ervatan, Tunç Morova, Elif Datlı, Oliver D. Coleman, Akane Kawamura, Nathan A. Lack, Hamzah Syed, Tamer Önder   +13 more
doaj   +3 more sources

USP22 promotes the proliferation and Sorafenib resistance of hepatocellular carcinoma cells via its deubiquitinase activity [PDF]

Clinical and Translational Medicine
Background Hepatocellular carcinoma remains one of the most lethal cancers, characterized by poor prognosis and low life expectancy. Unfortunately, there are very few molecular therapeutic options available for it.
Xiaochen Wang, Yijie Su, Bei Lan, Xuanyuan Li, Bodi Zhang, Liang Zhang, Yingmei Wang, Chunze Zhang, Chenghao Xuan   +8 more
doaj   +3 more sources

Targeting ubiquitin-specific peptidase 22 in solid tumours: from ubiquitination to immunotherapy [PDF]

Frontiers in Cell and Developmental Biology
As a deubiquitinating enzyme, the function of ubiquitin-specific peptidase 22 (USP22) in tumours has attracted increasing attention. However, the regulatory mechanism underlying USP22’s tumour biological processes has not yet been thoroughly elucidated ...
Zhe Li, Liming Wang, Jingyi Liu, Yuanxin Tang   +3 more
doaj   +2 more sources

Decoding the Oncogenic Role of USP22 Through Pan-Cancer Genomic and Epigenetic Analysis. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Ubiquitin‐specific protease 22, an important catalytic component of the human SAGA (Spt‐Ada‐GcN5 Acetyltransferase) complex, regulates the deubiquitination and methylation of histones, which in turn influences gene expression. Its overexpression alters gene regulation, transcription, cancer progression, and therapy resistance.
A UD, Shukla PK.
europepmc   +2 more sources

Knockdown of PATZ1 alleviates chronic heart failure through the USP22/HIF-1α axis [PDF]

Scientific Reports
The pathogenesis of chronic heart failure (CHF) is complex and not fully understood. HIF-1α plays a paradoxical role in CHF, and its stability is regulated by the deubiquitinating enzyme USP22.
Yuntao Luo, Fang Zhou, Qingyang Chen, Huzhi Cai, Kunpeng Yao, Xu Deng   +5 more
doaj   +2 more sources

Silencing of USP22 promotes FGF11 degradation to attenuates renal fibrosis in diabetic kidney disease [PDF]

Renal Failure
Objectives: Diabetic kidney disease (DKD) is a major cause of end-stage renal disease that is characterized by renal fibrosis. Fibroblast growth factor 11 (FGF11) is reported to be involved in mesangial cell fibrosis; however, its mechanism is not fully ...
Zhigang Wang, Chao Liu, Jing Lv, Jiping Sun, Xiaoyang Yu, Huixian Li   +5 more
doaj   +2 more sources

Biochemical and Comparative Proteomic Analyses Delineate the Anti-Ovarian Carcinogenic Roles of Modified Calycosin. [PDF]

Food Sci Nutr
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Yang F, Li X, Gao H, Yao P, Qin X, Lin X, Lai KP, Tian J, Chen J.   +8 more
europepmc   +2 more sources

USP22 knockdown attenuates P. gingivalis-induced EndoMT and CNS inflammation: a link between periodontitis and neuroinflammation [PDF]

Frontiers in Neuroscience
ObjectiveChronic periodontitis is a significant risk factor for systemic disorders. However, the precise mechanism through which the “oral-brain axis” mediates its impact on the central nervous system remains unclear.
Hui Wang, Mengxian Wang, Jiaming Shen, Hao Zhang, Chengwei Duan   +4 more
doaj   +2 more sources