Results 51 to 60 of about 2,520 (194)

Clinicopathological and Prognostic Value of USP22 Expression in Gastric Cancer: A Systematic Review and Meta-Analysis and Database Validation

Frontiers in Surgery, 2022
BackgroundIt has been reported that there is a correlation between the level of ubiquitin-specific protease 22 (USP22) and the clinicopathological parameters and prognosis of gastric cancer (GC) patients, but the conclusions are inconsistent.
Yuhang Wang, Yuhang Wang, Zirui Jia, Zirui Jia, Jiacheng Gao, Jiacheng Gao, Tingting Zhou, Xiangwen Zhang, Guo Zu   +8 more
doaj   +1 more source

Correlation of USP22 and SOX2 in SACC.

, 2014
(a-d) SACC from serial sections of two patients (specimen 1 and 2) were subjected to immunohistochemical staining of USP22 (a and c) and SOX2 (b and d). (a) intermediate expression of USP22, (c) strong expression of USP22, (b) strong expression of SOX2, (
Qing Zhou (52712), Yuan Yao (31223), Wei Dai (95957), Chang-fu Sun (457057)   +3 more
core   +1 more source

Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer

Cell Communication and Signaling, 2019
Background Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor differentiation, cancer stemness, and enhanced malignancy of non-small cell lung cancer (NSCLC).
Keqiang Zhang, Lu Yang, Jinhui Wang, Ting Sun, Yuming Guo, Rebecca Nelson, Tommy R. Tong, Rajendra Pangeni, Ravi Salgia, Dan J. Raz   +9 more
doaj   +1 more source

Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis

Cell Death Discovery, 2022
Overproduction of reactive oxygen species (ROS) and aberrant lipid metabolism are established hallmarks of cancer; however, the role of ROS in lipid synthesis during tumorigenesis is almost unknown.
Zelong Han, Ming Liu, Yuxin Xie, Kunlin Zeng, Ziling Zhan, Yanwen Chen, Li Wang, Xiaoxia Chen, Yaxin Luo, Yu Zeng, Hongchao Zhan, Yingzhuo Lin, Keqin Zhang, Xiaoxia Zhu, Side Liu, Xiaobei Luo, Aidong Zhou   +16 more
doaj   +1 more source

USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization

Oncology Letters, 2021
Yes-associated protein (YAP) is a conserved transcriptional coactivator that plays key roles in controlling organ size, tumorigenesis and drug resistance. Emerging evidence shows that YAP is overexpressed and associated with resistance to BRAF inhibitor treatment in melanoma.
Wei, Ying, Jiang, Ziyun, Lu, Jianfeng
openaire   +3 more sources

USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.

, 2021
The Ubiquitin-Specific Protease 22 (USP22) is a deubiquitinating subunit of the mammalian SAGA transcriptional co-activating complex. USP22 was identified as a member of the so-called "death-from-cancer" signature predicting therapy failure in cancer ...
Johnsen, Steven A., Bedi, Upasana, Fritzsche, Sonja, Johnsen, Steven, Prokakis, Evangelos, Kazerouni, Zahra B., Prokakis, Dr. rer. nat. Evangelos, Wegwitz, Florian, Kosinsky, Robyn Laura, Dyas, Anna, Kosinsky, Robyn L., Grün, Regina   +11 more
core   +1 more source

P38 Mitogen-Activated Protein Kinase Protects Against Retinoblastoma Through Regulating USP22/SIRT1/SOST Axis

Frontiers in Oncology, 2022
Retinoblastoma (RB) is the most common intraocular malignancy in children. It has been previously reported that p38 MAPK is related to the pathogenesis of RB. Here we aim at investigating how p38 MAPK affected RB progression through mediating USP22/SIRT1/
Xiaoming Huang, Xiaoming Huang, Jianfeng Wan, Fei Liu, Yang Liu, Lina Wang, Sidi Zhao, Tong Wu, Tong Wu, Fengyuan Sun, Fengyuan Sun   +10 more
doaj   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Abstract 4451: Elevated USP22 is a potential therapeutic target for human non-small cell lung cancer

, 2017
Elevated ubiquitin-specific protease 22 (USP22) is associated with enhanced malignancy, therapeutic resistance, and poor prognosis of various human cancers.
Ravi Salgia, Dan Raz, Keqiang Zhang, Xinwei Yun, Nardi Isaac, Rebecca Nelson, Tommy R Tong   +6 more
core   +1 more source

Hypoxia‐preconditioned adipose‐derived mesenchymal stem cells‐derived exosomes transferring H19 obstruct neutrophil extracellular traps formation via HOXA5‐mediated inactivation of TLR4/NF‐κB/NLRP3 inflammatory signaling

Journal of Diabetes Investigation, EarlyView.
In this study, we uncovered that Hypo‐Exo transferring H19 promoted diabetic wound healing by repressing NETs formation via the miR‐130a/b‐3p/HOXA5 pathway to inactivate the TLR4/NF‐κB/NLRP3 inflammatory signaling. ABSTRACT Background Hypoxia‐stimulated adipose‐derived mesenchymal stem cells (ADSCs)‐derived exosomes (Hypo‐Exo) have a positive impact on
Li Qian, Xianxi Meng, Bairong Fang, Li Pi   +3 more
wiley   +1 more source